Comparing Intensity-Modulated Proton Therapy With Intensity-Modulated Photon Therapy for Oropharyngeal Cancer: The Journey From Clinical Trial Concept to Activation

Steven J. Frank, Pierre Blanchard, J. Jack Lee, Erich M. Sturgis, Merrill S. Kies, Mitchell Machtay, Bhadrasain Vikram, Adam S. Garden, David I. Rosenthal, G. Brandon Gunn, C. David Fuller, Katherine Hutcheson, Stephen Lai, Paul M. Busse, Nancy Y. Lee, Alexander Lin, Robert L. Foote

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

Intensity-modulated proton therapy minimizes the incidental irradiation of normal tissues in patients with head and neck cancer relative to intensity-modulated photon (x-ray) therapy and has been associated with lesser treatment-related toxicity and improved quality of life. A phase II/III randomized trial sponsored by the US National Cancer Institute is currently underway to compare deintensification treatment strategies with intensity-modulated proton therapy vs intensity-modulated photon (x-ray) therapy for patients with advanced-stage oropharyngeal tumors. After significant input from numerous stakeholders, the phase III portion of the randomized trial was redesigned as a noninferiority trial with progression-free survival as the primary endpoint. The process by which that redesign took place is described here.

Original languageEnglish (US)
Pages (from-to)108-113
Number of pages6
JournalSeminars in Radiation Oncology
Volume28
Issue number2
DOIs
StatePublished - Apr 2018

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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    Frank, S. J., Blanchard, P., Lee, J. J., Sturgis, E. M., Kies, M. S., Machtay, M., Vikram, B., Garden, A. S., Rosenthal, D. I., Gunn, G. B., Fuller, C. D., Hutcheson, K., Lai, S., Busse, P. M., Lee, N. Y., Lin, A., & Foote, R. L. (2018). Comparing Intensity-Modulated Proton Therapy With Intensity-Modulated Photon Therapy for Oropharyngeal Cancer: The Journey From Clinical Trial Concept to Activation. Seminars in Radiation Oncology, 28(2), 108-113. https://doi.org/10.1016/j.semradonc.2017.12.002