Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and, potentially, other non-Hodgkin lymphoma subtypes

Susan L Slager, Nicola J. Camp, Lucia Conde, Tait D. Shanafelt, Sara J. Achenbach, Kari G. Rabe, Neil Elliot Kay, Anne J Novak, Timothy G. Call, Paige M. Bracci, Fenna M C Sille, Sylvia Sanchez, Nicholas K. Akers, Julie M Cunningham, Daniel J. Serie, Shannon K. McDonnell, Jose F. Leis, Alice H. Wang, J. Brice Weinberg, Martha GlennBrian Link, Celine M Vachon, Mark C. Lanasa, Christine F. Skibola, James R Cerhan

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A recent meta-analysis of three genome-wide association studies of chronic lymphocytic leukaemia (CLL) identified two common variants at the 6p21.31 locus that are associated with CLL risk. To verify and further explore the association of these variants with other non-Hodgkin lymphoma (NHL) subtypes, we genotyped 1196 CLL cases, 1699 NHL cases, and 2410 controls. We found significant associations between the 6p21.31 variants and CLL risk (rs210134: P = 0·01; rs210142: P = 6·8 × 10-3). These variants also showed a trend towards association with some of the other NHL subtypes. Our results validate the prior work and support specific genetic pathways for risk among NHL subtypes.

Original languageEnglish (US)
Pages (from-to)572-576
Number of pages5
JournalBritish Journal of Haematology
Volume159
Issue number5
DOIs
StatePublished - Dec 2012

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B-Cell Chronic Lymphocytic Leukemia
Non-Hodgkin's Lymphoma
Genome-Wide Association Study
Meta-Analysis

Keywords

  • BAK 1
  • Chronic lymphocytic leukaemia
  • Non-Hodgkin lymphoma
  • Risk locus
  • Single nucleotide polymorphisms

ASJC Scopus subject areas

  • Hematology

Cite this

Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and, potentially, other non-Hodgkin lymphoma subtypes. / Slager, Susan L; Camp, Nicola J.; Conde, Lucia; Shanafelt, Tait D.; Achenbach, Sara J.; Rabe, Kari G.; Kay, Neil Elliot; Novak, Anne J; Call, Timothy G.; Bracci, Paige M.; Sille, Fenna M C; Sanchez, Sylvia; Akers, Nicholas K.; Cunningham, Julie M; Serie, Daniel J.; McDonnell, Shannon K.; Leis, Jose F.; Wang, Alice H.; Weinberg, J. Brice; Glenn, Martha; Link, Brian; Vachon, Celine M; Lanasa, Mark C.; Skibola, Christine F.; Cerhan, James R.

In: British Journal of Haematology, Vol. 159, No. 5, 12.2012, p. 572-576.

Research output: Contribution to journalArticle

Slager, SL, Camp, NJ, Conde, L, Shanafelt, TD, Achenbach, SJ, Rabe, KG, Kay, NE, Novak, AJ, Call, TG, Bracci, PM, Sille, FMC, Sanchez, S, Akers, NK, Cunningham, JM, Serie, DJ, McDonnell, SK, Leis, JF, Wang, AH, Weinberg, JB, Glenn, M, Link, B, Vachon, CM, Lanasa, MC, Skibola, CF & Cerhan, JR 2012, 'Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and, potentially, other non-Hodgkin lymphoma subtypes', British Journal of Haematology, vol. 159, no. 5, pp. 572-576. https://doi.org/10.1111/bjh.12070
Slager, Susan L ; Camp, Nicola J. ; Conde, Lucia ; Shanafelt, Tait D. ; Achenbach, Sara J. ; Rabe, Kari G. ; Kay, Neil Elliot ; Novak, Anne J ; Call, Timothy G. ; Bracci, Paige M. ; Sille, Fenna M C ; Sanchez, Sylvia ; Akers, Nicholas K. ; Cunningham, Julie M ; Serie, Daniel J. ; McDonnell, Shannon K. ; Leis, Jose F. ; Wang, Alice H. ; Weinberg, J. Brice ; Glenn, Martha ; Link, Brian ; Vachon, Celine M ; Lanasa, Mark C. ; Skibola, Christine F. ; Cerhan, James R. / Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and, potentially, other non-Hodgkin lymphoma subtypes. In: British Journal of Haematology. 2012 ; Vol. 159, No. 5. pp. 572-576.
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abstract = "A recent meta-analysis of three genome-wide association studies of chronic lymphocytic leukaemia (CLL) identified two common variants at the 6p21.31 locus that are associated with CLL risk. To verify and further explore the association of these variants with other non-Hodgkin lymphoma (NHL) subtypes, we genotyped 1196 CLL cases, 1699 NHL cases, and 2410 controls. We found significant associations between the 6p21.31 variants and CLL risk (rs210134: P = 0·01; rs210142: P = 6·8 × 10-3). These variants also showed a trend towards association with some of the other NHL subtypes. Our results validate the prior work and support specific genetic pathways for risk among NHL subtypes.",
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AU - Bracci, Paige M.

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AU - Akers, Nicholas K.

AU - Cunningham, Julie M

AU - Serie, Daniel J.

AU - McDonnell, Shannon K.

AU - Leis, Jose F.

AU - Wang, Alice H.

AU - Weinberg, J. Brice

AU - Glenn, Martha

AU - Link, Brian

AU - Vachon, Celine M

AU - Lanasa, Mark C.

AU - Skibola, Christine F.

AU - Cerhan, James R

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