Abstract
This study compared monophasic 100-μs pulses with high-frequency electroporation (HF-EP) bursts using an in vivo animal model. Myocardial damage was evaluated by histologic analysis. Compared with 10 monophasic pulses, 20 bursts of HF-EP at 100 and 150 kHz were associated with less damage. However, when the number of HF-EP bursts was increased to 60, myocardial damage was comparable to that of the monophasic group. HF-EP protocols were associated with attenuated collateral muscle contractions. This study shows that HF-EP is feasible and effective and that pulse frequency has a significant effect on extent of ablation.
Original language | English (US) |
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Pages (from-to) | 959-964 |
Number of pages | 6 |
Journal | JACC: Clinical Electrophysiology |
Volume | 7 |
Issue number | 8 |
DOIs | |
State | Published - Aug 2021 |
Keywords
- H-FIRE
- electroporation
- muscle contraction
- pulsed field ablation
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Physiology (medical)