Common variants in ZNF365 are associated with both mammographic density and breast cancer risk

Sara Lindström, Celine M. Vachon, Jingmei Li, Jajini Varghese, Deborah Thompson, Ruth Warren, Judith Brown, Jean Leyland, Tina Audley, Nicholas J. Wareham, Ruth J.F. Loos, Andrew D. Paterson, Johanna Rommens, Darryl Waggott, Lisa J. Martin, Christopher G. Scott, V. Shane Pankratz, Susan E. Hankinson, Aditi Hazra, David J. HunterJohn L. Hopper, Melissa C. Southey, Stephen J. Chanock, Isabel Dos Santos Silva, Jianjun Liu, Louise Eriksson, Fergus J. Couch, Jennifer Stone, Carmel Apicella, Kamila Czene, Peter Kraft, Per Hall, Douglas F. Easton, Norman F. Boyd, Rulla M. Tamimi

Research output: Contribution to journalReview article

89 Scopus citations

Abstract

High-percent mammographic density adjusted for age and body mass index is one of the strongest risk factors for breast cancer. We conducted a meta analysis of five genome-wide association studies of percent mammographic density and report an association with rs10995190 in ZNF365 (combined P = 9.6 × 10-10). Common variants in ZNF365 have also recently been associated with susceptibility to breast cancer.

Original languageEnglish (US)
Pages (from-to)185-187
Number of pages3
JournalNature Genetics
Volume43
Issue number3
DOIs
StatePublished - Mar 1 2011

    Fingerprint

ASJC Scopus subject areas

  • Genetics

Cite this

Lindström, S., Vachon, C. M., Li, J., Varghese, J., Thompson, D., Warren, R., Brown, J., Leyland, J., Audley, T., Wareham, N. J., Loos, R. J. F., Paterson, A. D., Rommens, J., Waggott, D., Martin, L. J., Scott, C. G., Pankratz, V. S., Hankinson, S. E., Hazra, A., ... Tamimi, R. M. (2011). Common variants in ZNF365 are associated with both mammographic density and breast cancer risk. Nature Genetics, 43(3), 185-187. https://doi.org/10.1038/ng.760