Common musculoskeletal tumors of childhood and adolescence

Carola A.S. Arndt, Peter S. Rose, Andrew L. Folpe, Nadia N Laack

Research output: Contribution to journalArticle

131 Citations (Scopus)

Abstract

Osteosarcoma, Ewing sarcoma, and rhabdomyosarcoma are the most common malignant musculoskeletal tumors in children and adolescents. Today, most patients can be cured. Numerous factors have contributed to improved outcome for these patients over the past several decades. These include multidisciplinary care involving oncologists, radiation oncologists, surgeons, pathologists, and radiologists and enrollment of patients in clinical trials. Better understanding of molecular mechanisms of disease have resulted in studies using molecular targets in addition to standard chemotherapeutic agents, which hopefully will lead to better outcomes in the future. Moreover, new orthopedic techniques and devices as well as new technologies in radiation oncology hold promise for better local control of primary tumors and the potential for fewer late adverse effects. Despite this progress, patients must undergo lifelong follow-up for possible late effects of intense chemotherapy and radiation therapy.Wereview the diagnosis, prognosis, staging, multidisciplinary therapy, new directions in therapy, and long-term complications of treatment for these tumors. For this review, we searched MEDLINE using the terms rhabdomyosarcoma, osteosarcoma, Ewing sarcoma, biology, and humans and limited the search to articles from 2000 to September 2011. Additional references found in these articles were utilized as appropriate, as well as references from the background information in current therapeutic studies of the Children's Oncology Group. The same database and time frame were searched for articles written by leading authorities in the field.

Original languageEnglish (US)
Pages (from-to)475-487
Number of pages13
JournalMayo Clinic Proceedings
Volume87
Issue number5
DOIs
StatePublished - 2012

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Ewing's Sarcoma
Rhabdomyosarcoma
Osteosarcoma
Neoplasms
Radiation Oncology
Therapeutics
MEDLINE
Orthopedics
Radiotherapy
Clinical Trials
Databases
Technology
Drug Therapy
Equipment and Supplies
Radiologists
Surgeons
Oncologists
Radiation Oncologists
Direction compound
Pathologists

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Common musculoskeletal tumors of childhood and adolescence. / Arndt, Carola A.S.; Rose, Peter S.; Folpe, Andrew L.; Laack, Nadia N.

In: Mayo Clinic Proceedings, Vol. 87, No. 5, 2012, p. 475-487.

Research output: Contribution to journalArticle

Arndt, Carola A.S. ; Rose, Peter S. ; Folpe, Andrew L. ; Laack, Nadia N. / Common musculoskeletal tumors of childhood and adolescence. In: Mayo Clinic Proceedings. 2012 ; Vol. 87, No. 5. pp. 475-487.
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