Companion animals

Translational scientist's new best friends

Amir Kol, Boaz Arzi, Kyriacos A. Athanasiou, Diana L. Farmer, Jan A. Nolta, Robert B. Rebhun, Xinbin Chen, Leigh Griffiths, Frank J.M. Verstraete, Christopher J. Murphy, Dori L. Borjesson

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Knowledge and resources derived from veterinary medicine represent an underused resource that could serve as a bridge between data obtained from diseases models in laboratory animals and human clinical trials. Naturally occurring disease in companion animals that display the defining attributes of similar, if not identical, diseases in humans hold promise for providing predictive proof of concept in the evaluation of new therapeutics and devices. Here we outline comparative aspects of naturally occurring diseases in companion animals and discuss their current uses in translational medicine, benefits, and shortcomings. Last, we envision how these natural models of disease might ultimately decrease the failure rate in human clinical trials and accelerate the delivery of effective treatments to the human clinical market.

Original languageEnglish (US)
Article number308ps21
JournalScience Translational Medicine
Volume7
Issue number308
DOIs
StatePublished - Oct 7 2015
Externally publishedYes

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Pets
Clinical Trials
Translational Medical Research
Veterinary Medicine
Animal Models
Equipment and Supplies
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kol, A., Arzi, B., Athanasiou, K. A., Farmer, D. L., Nolta, J. A., Rebhun, R. B., ... Borjesson, D. L. (2015). Companion animals: Translational scientist's new best friends. Science Translational Medicine, 7(308), [308ps21]. https://doi.org/10.1126/scitranslmed.aaa9116

Companion animals : Translational scientist's new best friends. / Kol, Amir; Arzi, Boaz; Athanasiou, Kyriacos A.; Farmer, Diana L.; Nolta, Jan A.; Rebhun, Robert B.; Chen, Xinbin; Griffiths, Leigh; Verstraete, Frank J.M.; Murphy, Christopher J.; Borjesson, Dori L.

In: Science Translational Medicine, Vol. 7, No. 308, 308ps21, 07.10.2015.

Research output: Contribution to journalArticle

Kol, A, Arzi, B, Athanasiou, KA, Farmer, DL, Nolta, JA, Rebhun, RB, Chen, X, Griffiths, L, Verstraete, FJM, Murphy, CJ & Borjesson, DL 2015, 'Companion animals: Translational scientist's new best friends', Science Translational Medicine, vol. 7, no. 308, 308ps21. https://doi.org/10.1126/scitranslmed.aaa9116
Kol A, Arzi B, Athanasiou KA, Farmer DL, Nolta JA, Rebhun RB et al. Companion animals: Translational scientist's new best friends. Science Translational Medicine. 2015 Oct 7;7(308). 308ps21. https://doi.org/10.1126/scitranslmed.aaa9116
Kol, Amir ; Arzi, Boaz ; Athanasiou, Kyriacos A. ; Farmer, Diana L. ; Nolta, Jan A. ; Rebhun, Robert B. ; Chen, Xinbin ; Griffiths, Leigh ; Verstraete, Frank J.M. ; Murphy, Christopher J. ; Borjesson, Dori L. / Companion animals : Translational scientist's new best friends. In: Science Translational Medicine. 2015 ; Vol. 7, No. 308.
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