Comparative genomics of the eukaryotes

Gerald M. Rubin, Mark D. Yandell, Jennifer R. Wortman, George L. Gabor Miklos, Catherine R. Nelson, Iswar K. Hariharan, Mark E. Fortini, Peter W. Li, Rolf Apweiler, Wolfgang Fleischmann, J. Michael Cherry, Steven Henikoff, Marian P. Skupski, Sima Misra, Michael Ashburner, Ewan Birney, Mark S. Boguski, Thomas Brody, Peter Brokstein, Susan E. CelnikerStephen A. Chervitz, David Coates, Anibal Cravchik, Andrei Gabrielian, Richard F. Galle, William M. Gelbart, Reed A. George, Lawrence S.B. Goldstein, Fangcheng Gong, Ping Guan, Nomi L. Harris, Bruce A. Hay, Roger A. Hoskins, Jiayin Li, Zhenya Li, Richard O. Hynes, S. J.M. Jones, Peter M. Kuehl, Bruno Lemaitre, J. Troy Littleton, Deborah K. Morrison, Chris Mungall, Patrick H. O'Farrell, Oxana K. Pickeral, Chris Shue, Leslie B. Vosshall, Jiong Zhang, Qi Zhao, Xiangqun H. Zheng, Fei Zhong, Wenyan Zhong, Richard Gibbs, J. Craig Venter, Mark D. Adams, Suzanna Lewis

Research output: Contribution to journalReview articlepeer-review

1284 Scopus citations

Abstract

A comparative analysis of the genomes of Drosophila melanogaster, Caenorhabditis elegans, and Saccharomyces cerevisiae - and the proteins they are predicted to encode - was undertaken in the context of cellular, developmental, and evolutionary processes. The nonredundant protein sets of fries and worms are similar in size and are only twice that of yeast, but different gene families are expanded in each genome, and the multidomain proteins and signaling pathways of the fly and worm are far more complex than those of yeast. The fly has orthologs to 177 of the 289 human disease genes examined and provides the foundation for rapid analysis of some of the basic processes involved in human disease.

Original languageEnglish (US)
Pages (from-to)2204-2215
Number of pages12
JournalScience
Volume287
Issue number5461
DOIs
StatePublished - Mar 24 2000

ASJC Scopus subject areas

  • General

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