TY - JOUR
T1 - Companion animals
T2 - Translational scientist's new best friends
AU - Kol, Amir
AU - Arzi, Boaz
AU - Athanasiou, Kyriacos A.
AU - Farmer, Diana L.
AU - Nolta, Jan A.
AU - Rebhun, Robert B.
AU - Chen, Xinbin
AU - Griffiths, Leigh G.
AU - Verstraete, Frank J.M.
AU - Murphy, Christopher J.
AU - Borjesson, Dori L.
PY - 2015/10/7
Y1 - 2015/10/7
N2 - Knowledge and resources derived from veterinary medicine represent an underused resource that could serve as a bridge between data obtained from diseases models in laboratory animals and human clinical trials. Naturally occurring disease in companion animals that display the defining attributes of similar, if not identical, diseases in humans hold promise for providing predictive proof of concept in the evaluation of new therapeutics and devices. Here we outline comparative aspects of naturally occurring diseases in companion animals and discuss their current uses in translational medicine, benefits, and shortcomings. Last, we envision how these natural models of disease might ultimately decrease the failure rate in human clinical trials and accelerate the delivery of effective treatments to the human clinical market.
AB - Knowledge and resources derived from veterinary medicine represent an underused resource that could serve as a bridge between data obtained from diseases models in laboratory animals and human clinical trials. Naturally occurring disease in companion animals that display the defining attributes of similar, if not identical, diseases in humans hold promise for providing predictive proof of concept in the evaluation of new therapeutics and devices. Here we outline comparative aspects of naturally occurring diseases in companion animals and discuss their current uses in translational medicine, benefits, and shortcomings. Last, we envision how these natural models of disease might ultimately decrease the failure rate in human clinical trials and accelerate the delivery of effective treatments to the human clinical market.
UR - http://www.scopus.com/inward/record.url?scp=84943619071&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84943619071&partnerID=8YFLogxK
U2 - 10.1126/scitranslmed.aaa9116
DO - 10.1126/scitranslmed.aaa9116
M3 - Article
C2 - 26446953
AN - SCOPUS:84943619071
SN - 1946-6234
VL - 7
JO - Science Translational Medicine
JF - Science Translational Medicine
IS - 308
M1 - 308ps21
ER -