TY - JOUR
T1 - Comparative study of different surgical procedures using sensory nerves or neurons for delaying atrophy of denervated skeletal muscle
AU - Wang, H.
AU - Gu, Y.
AU - Xu, J.
AU - Shen, L.
AU - Li, J.
PY - 2001
Y1 - 2001
N2 - To observe the effect of sensory components on muscle atrophy, 4 surgical procedures applying sensory nerves or neurons to the denervated muscle were conducted in a rat model: sensory nerve implantation (group B), sensory motor nerve crossover (group C), dorsal root ganglia implantation (group D), and implantation of preganglionically avulsed sensory nerve (group E). Rats with complete denervation served as controls (group A). The degree of muscle atrophy was evaluated after surgery by fibrillation potential amplitude, muscle wet weight, muscle fiber cross-sectional area, collagen content, and protein content. Compared with group A, the results in groups B, D, and E were superior 1 month after surgery and the results in groups B, C, and E were superior 3 months after surgery. Implantation of normal or preganglionically avulsed sensory nerve delayed atrophy. Dorsal root ganglia implantation only had a short-term trophic influence. In the animal model setting, sensory motor nerve crossover is effective only after it is maintained for at least 3 months.
AB - To observe the effect of sensory components on muscle atrophy, 4 surgical procedures applying sensory nerves or neurons to the denervated muscle were conducted in a rat model: sensory nerve implantation (group B), sensory motor nerve crossover (group C), dorsal root ganglia implantation (group D), and implantation of preganglionically avulsed sensory nerve (group E). Rats with complete denervation served as controls (group A). The degree of muscle atrophy was evaluated after surgery by fibrillation potential amplitude, muscle wet weight, muscle fiber cross-sectional area, collagen content, and protein content. Compared with group A, the results in groups B, D, and E were superior 1 month after surgery and the results in groups B, C, and E were superior 3 months after surgery. Implantation of normal or preganglionically avulsed sensory nerve delayed atrophy. Dorsal root ganglia implantation only had a short-term trophic influence. In the animal model setting, sensory motor nerve crossover is effective only after it is maintained for at least 3 months.
KW - Afferent neurons
KW - Brachial plexus
KW - Laboratory animals
KW - Muscular atrophy
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U2 - 10.1053/jhsu.2001.22522
DO - 10.1053/jhsu.2001.22522
M3 - Article
C2 - 11279580
AN - SCOPUS:0035083613
SN - 0363-5023
VL - 26
SP - 326
EP - 331
JO - Journal of Hand Surgery
JF - Journal of Hand Surgery
IS - 2
ER -