Common germline polymorphisms associated with breast cancer-specific survival

Ailith Pirie, Qi Guo, Peter Kraft, Sander Canisius, Diana M. Eccles, Nazneen Rahman, Heli Nevanlinna, Constance Chen, Sofia Khan, Jonathan Tyrer, Manjeet K. Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Michael Lush, Alison M. Dunning, Mitul Shah, Kamila Czene, Hatef Darabi, Mikael ErikssonDieter Lambrechts, Caroline Weltens, Karin Leunen, Chantal van Ongeval, Børge G. Nordestgaard, Sune F. Nielsen, Henrik Flyger, Anja Rudolph, Petra Seibold, Dieter Flesch-Janys, Carl Blomqvist, Kristiina Aittomäki, Rainer Fagerholm, Taru A. Muranen, Janet E. Olsen, Emily Hallberg, Celine M Vachon, Julia A. Knight, Gord Glendon, Anna Marie Mulligan, Annegien Broeks, Sten Cornelissen, Christopher A. Haiman, Brian E. Henderson, Frederick Schumacher, Loic Le Marchand, John L. Hopper, Helen Tsimiklis, Carmel Apicella, Melissa C. Southey, Simon S. Cross, Malcolm W R Reed, Graham G. Giles, Roger L. Milne, Catriona McLean, Robert Winqvist, Katri Pylkäs, Arja Jukkola-Vuorinen, Mervi Grip, Maartje J. Hooning, Antoinette Hollestelle, John W M Martens, Ans M W van den Ouweland, Federick Marme, Andreas Schneeweiss, Rongxi Yang, Barbara Burwinkel, Jonine Figueroa, Stephen J. Chanock, Jolanta Lissowska, Elinor J. Sawyer, Ian Tomlinson, Michael J. Kerin, Nicola Miller, Hermann Brenner, Katja Butterbach, Bernd Holleczek, Vesa Kataja, Veli Matti Kosma, Jaana M. Hartikainen, Jingmei Li, Judith S. Brand, Keith Humphreys, Peter Devilee, Robert A E M Tollenaar, Caroline Seynaeve, Paolo Radice, Paolo Peterlongo, Siranoush Manoukian, Filomena Ficarazzi, Matthias W. Beckmann, Alexander Hein, Arif B. Ekici, Rosemary Balleine, Kelly Anne Phillips, Javier Benitez, M. Pilar Zamora, Jose Ignacio Arias Perez, Primitiva Menéndez, Anna Jakubowska, Jan Lubinski, Jacek Gronwald, Katarzyna Durda, Ute Hamann, Maria Kabisch, Hans Ulrich Ulmer, Thomas Rüdiger, Sara Margolin, Vessela Kristensen, Siljie Nord, D. Gareth Evans, Jean Abraham, Helena Earl, Christopher J. Poole, Louise Hiller, Janet A. Dunn, Sarah Bowden, Rose Yang, Daniele Campa, W. Ryan Diver, Susan M. Gapstur, Mia M. Gaudet, Susan Hankinson, Robert N. Hoover, Anika Hüsing, Rudolf Kaaks, Mitchell J. Machiela, Walter Willett, Myrto Barrdahl, Federico Canzian, Suet Feung Chin, Carlos Caldas, David J. Hunter, Sara Lindstrom, Montserrat Garcia-Closas, Fergus J Couch, Georgia Chenevix-Trench, Arto Mannermaa, Irene L. Andrulis, Per Hall, Jenny Chang-Claude, Douglas F. Easton, Stig E. Bojesen, Angela Cox, Peter A. Fasching, Paul D P Pharoah, Marjanka K. Schmidt

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Abstract

Introduction: Previous studies have identified common germline variants nominally associated with breast cancer survival. These associations have not been widely replicated in further studies. The purpose of this study was to evaluate the association of previously reported SNPs with breast cancer-specific survival using data from a pooled analysis of eight breast cancer survival genome-wide association studies (GWAS) from the Breast Cancer Association Consortium. Methods: A literature review was conducted of all previously published associations between common germline variants and three survival outcomes: breast cancer-specific survival, overall survival and disease-free survival. All associations that reached the nominal significance level of P value -8), these results suggest that there is some evidence of association between candidate common germline variants and breast cancer prognosis. Larger studies from multinational collaborations are necessary to increase the power to detect associations, between common variants and prognosis, at more stringent significance levels.

Original languageEnglish (US)
Article number58
JournalBreast Cancer Research
Volume17
Issue number1
DOIs
StatePublished - Apr 22 2015

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ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Pirie, A., Guo, Q., Kraft, P., Canisius, S., Eccles, D. M., Rahman, N., Nevanlinna, H., Chen, C., Khan, S., Tyrer, J., Bolla, M. K., Wang, Q., Dennis, J., Michailidou, K., Lush, M., Dunning, A. M., Shah, M., Czene, K., Darabi, H., ... Schmidt, M. K. (2015). Common germline polymorphisms associated with breast cancer-specific survival. Breast Cancer Research, 17(1), [58]. https://doi.org/10.1186/s13058-015-0570-7