Comparative morphine pharmacokinetics following sublingual, intramuscular, and oral administration in patients with cancer.

T. Davis, A. W. Miser, C. L. Loprinzi, J. S. Kaur, N. L. Burnham, A. M. Dose, M. M. Ames

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Previous literature reports have suggested that sublingually administered morphine sulfate results in an improved bioavailability of the drug when compared to orally administered morphine. To investigate this possibility further, we studied six cancer patients all of whom received 10 mg doses of morphine sulfate by intramuscular, oral and sublingual routes. Pharmacokinetic analyses failed to suggest an advantage of sublingual administration when compared with oral dosing. Bioavailability of morphine following intramuscular administration appeared superior to both oral and sublingual routes.

Original languageEnglish (US)
Pages (from-to)85-90
Number of pages6
JournalThe Hospice journal
Volume9
Issue number1
DOIs
StatePublished - 1993

ASJC Scopus subject areas

  • Health Policy
  • Public Health, Environmental and Occupational Health

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