Comparison of a gel versus solution-based vehicle for the delivery of acetylcholine in QSART

David M. Sletten; Kurt Kimpinski; Stephen D. Weigand; Phillip A. Low

doi:10.1016/j.autneu.2010.05.005

Comparison of a gel versus solution-based vehicle for the delivery of acetylcholine in QSART

David M. Sletten, Kurt Kimpinski, Stephen D. Weigand, Phillip A. Low

Neurology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Quantitative Sudomotor Axon Reflex Testing is a useful measure of post ganglionic sudomotor function. The test is based on the iontophoresis of an acetylcholine solution which induces a local sweat response. We have previously described a gel-based vehicle that may provide another option for the iontophoresis of acetylcholine. It was our objective to compare the influence of the vehicle (gel versus solution) on sudomotor recordings and perceived discomfort. Results show gel-based vehicles are very similar to solution-based vehicles during Quantitative Sudomotor Axon Reflex Testing.

Original language	English (US)
Pages (from-to)	123-126
Number of pages	4
Journal	Autonomic Neuroscience: Basic and Clinical
Volume	158
Issue number	1-2
DOIs	https://doi.org/10.1016/j.autneu.2010.05.005
State	Published - Dec 8 2010

Keywords

Acetylcholine
Gel
QSART
Solution
Sudomotor
Vehicle

ASJC Scopus subject areas

Endocrine and Autonomic Systems
Clinical Neurology
Cellular and Molecular Neuroscience

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10.1016/j.autneu.2010.05.005

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title = "Comparison of a gel versus solution-based vehicle for the delivery of acetylcholine in QSART",

abstract = "Quantitative Sudomotor Axon Reflex Testing is a useful measure of post ganglionic sudomotor function. The test is based on the iontophoresis of an acetylcholine solution which induces a local sweat response. We have previously described a gel-based vehicle that may provide another option for the iontophoresis of acetylcholine. It was our objective to compare the influence of the vehicle (gel versus solution) on sudomotor recordings and perceived discomfort. Results show gel-based vehicles are very similar to solution-based vehicles during Quantitative Sudomotor Axon Reflex Testing.",

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author = "Sletten, {David M.} and Kurt Kimpinski and Weigand, {Stephen D.} and Low, {Phillip A.}",

note = "Funding Information: We would like to thank Tonette Gehrking and Jade Gehrking for their technical assistance. This work was supported by NIH grants ( NS3 2352 , NS4 4233 , NS4 3364 , and UL1 RR24150 ) and Mayo Clinic . The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Neurological Disorders and Stroke or the National Institutes of Health.",

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AU - Weigand, Stephen D.

AU - Low, Phillip A.

N1 - Funding Information: We would like to thank Tonette Gehrking and Jade Gehrking for their technical assistance. This work was supported by NIH grants ( NS3 2352 , NS4 4233 , NS4 3364 , and UL1 RR24150 ) and Mayo Clinic . The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Neurological Disorders and Stroke or the National Institutes of Health.

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N2 - Quantitative Sudomotor Axon Reflex Testing is a useful measure of post ganglionic sudomotor function. The test is based on the iontophoresis of an acetylcholine solution which induces a local sweat response. We have previously described a gel-based vehicle that may provide another option for the iontophoresis of acetylcholine. It was our objective to compare the influence of the vehicle (gel versus solution) on sudomotor recordings and perceived discomfort. Results show gel-based vehicles are very similar to solution-based vehicles during Quantitative Sudomotor Axon Reflex Testing.

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Comparison of a gel versus solution-based vehicle for the delivery of acetylcholine in QSART

Abstract

Keywords

ASJC Scopus subject areas

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