Comparison of actual and random-positioning-model distributions of peptide scavenging and T cell-presented sites in antigenic proteins

Markus Salomon, Sharlene Adams, Animesh Pardanani, Stephen Vazquez, Robert E. Humphreys, Robert A. Lew

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

In a peptide with a T cell-presented epitope (T site), a folded structure with a hydrophobic surface, 'the scavenger (S) site', may regulate transfer to major histocompatibility complex class II molecules. Three procedures which were proposed to identify T sites selected for amphipathic helical patterns but not T sites. In testing whether S sites lay in or near T sites, we found their linkage was not greater than that generated by a model in which segments of equal length and number to the S and T sites for each protein were distributed at random. This study establishes criteria for evaluation of schemes to predict functional motifs in antigenic proteins.

Original languageEnglish (US)
Pages (from-to)1067-1073
Number of pages7
JournalVaccine
Volume11
Issue number10
DOIs
StatePublished - 1993

Keywords

  • Peptide
  • T cell-presented site
  • overlap
  • scavenger site

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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