Abstract
We conducted a genome-wide SNP association study on prostate cancer on over 23,000 Icelanders, followed by a replication study including over 15,500 individuals from Europe and the United States. Two newly identified variants were shown to be associated with prostate cancer: rs5945572 on Xp11.22 and rs721048 on 2p15 (odds ratios (OR) = 1.23 and 1.15; P = 3.9 × 10 -13 and 7.7 × 10-9, respectively). The 2p15 variant shows a significantly stronger association with more aggressive, rather than less aggressive, forms of the disease.
Original language | English (US) |
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Pages (from-to) | 281-283 |
Number of pages | 3 |
Journal | Nature Genetics |
Volume | 40 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2008 |
ASJC Scopus subject areas
- Genetics