Comparison of 2-D Shear Wave Elastography and Transient Elastography for Assessing Liver Fibrosis in Chronic Hepatitis B

Jie Zeng, Jian Zheng, Zeping Huang, Shigao D Chen, Jing Liu, Tao Wu, Rongqin Zheng, Mingde Lu

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

This study compared 2-D shear wave elastography (SWE) and transient elastography (TE) for liver fibrosis staging in patients with chronic hepatitis B (CHB) infection using liver biopsy as the reference standard. Patients with CHB infection who underwent liver biopsy were consecutively included. After exclusions, 257 patients were analyzed. Two-dimensional SWE resulted in a significantly higher rate of reliable measurements (98.1%, 252/257) than TE (93.0%, 239/257) (p = 0.011). Liver stiffness measurements of the two examinations exhibited a strong correlation (r = 0.835, p < 0.001). In patients given a confirmed histologic diagnosis, Spearman's rank coefficients were 0.520 in stage F0 (p < 0.001), 0.684 in stage F1 (p < 0.001), 0.777 in stage F2 (p < 0.001), 0.672 in stage F3 (p < 0.001) and 0.755 in stage F4 (p < 0.001). There were no significant differences between the areas under the receiver operating characteristic (ROC) curves of 2-D SWE and TE for liver fibrosis staging (all p values > 0.05). Two-dimensional SWE had diagnostic accuracy comparable to that of TE for liver fibrosis staging. The measurements that the two techniques provide are not interchangeable.

Original languageEnglish (US)
Pages (from-to)1563-1570
Number of pages8
JournalUltrasound in Medicine and Biology
Volume43
Issue number8
DOIs
StatePublished - Aug 1 2017

Fingerprint

hepatitis
Elasticity Imaging Techniques
fibrosis
Chronic Hepatitis B
liver
Liver Cirrhosis
S waves
infectious diseases
Liver
Biopsy
exclusion
Infection
stiffness
examination

Keywords

  • 2-D shear wave elastography
  • Hepatitis B
  • Liver fibrosis
  • Liver stiffness
  • Transient elastography

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Biophysics
  • Radiology Nuclear Medicine and imaging

Cite this

Comparison of 2-D Shear Wave Elastography and Transient Elastography for Assessing Liver Fibrosis in Chronic Hepatitis B. / Zeng, Jie; Zheng, Jian; Huang, Zeping; Chen, Shigao D; Liu, Jing; Wu, Tao; Zheng, Rongqin; Lu, Mingde.

In: Ultrasound in Medicine and Biology, Vol. 43, No. 8, 01.08.2017, p. 1563-1570.

Research output: Contribution to journalArticle

Zeng, Jie ; Zheng, Jian ; Huang, Zeping ; Chen, Shigao D ; Liu, Jing ; Wu, Tao ; Zheng, Rongqin ; Lu, Mingde. / Comparison of 2-D Shear Wave Elastography and Transient Elastography for Assessing Liver Fibrosis in Chronic Hepatitis B. In: Ultrasound in Medicine and Biology. 2017 ; Vol. 43, No. 8. pp. 1563-1570.
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