Comparative Assessment of Patient Preferences and Tolerability in Barrett Esophagus Screening: Results From a Randomized Trial

Christopher H. Blevins, Jason S. Egginton, Nilay D Shah, Michele L. Johnson, Prasad G Iyer

Research output: Contribution to journalArticle

4 Scopus citations


Goals: To determine patient preference for the Barrett esophagus (BE) screening techniques. Background: Sedated esophagogastroduodenoscopy (sEGD) and unsedated transnasal endoscopy (uTNE) are both potential techniques for BE screening. However, systematic assessment of patient preference for these 2 techniques is lacking. As part of a comparative effectiveness randomized trial of BE screening modalities, we measured short-term patient preferences for the following approaches: in-clinic uTNE (huTNE), mobile-based uTNE (muTNE), and sEGD using a novel assessment instrument. Study: Consenting community patients without known BE were randomly assigned to receive huTNE, muTNE, or sEGD, followed by a telephone administered preference and tolerability assessment instrument 24 hours after study procedures. Patient preference was measured by the waiting trade-off method. Results: In total, 201 patients completed screening with huTNE (n=71), muTNE (n=71), or sEGD (n=59), and a telephone interview. Patients’ preferences for sEGD and uTNE using the waiting trade-off method were comparable (P=0.51). Although tolerability scores were superior for sEGD (P<0.001) compared with uTNE, scores for uTNE examinations were acceptable. Conclusions: Patient preference is comparable between sEGD and uTNE for diagnostic examinations conducted in an endoscopy suite or in a mobile setting. Given acceptable tolerability, uTNE may be a viable alternative to sEGD for BE screening.

Original languageEnglish (US)
JournalJournal of Clinical Gastroenterology
StateAccepted/In press - Jan 23 2018



  • Barrett esophagus
  • esophageal adenocarcinoma
  • patient preferences
  • screening

ASJC Scopus subject areas

  • Gastroenterology

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