COMPARATIVE STUDIES OF FEMTOSECOND TO MICROSECOND LASER PULSES ON SELECTIVE PIGMENTED CELL INJURY IN SKIN

Shinichi Watanabe, R. Rox Anderson, Stuart Brorson, Gail Dalickas, James G. Fujimoto, Thomas J. Flotte

Research output: Contribution to journalArticlepeer-review

66 Scopus citations

Abstract

Abstract— —Threshold radiant exposures for grossly apparent immediate whitening and ultrastructural alterations of melanosomes in black guinea pig skin were determined for a series of red visible laser pulses ranging from 4 × 10−4 to 6.5 × 10−14 s. Threshold exposures for melanosomal injury were found to be independent of pulsewidth when the pulsewidths were below the estimated thermal relaxation time of melanosomes. Threshold radiant exposures for melanosomal injury were found to increase when the pulsewidths were approximately equal to or above the thermal relaxation time of melanosomes. At longer pulse durations, fracturing of melanosomes was not observed despite the longer exposures necessary for injury. Instead, perimelanosomal vacuoles were noted. These findings are consistent with the theory of selective photothermolysis and provide evidence for the thermal initiation of melanosomal disruption. 1991 American Society for Photobiology

Original languageEnglish (US)
Pages (from-to)757-762
Number of pages6
JournalPhotochemistry and Photobiology
Volume53
Issue number6
DOIs
StatePublished - Jun 1991

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry

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