Comorbid conditions and outcomes after percutaneous coronary intervention

M. Singh, Charanjit Rihal, Veronique Lee Roger, R. J. Lennon, J. Spertus, A. Jahangir, David Holmes

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Objective: To evaluate whether adding comorbid conditions to a risk model can help predict in-hospital outcome and long-term mortality after percutaneous coronary intervention (PCI). Design: Retrospective chart review Setting: Academic medical centre. Patients: 7659 patients who had 9032 PCIs. Interventions: PCI performed at Mayo Clinic between 1 January 1999 and 30 June 2004. Main outcome measures: The Mayo Clinic Risk Score (MCRS) and the coronary artery disease (CAD)-specific index for determination of comorbid conditions in all patients. Results: The mean (SD) MCRS score was 6.5 (2.9). The CAD-specific index was 0 or 1 in 46%, 2 or 3 in 30% and 4 or higher in 24%. The rate of in-hospital major adverse cardiovascular events (MACE) increased with higher MCRS and CAD-specific index (Cochran-Armitage test, p<0.001 for both models). The c-statistic for the MCRS for in-hospital MACE was 0.78; adding the CAD-specific index did not improve its discriminatory ability for inhospital MACE (c-statistic = 0.78; likelihood ratio test, p = 0.29). A total of 707 deaths after dismissal occurred after 7253 successful procedures. The c-statistic for all-cause mortality was 0.69 for the MCRS model alone and 0.75 for the MCRS and CAD-specific indices together (likelihood ratio test, p<0.001), indicating significant improvement in the discriminatory ability. Conclusions: Addition of comorbid conditions to the MCRS adds significant prognostic information for postdismissal mortality but adds little prognostic information about in-hospital complications after PCI. Such health-status measures should be included in future risk stratification models that predict long-term mortality after PCI.

Original languageEnglish (US)
Pages (from-to)1424-1428
Number of pages5
JournalHeart
Volume94
Issue number11
DOIs
StatePublished - Nov 2008

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Percutaneous Coronary Intervention
Coronary Artery Disease
Mortality
Health Status
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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Comorbid conditions and outcomes after percutaneous coronary intervention. / Singh, M.; Rihal, Charanjit; Roger, Veronique Lee; Lennon, R. J.; Spertus, J.; Jahangir, A.; Holmes, David.

In: Heart, Vol. 94, No. 11, 11.2008, p. 1424-1428.

Research output: Contribution to journalArticle

Singh, M, Rihal, C, Roger, VL, Lennon, RJ, Spertus, J, Jahangir, A & Holmes, D 2008, 'Comorbid conditions and outcomes after percutaneous coronary intervention', Heart, vol. 94, no. 11, pp. 1424-1428. https://doi.org/10.1136/hrt.2007.126649
Singh M, Rihal C, Roger VL, Lennon RJ, Spertus J, Jahangir A et al. Comorbid conditions and outcomes after percutaneous coronary intervention. Heart. 2008 Nov;94(11):1424-1428. https://doi.org/10.1136/hrt.2007.126649
Singh, M. ; Rihal, Charanjit ; Roger, Veronique Lee ; Lennon, R. J. ; Spertus, J. ; Jahangir, A. ; Holmes, David. / Comorbid conditions and outcomes after percutaneous coronary intervention. In: Heart. 2008 ; Vol. 94, No. 11. pp. 1424-1428.
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