Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer

Julius Gudmundsson, Patrick Sulem, Thorunn Rafnar, Jon T. Bergthorsson, Andrei Manolescu, Daniel Gudbjartsson, Bjarni A. Agnarsson, Asgeir Sigurdsson, Kristrun R. Benediktsdottir, Thorarinn Blondal, Margret Jakobsdottir, Simon N. Stacey, Jelena Kostic, Kari T. Kristinsson, Birgitta Birgisdottir, Shyamali Ghosh, Droplaug N. Magnusdottir, Steinunn Thorlacius, Gudmar Thorleifsson, S. Lilly ZhengJielin Sun, Bao Li Chang, J. Bradford Elmore, Joan P. Breyer, Kate M. McReynolds, Kevin M. Bradley, Brian L. Yaspan, Fredrik Wiklund, Par Stattin, Sara Lindström, Hans Olov Adami, Shannon K. McDonnell, Daniel J Schaid, Julie M Cunningham, Liang Wang, James R Cerhan, Jennifer St. Sauver, Sara D. Isaacs, Kathleen E. Wiley, Alan W. Partin, Patrick C. Walsh, Sonia Polo, Manuel Ruiz-Echarri, Sebastian Navarrete, Fernando Fuertes, Berta Saez, Javier Godino, Philip C. Weijerman, Dorine W. Swinkels, Katja K. Aben, J. Alfred Witjes, Brian K. Suarez, Brian T. Helfand, Michael L. Frigge, Kristleifur Kristjansson, Carole Ober, Eirikur Jonsson, Gudmundur V. Einarsson, Jianfeng Xu, Henrik Gronberg, Jeffrey R. Smith, Stephen N Thibodeau, William B. Isaacs, William J. Catalona, Jose I. Mayordomo, Lambertus A. Kiemeney, Rosa B. Barkardottir, Jeffrey R. Gulcher, Unnur Thorsteinsdottir, Augustine Kong, Kari Stefansson

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Abstract

We conducted a genome-wide SNP association study on prostate cancer on over 23,000 Icelanders, followed by a replication study including over 15,500 individuals from Europe and the United States. Two newly identified variants were shown to be associated with prostate cancer: rs5945572 on Xp11.22 and rs721048 on 2p15 (odds ratios (OR) = 1.23 and 1.15; P = 3.9 × 10 -13 and 7.7 × 10-9, respectively). The 2p15 variant shows a significantly stronger association with more aggressive, rather than less aggressive, forms of the disease.

Original languageEnglish (US)
Pages (from-to)281-283
Number of pages3
JournalNature Genetics
Volume40
Issue number3
DOIs
StatePublished - Mar 2008

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Prostatic Neoplasms
Genome-Wide Association Study
Single Nucleotide Polymorphism
Odds Ratio

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Gudmundsson, J., Sulem, P., Rafnar, T., Bergthorsson, J. T., Manolescu, A., Gudbjartsson, D., ... Stefansson, K. (2008). Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. Nature Genetics, 40(3), 281-283. https://doi.org/10.1038/ng.89

Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. / Gudmundsson, Julius; Sulem, Patrick; Rafnar, Thorunn; Bergthorsson, Jon T.; Manolescu, Andrei; Gudbjartsson, Daniel; Agnarsson, Bjarni A.; Sigurdsson, Asgeir; Benediktsdottir, Kristrun R.; Blondal, Thorarinn; Jakobsdottir, Margret; Stacey, Simon N.; Kostic, Jelena; Kristinsson, Kari T.; Birgisdottir, Birgitta; Ghosh, Shyamali; Magnusdottir, Droplaug N.; Thorlacius, Steinunn; Thorleifsson, Gudmar; Zheng, S. Lilly; Sun, Jielin; Chang, Bao Li; Elmore, J. Bradford; Breyer, Joan P.; McReynolds, Kate M.; Bradley, Kevin M.; Yaspan, Brian L.; Wiklund, Fredrik; Stattin, Par; Lindström, Sara; Adami, Hans Olov; McDonnell, Shannon K.; Schaid, Daniel J; Cunningham, Julie M; Wang, Liang; Cerhan, James R; St. Sauver, Jennifer; Isaacs, Sara D.; Wiley, Kathleen E.; Partin, Alan W.; Walsh, Patrick C.; Polo, Sonia; Ruiz-Echarri, Manuel; Navarrete, Sebastian; Fuertes, Fernando; Saez, Berta; Godino, Javier; Weijerman, Philip C.; Swinkels, Dorine W.; Aben, Katja K.; Witjes, J. Alfred; Suarez, Brian K.; Helfand, Brian T.; Frigge, Michael L.; Kristjansson, Kristleifur; Ober, Carole; Jonsson, Eirikur; Einarsson, Gudmundur V.; Xu, Jianfeng; Gronberg, Henrik; Smith, Jeffrey R.; Thibodeau, Stephen N; Isaacs, William B.; Catalona, William J.; Mayordomo, Jose I.; Kiemeney, Lambertus A.; Barkardottir, Rosa B.; Gulcher, Jeffrey R.; Thorsteinsdottir, Unnur; Kong, Augustine; Stefansson, Kari.

In: Nature Genetics, Vol. 40, No. 3, 03.2008, p. 281-283.

Research output: Contribution to journalArticle

Gudmundsson, J, Sulem, P, Rafnar, T, Bergthorsson, JT, Manolescu, A, Gudbjartsson, D, Agnarsson, BA, Sigurdsson, A, Benediktsdottir, KR, Blondal, T, Jakobsdottir, M, Stacey, SN, Kostic, J, Kristinsson, KT, Birgisdottir, B, Ghosh, S, Magnusdottir, DN, Thorlacius, S, Thorleifsson, G, Zheng, SL, Sun, J, Chang, BL, Elmore, JB, Breyer, JP, McReynolds, KM, Bradley, KM, Yaspan, BL, Wiklund, F, Stattin, P, Lindström, S, Adami, HO, McDonnell, SK, Schaid, DJ, Cunningham, JM, Wang, L, Cerhan, JR, St. Sauver, J, Isaacs, SD, Wiley, KE, Partin, AW, Walsh, PC, Polo, S, Ruiz-Echarri, M, Navarrete, S, Fuertes, F, Saez, B, Godino, J, Weijerman, PC, Swinkels, DW, Aben, KK, Witjes, JA, Suarez, BK, Helfand, BT, Frigge, ML, Kristjansson, K, Ober, C, Jonsson, E, Einarsson, GV, Xu, J, Gronberg, H, Smith, JR, Thibodeau, SN, Isaacs, WB, Catalona, WJ, Mayordomo, JI, Kiemeney, LA, Barkardottir, RB, Gulcher, JR, Thorsteinsdottir, U, Kong, A & Stefansson, K 2008, 'Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer', Nature Genetics, vol. 40, no. 3, pp. 281-283. https://doi.org/10.1038/ng.89
Gudmundsson J, Sulem P, Rafnar T, Bergthorsson JT, Manolescu A, Gudbjartsson D et al. Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. Nature Genetics. 2008 Mar;40(3):281-283. https://doi.org/10.1038/ng.89
Gudmundsson, Julius ; Sulem, Patrick ; Rafnar, Thorunn ; Bergthorsson, Jon T. ; Manolescu, Andrei ; Gudbjartsson, Daniel ; Agnarsson, Bjarni A. ; Sigurdsson, Asgeir ; Benediktsdottir, Kristrun R. ; Blondal, Thorarinn ; Jakobsdottir, Margret ; Stacey, Simon N. ; Kostic, Jelena ; Kristinsson, Kari T. ; Birgisdottir, Birgitta ; Ghosh, Shyamali ; Magnusdottir, Droplaug N. ; Thorlacius, Steinunn ; Thorleifsson, Gudmar ; Zheng, S. Lilly ; Sun, Jielin ; Chang, Bao Li ; Elmore, J. Bradford ; Breyer, Joan P. ; McReynolds, Kate M. ; Bradley, Kevin M. ; Yaspan, Brian L. ; Wiklund, Fredrik ; Stattin, Par ; Lindström, Sara ; Adami, Hans Olov ; McDonnell, Shannon K. ; Schaid, Daniel J ; Cunningham, Julie M ; Wang, Liang ; Cerhan, James R ; St. Sauver, Jennifer ; Isaacs, Sara D. ; Wiley, Kathleen E. ; Partin, Alan W. ; Walsh, Patrick C. ; Polo, Sonia ; Ruiz-Echarri, Manuel ; Navarrete, Sebastian ; Fuertes, Fernando ; Saez, Berta ; Godino, Javier ; Weijerman, Philip C. ; Swinkels, Dorine W. ; Aben, Katja K. ; Witjes, J. Alfred ; Suarez, Brian K. ; Helfand, Brian T. ; Frigge, Michael L. ; Kristjansson, Kristleifur ; Ober, Carole ; Jonsson, Eirikur ; Einarsson, Gudmundur V. ; Xu, Jianfeng ; Gronberg, Henrik ; Smith, Jeffrey R. ; Thibodeau, Stephen N ; Isaacs, William B. ; Catalona, William J. ; Mayordomo, Jose I. ; Kiemeney, Lambertus A. ; Barkardottir, Rosa B. ; Gulcher, Jeffrey R. ; Thorsteinsdottir, Unnur ; Kong, Augustine ; Stefansson, Kari. / Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. In: Nature Genetics. 2008 ; Vol. 40, No. 3. pp. 281-283.
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