Comparative sensitivity of cardiac troponin I and lactate dehydrogenase isoenzymes for diagnosing acute myocardial infarction

Allan S. Jaffe, Yvonne Landt, Curtis A. Parvin, Dana R. Abendschein, Edward M. Geltman, Jack H. Ladenson

Research output: Contribution to journalArticle

152 Scopus citations

Abstract

Criteria for the retrospective diagnosis of acute myocardial infarction rely heavily on increases in lactate dehydrogenase (LD) isoenzymes. However, increases of LD isoenzyme activities are not specific for myocardial injury. Recently, increased concentrations of cardiac troponin I (cTnI) have been shown to be highly specific for myocardial damage and to have sensitivity comparable with that of creatine kinase MB isoenzyme for detecting cardiac injury. Furthermore, increases of cTnI persist in plasma for at least several days. The present study was designed to determine the relative sensitivities of cTnI and LD isoenzymes over time for the diagnosis of infarction. The results indicate that cTnI values are at least as sensitive as LD isoenzymes: 90% of patients with myocardial infarction had above-normal concentrations of cTnI on the 4th day after admission to the coronary care unit. Criteria based on cTnI should improve the accuracy of retrospective diagnoses of acute myocardial infarction.

Original languageEnglish (US)
Pages (from-to)1770-1776
Number of pages7
JournalClinical chemistry
Volume42
Issue number11
DOIs
StatePublished - Jan 1 1996

Keywords

  • diagnostic sensitivity
  • heart disease
  • method comparisons

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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