Comparison of accelerated T1-weighted whole-brain structural-imaging protocols

Pavel Falkovskiy, Daniel Brenner, Thorsten Feiweier, Stephan Kannengiesser, Bénédicte Maréchal, Tobias Kober, Alexis Roche, Kaely Thostenson, Reto Meuli, Denise Reyes, Tony Stoecker, Matthew A Bernstein, Jean Philippe Thiran, Gunnar Krueger

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6 Citations (Scopus)

Abstract

Imaging in neuroscience, clinical research and pharmaceutical trials often employs the 3D magnetisation-prepared rapid gradient-echo (MPRAGE) sequence to obtain structural T1-weighted images with high spatial resolution of the human brain. Typical research and clinical routine MPRAGE protocols with ~. 1. mm isotropic resolution require data acquisition time in the range of 5-10. min and often use only moderate two-fold acceleration factor for parallel imaging. Recent advances in MRI hardware and acquisition methodology promise improved leverage of the MR signal and more benign artefact properties in particular when employing increased acceleration factors in clinical routine and research. In this study, we examined four variants of a four-fold-accelerated MPRAGE protocol (2D-GRAPPA, CAIPIRINHA, CAIPIRINHA elliptical, and segmented MPRAGE) and compared clinical readings, basic image quality metrics (SNR, CNR), and automated brain tissue segmentation for morphological assessments of brain structures. The results were benchmarked against a widely-used two-fold-accelerated 3T ADNI MPRAGE protocol that served as reference in this study.22 healthy subjects (age. = 20-44. yrs.) were imaged with all MPRAGE variants in a single session. An experienced reader rated all images of clinically useful image quality. CAIPIRINHA MPRAGE scans were perceived on average to be of identical value for reading as the reference ADNI-2 protocol. SNR and CNR measurements exhibited the theoretically expected performance at the four-fold acceleration. The results of this study demonstrate that the four-fold accelerated protocols introduce systematic biases in the segmentation results of some brain structures compared to the reference ADNI-2 protocol. Furthermore, results suggest that the increased noise levels in the accelerated protocols play an important role in introducing these biases, at least under the present study conditions.

Original languageEnglish (US)
Article number12506
Pages (from-to)157-167
Number of pages11
JournalNeuroImage
Volume124
DOIs
StatePublished - Jan 1 2016

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Neuroimaging
Brain
Reading
Neurosciences
Research
Artifacts
Noise
Healthy Volunteers

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

Falkovskiy, P., Brenner, D., Feiweier, T., Kannengiesser, S., Maréchal, B., Kober, T., ... Krueger, G. (2016). Comparison of accelerated T1-weighted whole-brain structural-imaging protocols. NeuroImage, 124, 157-167. [12506]. https://doi.org/10.1016/j.neuroimage.2015.08.026

Comparison of accelerated T1-weighted whole-brain structural-imaging protocols. / Falkovskiy, Pavel; Brenner, Daniel; Feiweier, Thorsten; Kannengiesser, Stephan; Maréchal, Bénédicte; Kober, Tobias; Roche, Alexis; Thostenson, Kaely; Meuli, Reto; Reyes, Denise; Stoecker, Tony; Bernstein, Matthew A; Thiran, Jean Philippe; Krueger, Gunnar.

In: NeuroImage, Vol. 124, 12506, 01.01.2016, p. 157-167.

Research output: Contribution to journalArticle

Falkovskiy, P, Brenner, D, Feiweier, T, Kannengiesser, S, Maréchal, B, Kober, T, Roche, A, Thostenson, K, Meuli, R, Reyes, D, Stoecker, T, Bernstein, MA, Thiran, JP & Krueger, G 2016, 'Comparison of accelerated T1-weighted whole-brain structural-imaging protocols', NeuroImage, vol. 124, 12506, pp. 157-167. https://doi.org/10.1016/j.neuroimage.2015.08.026
Falkovskiy P, Brenner D, Feiweier T, Kannengiesser S, Maréchal B, Kober T et al. Comparison of accelerated T1-weighted whole-brain structural-imaging protocols. NeuroImage. 2016 Jan 1;124:157-167. 12506. https://doi.org/10.1016/j.neuroimage.2015.08.026
Falkovskiy, Pavel ; Brenner, Daniel ; Feiweier, Thorsten ; Kannengiesser, Stephan ; Maréchal, Bénédicte ; Kober, Tobias ; Roche, Alexis ; Thostenson, Kaely ; Meuli, Reto ; Reyes, Denise ; Stoecker, Tony ; Bernstein, Matthew A ; Thiran, Jean Philippe ; Krueger, Gunnar. / Comparison of accelerated T1-weighted whole-brain structural-imaging protocols. In: NeuroImage. 2016 ; Vol. 124. pp. 157-167.
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