Comparing the incidence of ventricular arrhythmias during epicardial ablation in swine versus canine models

Guido Caluori, Adam Wojtaszczyk, Omar Yasin, Martin Pesl, Jiří Wolf, Silvie Belaskova, Michal Crha, Alan Sugrue, Vaibhav R. Vaidya, Niyada Naksuk, Christopher V. DeSimone, Ammar M. Killu, Deepak Padmanabhan, Samuel J Asirvatham, Zdeněk Stárek

Research output: Contribution to journalArticle

Abstract

Background: Choosing the appropriate animal model for development of novel technologies requires an understanding of anatomy and physiology of these different models. There are little data about the characteristics of different animal models for the study of technologies used for epicardial ablation. We aimed to compare the incidence of ventricular arrhythmias during epicardial radiofrequency ablation between swine and canine models using novel epicardial ablation catheters. Methods: We conducted a retrospective study using data obtained from epicardial ablation experiments performed on swine (Sus Scrofa) and canine (Canis familiaris) models. We compared the incidence of ventricular arrhythmias during ablation between swine and canine using multivariate regression analysis. Six swine and six canine animals underwent successful epicardial radiofrequency ablation. A total of 103 ablation applications were recorded. Results: Ventricular arrhythmias requiring cardioversion occurred in 13.11% of radiofrequency ablation applications in swine and 9.75% in canine (relative risk: 117.6%, 95% confidence interval [CI]: 83.97-164.69, animal-based odds ratio [OR]:.55, 95% CI:.23-61.33; P =.184). When adjusting for application position, duration of ablation and power, the odds of developing potentially lethal ventricular arrhythmia in swine increased significantly compared to canine (OR: 3.60, 95% CI: 1.35-9.55; P =.010). Conclusions: The swine myocardium is more susceptible to developing ventricular arrhythmias compared to canine model during epicardial ablation. This issue should be carefully considered in future studies.

Original languageEnglish (US)
JournalPACE - Pacing and Clinical Electrophysiology
DOIs
StatePublished - Jan 1 2019

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Canidae
Cardiac Arrhythmias
Swine
Incidence
Confidence Intervals
Animal Models
Odds Ratio
Technology
Sus scrofa
Electric Countershock
Catheter Ablation
Anatomy
Myocardium
Multivariate Analysis
Retrospective Studies
Regression Analysis
Dogs

Keywords

  • animal model electrophysiology
  • cardiovascular devices
  • preclinical cardiology
  • radiofrequency catheter ablation
  • ventricular arrhythmia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Comparing the incidence of ventricular arrhythmias during epicardial ablation in swine versus canine models. / Caluori, Guido; Wojtaszczyk, Adam; Yasin, Omar; Pesl, Martin; Wolf, Jiří; Belaskova, Silvie; Crha, Michal; Sugrue, Alan; Vaidya, Vaibhav R.; Naksuk, Niyada; DeSimone, Christopher V.; Killu, Ammar M.; Padmanabhan, Deepak; Asirvatham, Samuel J; Stárek, Zdeněk.

In: PACE - Pacing and Clinical Electrophysiology, 01.01.2019.

Research output: Contribution to journalArticle

Caluori, G, Wojtaszczyk, A, Yasin, O, Pesl, M, Wolf, J, Belaskova, S, Crha, M, Sugrue, A, Vaidya, VR, Naksuk, N, DeSimone, CV, Killu, AM, Padmanabhan, D, Asirvatham, SJ & Stárek, Z 2019, 'Comparing the incidence of ventricular arrhythmias during epicardial ablation in swine versus canine models', PACE - Pacing and Clinical Electrophysiology. https://doi.org/10.1111/pace.13698
Caluori, Guido ; Wojtaszczyk, Adam ; Yasin, Omar ; Pesl, Martin ; Wolf, Jiří ; Belaskova, Silvie ; Crha, Michal ; Sugrue, Alan ; Vaidya, Vaibhav R. ; Naksuk, Niyada ; DeSimone, Christopher V. ; Killu, Ammar M. ; Padmanabhan, Deepak ; Asirvatham, Samuel J ; Stárek, Zdeněk. / Comparing the incidence of ventricular arrhythmias during epicardial ablation in swine versus canine models. In: PACE - Pacing and Clinical Electrophysiology. 2019.
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abstract = "Background: Choosing the appropriate animal model for development of novel technologies requires an understanding of anatomy and physiology of these different models. There are little data about the characteristics of different animal models for the study of technologies used for epicardial ablation. We aimed to compare the incidence of ventricular arrhythmias during epicardial radiofrequency ablation between swine and canine models using novel epicardial ablation catheters. Methods: We conducted a retrospective study using data obtained from epicardial ablation experiments performed on swine (Sus Scrofa) and canine (Canis familiaris) models. We compared the incidence of ventricular arrhythmias during ablation between swine and canine using multivariate regression analysis. Six swine and six canine animals underwent successful epicardial radiofrequency ablation. A total of 103 ablation applications were recorded. Results: Ventricular arrhythmias requiring cardioversion occurred in 13.11{\%} of radiofrequency ablation applications in swine and 9.75{\%} in canine (relative risk: 117.6{\%}, 95{\%} confidence interval [CI]: 83.97-164.69, animal-based odds ratio [OR]:.55, 95{\%} CI:.23-61.33; P =.184). When adjusting for application position, duration of ablation and power, the odds of developing potentially lethal ventricular arrhythmia in swine increased significantly compared to canine (OR: 3.60, 95{\%} CI: 1.35-9.55; P =.010). Conclusions: The swine myocardium is more susceptible to developing ventricular arrhythmias compared to canine model during epicardial ablation. This issue should be carefully considered in future studies.",
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author = "Guido Caluori and Adam Wojtaszczyk and Omar Yasin and Martin Pesl and Jiř{\'i} Wolf and Silvie Belaskova and Michal Crha and Alan Sugrue and Vaidya, {Vaibhav R.} and Niyada Naksuk and DeSimone, {Christopher V.} and Killu, {Ammar M.} and Deepak Padmanabhan and Asirvatham, {Samuel J} and Zdeněk St{\'a}rek",
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T1 - Comparing the incidence of ventricular arrhythmias during epicardial ablation in swine versus canine models

AU - Caluori, Guido

AU - Wojtaszczyk, Adam

AU - Yasin, Omar

AU - Pesl, Martin

AU - Wolf, Jiří

AU - Belaskova, Silvie

AU - Crha, Michal

AU - Sugrue, Alan

AU - Vaidya, Vaibhav R.

AU - Naksuk, Niyada

AU - DeSimone, Christopher V.

AU - Killu, Ammar M.

AU - Padmanabhan, Deepak

AU - Asirvatham, Samuel J

AU - Stárek, Zdeněk

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Choosing the appropriate animal model for development of novel technologies requires an understanding of anatomy and physiology of these different models. There are little data about the characteristics of different animal models for the study of technologies used for epicardial ablation. We aimed to compare the incidence of ventricular arrhythmias during epicardial radiofrequency ablation between swine and canine models using novel epicardial ablation catheters. Methods: We conducted a retrospective study using data obtained from epicardial ablation experiments performed on swine (Sus Scrofa) and canine (Canis familiaris) models. We compared the incidence of ventricular arrhythmias during ablation between swine and canine using multivariate regression analysis. Six swine and six canine animals underwent successful epicardial radiofrequency ablation. A total of 103 ablation applications were recorded. Results: Ventricular arrhythmias requiring cardioversion occurred in 13.11% of radiofrequency ablation applications in swine and 9.75% in canine (relative risk: 117.6%, 95% confidence interval [CI]: 83.97-164.69, animal-based odds ratio [OR]:.55, 95% CI:.23-61.33; P =.184). When adjusting for application position, duration of ablation and power, the odds of developing potentially lethal ventricular arrhythmia in swine increased significantly compared to canine (OR: 3.60, 95% CI: 1.35-9.55; P =.010). Conclusions: The swine myocardium is more susceptible to developing ventricular arrhythmias compared to canine model during epicardial ablation. This issue should be carefully considered in future studies.

AB - Background: Choosing the appropriate animal model for development of novel technologies requires an understanding of anatomy and physiology of these different models. There are little data about the characteristics of different animal models for the study of technologies used for epicardial ablation. We aimed to compare the incidence of ventricular arrhythmias during epicardial radiofrequency ablation between swine and canine models using novel epicardial ablation catheters. Methods: We conducted a retrospective study using data obtained from epicardial ablation experiments performed on swine (Sus Scrofa) and canine (Canis familiaris) models. We compared the incidence of ventricular arrhythmias during ablation between swine and canine using multivariate regression analysis. Six swine and six canine animals underwent successful epicardial radiofrequency ablation. A total of 103 ablation applications were recorded. Results: Ventricular arrhythmias requiring cardioversion occurred in 13.11% of radiofrequency ablation applications in swine and 9.75% in canine (relative risk: 117.6%, 95% confidence interval [CI]: 83.97-164.69, animal-based odds ratio [OR]:.55, 95% CI:.23-61.33; P =.184). When adjusting for application position, duration of ablation and power, the odds of developing potentially lethal ventricular arrhythmia in swine increased significantly compared to canine (OR: 3.60, 95% CI: 1.35-9.55; P =.010). Conclusions: The swine myocardium is more susceptible to developing ventricular arrhythmias compared to canine model during epicardial ablation. This issue should be carefully considered in future studies.

KW - animal model electrophysiology

KW - cardiovascular devices

KW - preclinical cardiology

KW - radiofrequency catheter ablation

KW - ventricular arrhythmia

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