Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and, potentially, other non-Hodgkin lymphoma subtypes

Susan L. Slager, Nicola J. Camp, Lucia Conde, Tait D. Shanafelt, Sara J. Achenbach, Kari G. Rabe, Neil E. Kay, Anne J. Novak, Timothy G. Call, Paige M. Bracci, Fenna M.C. Sille, Sylvia Sanchez, Nicholas K. Akers, Julie M. Cunningham, Daniel J. Serie, Shannon K. McDonnell, Jose F. Leis, Alice H. Wang, J. Brice Weinberg, Martha GlennBrian Link, Celine M. Vachon, Mark C. Lanasa, Christine F. Skibola, James R. Cerhan

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

A recent meta-analysis of three genome-wide association studies of chronic lymphocytic leukaemia (CLL) identified two common variants at the 6p21.31 locus that are associated with CLL risk. To verify and further explore the association of these variants with other non-Hodgkin lymphoma (NHL) subtypes, we genotyped 1196 CLL cases, 1699 NHL cases, and 2410 controls. We found significant associations between the 6p21.31 variants and CLL risk (rs210134: P = 0·01; rs210142: P = 6·8 × 10-3). These variants also showed a trend towards association with some of the other NHL subtypes. Our results validate the prior work and support specific genetic pathways for risk among NHL subtypes.

Original languageEnglish (US)
Pages (from-to)572-576
Number of pages5
JournalBritish journal of haematology
Volume159
Issue number5
DOIs
StatePublished - Dec 1 2012

Keywords

  • BAK 1
  • Chronic lymphocytic leukaemia
  • Non-Hodgkin lymphoma
  • Risk locus
  • Single nucleotide polymorphisms

ASJC Scopus subject areas

  • Hematology

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    Slager, S. L., Camp, N. J., Conde, L., Shanafelt, T. D., Achenbach, S. J., Rabe, K. G., Kay, N. E., Novak, A. J., Call, T. G., Bracci, P. M., Sille, F. M. C., Sanchez, S., Akers, N. K., Cunningham, J. M., Serie, D. J., McDonnell, S. K., Leis, J. F., Wang, A. H., Weinberg, J. B., ... Cerhan, J. R. (2012). Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and, potentially, other non-Hodgkin lymphoma subtypes. British journal of haematology, 159(5), 572-576. https://doi.org/10.1111/bjh.12070