Comparison of 20x2 Gy and 12x3 Gy for whole-brain irradiation of multiple brain metastases from malignant melanoma

Dirk Rades, Lena Sehmisch, Amira Bajrovic, Stefan Janssen, Steven E. Schild

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Background/Aim: Most patients with multiple brain metastases from melanoma receive whole-brain irradiation. In a previous study, doses >30 Gy resulted in better outcomes than 10x3 Gy. However, the optimal dose-fractionation regimen has not yet been defined. This study compared 20x2 Gy over four weeks, which was used in the previous study, to 12x3 Gy over two-and-a-half weeks. Patients and Methods: Eleven patients treated with 20x2 Gy for multiple brain metastases were compared to 12 patients treated with 12x3 Gy. Results: Intracerebral control rates at 6 and 12 months were 17% and 0% after 20x2 Gy vs. 42% and 11% after 12x3 Gy (p=0.28). Survival rates at 6 and 12 months were 36% and 9% after 20x2 Gy vs. 50% and 25% after 12x3 Gy (p=0.75). Conclusion: The less time-consuming regimen 12x3 Gy appeared not inferior to 20x2 Gy and a reasonable treatment option, particularly for patients with a limited life expectancy.

Original languageEnglish (US)
Pages (from-to)917-919
Number of pages3
JournalIn Vivo
Volume30
Issue number6
DOIs
StatePublished - Nov 1 2016

Keywords

  • Dose-fractionation regimens
  • Intracerebral control
  • Melanoma
  • Multiple brain metastases
  • Survival
  • Whole-brain irradiation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

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