Comparative genomics of the eukaryotes

Gerald M. Rubin; Mark D. Yandell; Jennifer R. Wortman; George L. Gabor Miklos; Catherine R. Nelson; Iswar K. Hariharan; Mark E. Fortini; Peter W. Li; Rolf Apweiler; Wolfgang Fleischmann; J. Michael Cherry; Steven Henikoff; Marian P. Skupski; Sima Misra; Michael Ashburner; Ewan Birney; Mark S. Boguski; Thomas Brody; Peter Brokstein; Susan E. Celniker; Stephen A. Chervitz; David Coates; Anibal Cravchik; Andrei Gabrielian; Richard F. Galle; William M. Gelbart; Reed A. George; Lawrence S.B. Goldstein; Fangcheng Gong; Ping Guan; Nomi L. Harris; Bruce A. Hay; Roger A. Hoskins; Jiayin Li; Zhenya Li; Richard O. Hynes; S. J.M. Jones; Peter M. Kuehl; Bruno Lemaitre; J. Troy Littleton; Deborah K. Morrison; Chris Mungall; Patrick H. O'Farrell; Oxana K. Pickeral; Chris Shue; Leslie B. Vosshall; Jiong Zhang; Qi Zhao; Xiangqun H. Zheng; Fei Zhong; Wenyan Zhong; Richard Gibbs; J. Craig Venter; Mark D. Adams; Suzanna Lewis

doi:10.1126/science.287.5461.2204

Comparative genomics of the eukaryotes

Gerald M. Rubin, Mark D. Yandell, Jennifer R. Wortman, George L. Gabor Miklos, Catherine R. Nelson, Iswar K. Hariharan, Mark E. Fortini, Peter W. Li, Rolf Apweiler, Wolfgang Fleischmann, J. Michael Cherry, Steven Henikoff, Marian P. Skupski, Sima Misra, Michael Ashburner, Ewan Birney, Mark S. Boguski, Thomas Brody, Peter Brokstein, Susan E. CelnikerStephen A. Chervitz, David Coates, Anibal Cravchik, Andrei Gabrielian, Richard F. Galle, William M. Gelbart, Reed A. George, Lawrence S.B. Goldstein, Fangcheng Gong, Ping Guan, Nomi L. Harris, Bruce A. Hay, Roger A. Hoskins, Jiayin Li, Zhenya Li, Richard O. Hynes, S. J.M. Jones, Peter M. Kuehl, Bruno Lemaitre, J. Troy Littleton, Deborah K. Morrison, Chris Mungall, Patrick H. O'Farrell, Oxana K. Pickeral, Chris Shue, Leslie B. Vosshall, Jiong Zhang, Qi Zhao, Xiangqun H. Zheng, Fei Zhong, Wenyan Zhong, Richard Gibbs, J. Craig Venter, Mark D. Adams, Suzanna Lewis

Quantitative Health Sciences

Research output: Contribution to journal › Review article › peer-review

1294 Scopus citations

Abstract

A comparative analysis of the genomes of Drosophila melanogaster, Caenorhabditis elegans, and Saccharomyces cerevisiae - and the proteins they are predicted to encode - was undertaken in the context of cellular, developmental, and evolutionary processes. The nonredundant protein sets of fries and worms are similar in size and are only twice that of yeast, but different gene families are expanded in each genome, and the multidomain proteins and signaling pathways of the fly and worm are far more complex than those of yeast. The fly has orthologs to 177 of the 289 human disease genes examined and provides the foundation for rapid analysis of some of the basic processes involved in human disease.

Original language	English (US)
Pages (from-to)	2204-2215
Number of pages	12
Journal	Science
Volume	287
Issue number	5461
DOIs	https://doi.org/10.1126/science.287.5461.2204
State	Published - Mar 24 2000

ASJC Scopus subject areas

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Rubin, G. M., Yandell, M. D., Wortman, J. R., Gabor Miklos, G. L., Nelson, C. R., Hariharan, I. K., Fortini, M. E., Li, P. W., Apweiler, R., Fleischmann, W., Cherry, J. M., Henikoff, S., Skupski, M. P., Misra, S., Ashburner, M., Birney, E., Boguski, M. S., Brody, T., Brokstein, P., ... Lewis, S. (2000). Comparative genomics of the eukaryotes. Science, 287(5461), 2204-2215. https://doi.org/10.1126/science.287.5461.2204

Rubin, GM, Yandell, MD, Wortman, JR, Gabor Miklos, GL, Nelson, CR, Hariharan, IK, Fortini, ME, Li, PW, Apweiler, R, Fleischmann, W, Cherry, JM, Henikoff, S, Skupski, MP, Misra, S, Ashburner, M, Birney, E, Boguski, MS, Brody, T, Brokstein, P, Celniker, SE, Chervitz, SA, Coates, D, Cravchik, A, Gabrielian, A, Galle, RF, Gelbart, WM, George, RA, Goldstein, LSB, Gong, F, Guan, P, Harris, NL, Hay, BA, Hoskins, RA, Li, J, Li, Z, Hynes, RO, Jones, SJM, Kuehl, PM, Lemaitre, B, Littleton, JT, Morrison, DK, Mungall, C, O'Farrell, PH, Pickeral, OK, Shue, C, Vosshall, LB, Zhang, J, Zhao, Q, Zheng, XH, Zhong, F, Zhong, W, Gibbs, R, Venter, JC, Adams, MD & Lewis, S 2000, 'Comparative genomics of the eukaryotes', Science, vol. 287, no. 5461, pp. 2204-2215. https://doi.org/10.1126/science.287.5461.2204

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abstract = "A comparative analysis of the genomes of Drosophila melanogaster, Caenorhabditis elegans, and Saccharomyces cerevisiae - and the proteins they are predicted to encode - was undertaken in the context of cellular, developmental, and evolutionary processes. The nonredundant protein sets of fries and worms are similar in size and are only twice that of yeast, but different gene families are expanded in each genome, and the multidomain proteins and signaling pathways of the fly and worm are far more complex than those of yeast. The fly has orthologs to 177 of the 289 human disease genes examined and provides the foundation for rapid analysis of some of the basic processes involved in human disease.",

author = "Rubin, {Gerald M.} and Yandell, {Mark D.} and Wortman, {Jennifer R.} and {Gabor Miklos}, {George L.} and Nelson, {Catherine R.} and Hariharan, {Iswar K.} and Fortini, {Mark E.} and Li, {Peter W.} and Rolf Apweiler and Wolfgang Fleischmann and Cherry, {J. Michael} and Steven Henikoff and Skupski, {Marian P.} and Sima Misra and Michael Ashburner and Ewan Birney and Boguski, {Mark S.} and Thomas Brody and Peter Brokstein and Celniker, {Susan E.} and Chervitz, {Stephen A.} and David Coates and Anibal Cravchik and Andrei Gabrielian and Galle, {Richard F.} and Gelbart, {William M.} and George, {Reed A.} and Goldstein, {Lawrence S.B.} and Fangcheng Gong and Ping Guan and Harris, {Nomi L.} and Hay, {Bruce A.} and Hoskins, {Roger A.} and Jiayin Li and Zhenya Li and Hynes, {Richard O.} and Jones, {S. J.M.} and Kuehl, {Peter M.} and Bruno Lemaitre and Littleton, {J. Troy} and Morrison, {Deborah K.} and Chris Mungall and O'Farrell, {Patrick H.} and Pickeral, {Oxana K.} and Chris Shue and Vosshall, {Leslie B.} and Jiong Zhang and Qi Zhao and Zheng, {Xiangqun H.} and Fei Zhong and Wenyan Zhong and Richard Gibbs and Venter, {J. Craig} and Adams, {Mark D.} and Suzanna Lewis",

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T1 - Comparative genomics of the eukaryotes

AU - Rubin, Gerald M.

AU - Yandell, Mark D.

AU - Wortman, Jennifer R.

AU - Gabor Miklos, George L.

AU - Nelson, Catherine R.

AU - Hariharan, Iswar K.

AU - Fortini, Mark E.

AU - Li, Peter W.

AU - Apweiler, Rolf

AU - Fleischmann, Wolfgang

AU - Cherry, J. Michael

AU - Henikoff, Steven

AU - Skupski, Marian P.

AU - Misra, Sima

AU - Ashburner, Michael

AU - Birney, Ewan

AU - Boguski, Mark S.

AU - Brody, Thomas

AU - Brokstein, Peter

AU - Celniker, Susan E.

AU - Chervitz, Stephen A.

AU - Coates, David

AU - Cravchik, Anibal

AU - Gabrielian, Andrei

AU - Galle, Richard F.

AU - Gelbart, William M.

AU - George, Reed A.

AU - Goldstein, Lawrence S.B.

AU - Gong, Fangcheng

AU - Guan, Ping

AU - Harris, Nomi L.

AU - Hay, Bruce A.

AU - Hoskins, Roger A.

AU - Li, Jiayin

AU - Li, Zhenya

AU - Hynes, Richard O.

AU - Jones, S. J.M.

AU - Kuehl, Peter M.

AU - Lemaitre, Bruno

AU - Littleton, J. Troy

AU - Morrison, Deborah K.

AU - Mungall, Chris

AU - O'Farrell, Patrick H.

AU - Pickeral, Oxana K.

AU - Shue, Chris

AU - Vosshall, Leslie B.

AU - Zhang, Jiong

AU - Zhao, Qi

AU - Zheng, Xiangqun H.

AU - Zhong, Fei

AU - Zhong, Wenyan

AU - Gibbs, Richard

AU - Venter, J. Craig

AU - Adams, Mark D.

AU - Lewis, Suzanna

PY - 2000/3/24

Y1 - 2000/3/24

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AB - A comparative analysis of the genomes of Drosophila melanogaster, Caenorhabditis elegans, and Saccharomyces cerevisiae - and the proteins they are predicted to encode - was undertaken in the context of cellular, developmental, and evolutionary processes. The nonredundant protein sets of fries and worms are similar in size and are only twice that of yeast, but different gene families are expanded in each genome, and the multidomain proteins and signaling pathways of the fly and worm are far more complex than those of yeast. The fly has orthologs to 177 of the 289 human disease genes examined and provides the foundation for rapid analysis of some of the basic processes involved in human disease.

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DO - 10.1126/science.287.5461.2204

M3 - Review article

C2 - 10731134

AN - SCOPUS:0034708444

SN - 0036-8075

VL - 287

SP - 2204

EP - 2215

JO - Science

JF - Science

IS - 5461

ER -

Comparative genomics of the eukaryotes

Abstract

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