Comparative study of different surgical procedures using sensory nerves or neurons for delaying atrophy of denervated skeletal muscle

H. Wang, Y. Gu, J. Xu, L. Shen, J. Li

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

To observe the effect of sensory components on muscle atrophy, 4 surgical procedures applying sensory nerves or neurons to the denervated muscle were conducted in a rat model: sensory nerve implantation (group B), sensory motor nerve crossover (group C), dorsal root ganglia implantation (group D), and implantation of preganglionically avulsed sensory nerve (group E). Rats with complete denervation served as controls (group A). The degree of muscle atrophy was evaluated after surgery by fibrillation potential amplitude, muscle wet weight, muscle fiber cross-sectional area, collagen content, and protein content. Compared with group A, the results in groups B, D, and E were superior 1 month after surgery and the results in groups B, C, and E were superior 3 months after surgery. Implantation of normal or preganglionically avulsed sensory nerve delayed atrophy. Dorsal root ganglia implantation only had a short-term trophic influence. In the animal model setting, sensory motor nerve crossover is effective only after it is maintained for at least 3 months.

Original languageEnglish (US)
Pages (from-to)326-331
Number of pages6
JournalJournal of Hand Surgery
Volume26
Issue number2
DOIs
StatePublished - Jan 1 2001

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Keywords

  • Afferent neurons
  • Brachial plexus
  • Laboratory animals
  • Muscular atrophy

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

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