Comparison of actual and random-positioning-model distributions of peptide scavenging and T cell-presented sites in antigenic proteins

Markus Salomon, Sharlene Adams, Animesh D Pardanani, Stephen Vazquez, Robert E. Humphreys, Robert A. Lew

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In a peptide with a T cell-presented epitope (T site), a folded structure with a hydrophobic surface, 'the scavenger (S) site', may regulate transfer to major histocompatibility complex class II molecules. Three procedures which were proposed to identify T sites selected for amphipathic helical patterns but not T sites. In testing whether S sites lay in or near T sites, we found their linkage was not greater than that generated by a model in which segments of equal length and number to the S and T sites for each protein were distributed at random. This study establishes criteria for evaluation of schemes to predict functional motifs in antigenic proteins.

Original languageEnglish (US)
Pages (from-to)1067-1073
Number of pages7
JournalVaccine
Volume11
Issue number10
DOIs
StatePublished - 1993
Externally publishedYes

Fingerprint

Peptide T
T-lymphocytes
peptides
T-Lymphocytes
T-Lymphocyte Epitopes
major histocompatibility complex
Major Histocompatibility Complex
epitopes
linkage (genetics)
Proteins
proteins
Peptides
testing

Keywords

  • overlap
  • Peptide
  • scavenger site
  • T cell-presented site

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

Cite this

Comparison of actual and random-positioning-model distributions of peptide scavenging and T cell-presented sites in antigenic proteins. / Salomon, Markus; Adams, Sharlene; Pardanani, Animesh D; Vazquez, Stephen; Humphreys, Robert E.; Lew, Robert A.

In: Vaccine, Vol. 11, No. 10, 1993, p. 1067-1073.

Research output: Contribution to journalArticle

Salomon, Markus ; Adams, Sharlene ; Pardanani, Animesh D ; Vazquez, Stephen ; Humphreys, Robert E. ; Lew, Robert A. / Comparison of actual and random-positioning-model distributions of peptide scavenging and T cell-presented sites in antigenic proteins. In: Vaccine. 1993 ; Vol. 11, No. 10. pp. 1067-1073.
@article{e01daf54bec14838b37feecc662e6651,
title = "Comparison of actual and random-positioning-model distributions of peptide scavenging and T cell-presented sites in antigenic proteins",
abstract = "In a peptide with a T cell-presented epitope (T site), a folded structure with a hydrophobic surface, 'the scavenger (S) site', may regulate transfer to major histocompatibility complex class II molecules. Three procedures which were proposed to identify T sites selected for amphipathic helical patterns but not T sites. In testing whether S sites lay in or near T sites, we found their linkage was not greater than that generated by a model in which segments of equal length and number to the S and T sites for each protein were distributed at random. This study establishes criteria for evaluation of schemes to predict functional motifs in antigenic proteins.",
keywords = "overlap, Peptide, scavenger site, T cell-presented site",
author = "Markus Salomon and Sharlene Adams and Pardanani, {Animesh D} and Stephen Vazquez and Humphreys, {Robert E.} and Lew, {Robert A.}",
year = "1993",
doi = "10.1016/0264-410X(93)90135-K",
language = "English (US)",
volume = "11",
pages = "1067--1073",
journal = "Vaccine",
issn = "0264-410X",
publisher = "Elsevier BV",
number = "10",

}

TY - JOUR

T1 - Comparison of actual and random-positioning-model distributions of peptide scavenging and T cell-presented sites in antigenic proteins

AU - Salomon, Markus

AU - Adams, Sharlene

AU - Pardanani, Animesh D

AU - Vazquez, Stephen

AU - Humphreys, Robert E.

AU - Lew, Robert A.

PY - 1993

Y1 - 1993

N2 - In a peptide with a T cell-presented epitope (T site), a folded structure with a hydrophobic surface, 'the scavenger (S) site', may regulate transfer to major histocompatibility complex class II molecules. Three procedures which were proposed to identify T sites selected for amphipathic helical patterns but not T sites. In testing whether S sites lay in or near T sites, we found their linkage was not greater than that generated by a model in which segments of equal length and number to the S and T sites for each protein were distributed at random. This study establishes criteria for evaluation of schemes to predict functional motifs in antigenic proteins.

AB - In a peptide with a T cell-presented epitope (T site), a folded structure with a hydrophobic surface, 'the scavenger (S) site', may regulate transfer to major histocompatibility complex class II molecules. Three procedures which were proposed to identify T sites selected for amphipathic helical patterns but not T sites. In testing whether S sites lay in or near T sites, we found their linkage was not greater than that generated by a model in which segments of equal length and number to the S and T sites for each protein were distributed at random. This study establishes criteria for evaluation of schemes to predict functional motifs in antigenic proteins.

KW - overlap

KW - Peptide

KW - scavenger site

KW - T cell-presented site

UR - http://www.scopus.com/inward/record.url?scp=0027514970&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027514970&partnerID=8YFLogxK

U2 - 10.1016/0264-410X(93)90135-K

DO - 10.1016/0264-410X(93)90135-K

M3 - Article

VL - 11

SP - 1067

EP - 1073

JO - Vaccine

JF - Vaccine

SN - 0264-410X

IS - 10

ER -