Comparative systematic review and meta-analysis of compression modalities for the promotion of venous ulcer healing and reducing ulcer recurrence

Karen F. Mauck, Noor Asi, Tarig A. Elraiyah, Chaitanya Undavalli, Mohammed Nabhan, Osama Altayar, Mohamad Bassam Sonbol, Larry J. Prokop, Mohammad Hassan Murad

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Objective This was a systematic review of the literature to determine which compression method is superior in promoting ulcer healing and reducing recurrence in patients with lower extremity venous ulcer disease. Methods We conducted a comprehensive search of multiple databases for randomized and nonrandomized comparative studies from 1990 to December 2013. Results We identified 36 studies and two Cochrane systematic reviews. Many studies had moderate risk of bias. We found no overall difference between compression stockings vs compression bandages with respect to ulcer healing, time to ulcer healing, or ulcer recurrence outcomes. When we compared stockings vs short stretch bandages, stockings were superior with respect to ulcer healing. However, stockings compared with four-layer systems showed no difference in ulcer healing outcomes. When four-layer systems were compared with compression with less than four layers, there was also no significant difference in ulcer healing outcomes. Similarly, short stretch bandages were not superior to long stretch bandages with respect to ulcer healing, time to ulcer healing, or ulcer recurrence. One Cochrane review presented many additional comparisons and reported increased wound healing with compression compared with no compression, with multicomponent systems over single component systems, and compression systems with an elastic component over no elastic component. Another Cochrane review demonstrated a reduction in recurrence with compression in patients with healed ulcers. Conclusions At least moderate-quality evidence supports compression over no compression, multicomponent systems over single component systems, and systems with an elastic component over those without. We did not find significant differences with respect to ulcer healing outcomes for other comparisons. Low-quality evidence supports the effect of compression on ulcer recurrence.

Original languageEnglish (US)
Pages (from-to)71S-90S.e2
JournalJournal of vascular surgery
Volume60
Issue number2 SUPPL.
DOIs
StatePublished - Aug 2014

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine

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