Comparative mapping of a gorilla-derived alpha satellite DNA clone on great ape and human chromosomes

Antonio Baldini; Dorothy A. Miller; Viji Shridhar; Mariano Rocchi; Orlando J. Miller; David C. Ward

doi:10.1007/BF00357060

Comparative mapping of a gorilla-derived alpha satellite DNA clone on great ape and human chromosomes

Antonio Baldini, Dorothy A. Miller, Viji Shridhar, Mariano Rocchi, Orlando J. Miller, David C. Ward

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

We have isolated an alpha satellite DNA clone, pG3.9, from gorilla DNA. Fluorescence in situ hybridization on banded chromosomes under high stringency conditions revealed that pG3.9 identifies homologous sequences at the centromeric region of ten gorilla chromosomes, and, with few exceptions, also recognizes the homologous chromosomes in human. A pG3.9-like alphoid DNA is present on a larger number of orangutan chromosomes, but, in contrast, is present on only tow chromosomes in the chimpanzee. These results show that the chromosomal subsets of related alpha satellite DNA sequences may undergo different patterns of evolution.

Original language	English (US)
Pages (from-to)	109-114
Number of pages	6
Journal	Chromosoma
Volume	101
Issue number	2
DOIs	https://doi.org/10.1007/BF00357060
State	Published - Nov 1991

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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abstract = "We have isolated an alpha satellite DNA clone, pG3.9, from gorilla DNA. Fluorescence in situ hybridization on banded chromosomes under high stringency conditions revealed that pG3.9 identifies homologous sequences at the centromeric region of ten gorilla chromosomes, and, with few exceptions, also recognizes the homologous chromosomes in human. A pG3.9-like alphoid DNA is present on a larger number of orangutan chromosomes, but, in contrast, is present on only tow chromosomes in the chimpanzee. These results show that the chromosomal subsets of related alpha satellite DNA sequences may undergo different patterns of evolution.",

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AU - Rocchi, Mariano

AU - Miller, Orlando J.

AU - Ward, David C.

PY - 1991/11

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N2 - We have isolated an alpha satellite DNA clone, pG3.9, from gorilla DNA. Fluorescence in situ hybridization on banded chromosomes under high stringency conditions revealed that pG3.9 identifies homologous sequences at the centromeric region of ten gorilla chromosomes, and, with few exceptions, also recognizes the homologous chromosomes in human. A pG3.9-like alphoid DNA is present on a larger number of orangutan chromosomes, but, in contrast, is present on only tow chromosomes in the chimpanzee. These results show that the chromosomal subsets of related alpha satellite DNA sequences may undergo different patterns of evolution.

AB - We have isolated an alpha satellite DNA clone, pG3.9, from gorilla DNA. Fluorescence in situ hybridization on banded chromosomes under high stringency conditions revealed that pG3.9 identifies homologous sequences at the centromeric region of ten gorilla chromosomes, and, with few exceptions, also recognizes the homologous chromosomes in human. A pG3.9-like alphoid DNA is present on a larger number of orangutan chromosomes, but, in contrast, is present on only tow chromosomes in the chimpanzee. These results show that the chromosomal subsets of related alpha satellite DNA sequences may undergo different patterns of evolution.

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Comparative mapping of a gorilla-derived alpha satellite DNA clone on great ape and human chromosomes

Abstract

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