Common breast cancer susceptibility loci are associated with triple-negative breast cancer

Kristen N. Stevens, Celine M Vachon, Adam M. Lee, Susan L Slager, Timothy Lesnick, Curtis Olswold, Peter A. Fasching, Penelope Miron, Diana Eccles, Jane E. Carpenter, Andrew K. Godwin, Christine Ambrosone, Robert Winqvist, Hiltrud Brauch, Marjanka K. Schmidt, Angela Cox, Simon S. Cross, Elinor Sawyer, Arndt Hartmann, Matthias W. BeckmannRud̈iger Schulz-Wendtland, Arif B. Ekici, William J. Tapper, Susan M. Gerty, Lorraine Durcan, Nikki Graham, Rebecca Hein, Stephan Nickels, Dieter Flesch-Janys, Judith Heinz, Hans Peter Sinn, Irene Konstantopoulou, Florentia Fostira, Dimitrios Pectasides, Athanasios M. Dimopoulos, George Fountzilas, Christine L. Clarke, Rosemary Balleine, Janet E Olson, Zachary Fredericksen, Robert B Diasio, Harsh Pathak, Eric Ross, JoEllen Weaver, Thomas Rüdiger, Asta Försti, Thomas Dünnebier, Foluso Ademuyiwa, Swati Kulkarni, Katri Pylkäs, Arja Jukkola-Vuorinen, Yon Dschun Ko, Erik Van Limbergen, Hilde Janssen, Julian Peto, Olivia Fletcher, Graham G. Giles, Laura Baglietto, Senno Verhoef, Ian Tomlinson, Veli Matti Kosma, Jonathan Beesley, Dario Greco, Carl Blomqvist, Astrid Irwanto, Jianjun Liu, Fiona M. Blows, Sarah Jane Dawson, Sara Margolin, Arto Mannermaa, Nicholas G. Martin, Grant W. Montgomery, Diether Lambrechts, Isabel Dos Santos Silva, Gianluca Severi, Ute Hamann, Paul Pharoah, Douglas F. Easton, Jenny Chang-Claude, Drakoulis Yannoukakos, Heli Nevanlinna, Xianshu Wang, Fergus J Couch

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

Triple-negative breast cancers are an aggressive subtype of breast cancer with poor survival, but there remains little known about the etiologic factors that promote its initiation and development. Commonly inherited breast cancer risk factors identified through genome-wide association studies display heterogeneity of effect among breast cancer subtypes as defined by the status of estrogen and progesterone receptors. In the Triple Negative Breast Cancer Consortium (TNBCC), 22 common breast cancer susceptibility variants were investigated in 2,980 Caucasian women with triple-negative breast cancer and 4,978 healthy controls. We identified six singlenucleotide polymorphisms, including rs2046210 (ESR1), rs12662670 (ESR1), rs3803662 (TOX3), rs999737 (RAD51L1), rs8170 (19p13.1), and rs8100241 (19p13.1), significantly associated with the risk of triple-negative breast cancer. Together, our results provide convincing evidence of genetic susceptibility for triple-negative breast cancer.

Original languageEnglish (US)
Pages (from-to)6240-6249
Number of pages10
JournalCancer Research
Volume71
Issue number19
DOIs
StatePublished - Oct 1 2011

Fingerprint

Triple Negative Breast Neoplasms
Breast Neoplasms
Genome-Wide Association Study
Progesterone Receptors
Genetic Predisposition to Disease
Estrogen Receptors
Survival

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Common breast cancer susceptibility loci are associated with triple-negative breast cancer. / Stevens, Kristen N.; Vachon, Celine M; Lee, Adam M.; Slager, Susan L; Lesnick, Timothy; Olswold, Curtis; Fasching, Peter A.; Miron, Penelope; Eccles, Diana; Carpenter, Jane E.; Godwin, Andrew K.; Ambrosone, Christine; Winqvist, Robert; Brauch, Hiltrud; Schmidt, Marjanka K.; Cox, Angela; Cross, Simon S.; Sawyer, Elinor; Hartmann, Arndt; Beckmann, Matthias W.; Schulz-Wendtland, Rud̈iger; Ekici, Arif B.; Tapper, William J.; Gerty, Susan M.; Durcan, Lorraine; Graham, Nikki; Hein, Rebecca; Nickels, Stephan; Flesch-Janys, Dieter; Heinz, Judith; Sinn, Hans Peter; Konstantopoulou, Irene; Fostira, Florentia; Pectasides, Dimitrios; Dimopoulos, Athanasios M.; Fountzilas, George; Clarke, Christine L.; Balleine, Rosemary; Olson, Janet E; Fredericksen, Zachary; Diasio, Robert B; Pathak, Harsh; Ross, Eric; Weaver, JoEllen; Rüdiger, Thomas; Försti, Asta; Dünnebier, Thomas; Ademuyiwa, Foluso; Kulkarni, Swati; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Ko, Yon Dschun; Van Limbergen, Erik; Janssen, Hilde; Peto, Julian; Fletcher, Olivia; Giles, Graham G.; Baglietto, Laura; Verhoef, Senno; Tomlinson, Ian; Kosma, Veli Matti; Beesley, Jonathan; Greco, Dario; Blomqvist, Carl; Irwanto, Astrid; Liu, Jianjun; Blows, Fiona M.; Dawson, Sarah Jane; Margolin, Sara; Mannermaa, Arto; Martin, Nicholas G.; Montgomery, Grant W.; Lambrechts, Diether; Dos Santos Silva, Isabel; Severi, Gianluca; Hamann, Ute; Pharoah, Paul; Easton, Douglas F.; Chang-Claude, Jenny; Yannoukakos, Drakoulis; Nevanlinna, Heli; Wang, Xianshu; Couch, Fergus J.

In: Cancer Research, Vol. 71, No. 19, 01.10.2011, p. 6240-6249.

Research output: Contribution to journalArticle

Stevens, KN, Vachon, CM, Lee, AM, Slager, SL, Lesnick, T, Olswold, C, Fasching, PA, Miron, P, Eccles, D, Carpenter, JE, Godwin, AK, Ambrosone, C, Winqvist, R, Brauch, H, Schmidt, MK, Cox, A, Cross, SS, Sawyer, E, Hartmann, A, Beckmann, MW, Schulz-Wendtland, R, Ekici, AB, Tapper, WJ, Gerty, SM, Durcan, L, Graham, N, Hein, R, Nickels, S, Flesch-Janys, D, Heinz, J, Sinn, HP, Konstantopoulou, I, Fostira, F, Pectasides, D, Dimopoulos, AM, Fountzilas, G, Clarke, CL, Balleine, R, Olson, JE, Fredericksen, Z, Diasio, RB, Pathak, H, Ross, E, Weaver, J, Rüdiger, T, Försti, A, Dünnebier, T, Ademuyiwa, F, Kulkarni, S, Pylkäs, K, Jukkola-Vuorinen, A, Ko, YD, Van Limbergen, E, Janssen, H, Peto, J, Fletcher, O, Giles, GG, Baglietto, L, Verhoef, S, Tomlinson, I, Kosma, VM, Beesley, J, Greco, D, Blomqvist, C, Irwanto, A, Liu, J, Blows, FM, Dawson, SJ, Margolin, S, Mannermaa, A, Martin, NG, Montgomery, GW, Lambrechts, D, Dos Santos Silva, I, Severi, G, Hamann, U, Pharoah, P, Easton, DF, Chang-Claude, J, Yannoukakos, D, Nevanlinna, H, Wang, X & Couch, FJ 2011, 'Common breast cancer susceptibility loci are associated with triple-negative breast cancer', Cancer Research, vol. 71, no. 19, pp. 6240-6249. https://doi.org/10.1158/0008-5472.CAN-11-1266
Stevens, Kristen N. ; Vachon, Celine M ; Lee, Adam M. ; Slager, Susan L ; Lesnick, Timothy ; Olswold, Curtis ; Fasching, Peter A. ; Miron, Penelope ; Eccles, Diana ; Carpenter, Jane E. ; Godwin, Andrew K. ; Ambrosone, Christine ; Winqvist, Robert ; Brauch, Hiltrud ; Schmidt, Marjanka K. ; Cox, Angela ; Cross, Simon S. ; Sawyer, Elinor ; Hartmann, Arndt ; Beckmann, Matthias W. ; Schulz-Wendtland, Rud̈iger ; Ekici, Arif B. ; Tapper, William J. ; Gerty, Susan M. ; Durcan, Lorraine ; Graham, Nikki ; Hein, Rebecca ; Nickels, Stephan ; Flesch-Janys, Dieter ; Heinz, Judith ; Sinn, Hans Peter ; Konstantopoulou, Irene ; Fostira, Florentia ; Pectasides, Dimitrios ; Dimopoulos, Athanasios M. ; Fountzilas, George ; Clarke, Christine L. ; Balleine, Rosemary ; Olson, Janet E ; Fredericksen, Zachary ; Diasio, Robert B ; Pathak, Harsh ; Ross, Eric ; Weaver, JoEllen ; Rüdiger, Thomas ; Försti, Asta ; Dünnebier, Thomas ; Ademuyiwa, Foluso ; Kulkarni, Swati ; Pylkäs, Katri ; Jukkola-Vuorinen, Arja ; Ko, Yon Dschun ; Van Limbergen, Erik ; Janssen, Hilde ; Peto, Julian ; Fletcher, Olivia ; Giles, Graham G. ; Baglietto, Laura ; Verhoef, Senno ; Tomlinson, Ian ; Kosma, Veli Matti ; Beesley, Jonathan ; Greco, Dario ; Blomqvist, Carl ; Irwanto, Astrid ; Liu, Jianjun ; Blows, Fiona M. ; Dawson, Sarah Jane ; Margolin, Sara ; Mannermaa, Arto ; Martin, Nicholas G. ; Montgomery, Grant W. ; Lambrechts, Diether ; Dos Santos Silva, Isabel ; Severi, Gianluca ; Hamann, Ute ; Pharoah, Paul ; Easton, Douglas F. ; Chang-Claude, Jenny ; Yannoukakos, Drakoulis ; Nevanlinna, Heli ; Wang, Xianshu ; Couch, Fergus J. / Common breast cancer susceptibility loci are associated with triple-negative breast cancer. In: Cancer Research. 2011 ; Vol. 71, No. 19. pp. 6240-6249.
@article{3e11e6fd35904a5f9792fbbcb58be0b8,
title = "Common breast cancer susceptibility loci are associated with triple-negative breast cancer",
abstract = "Triple-negative breast cancers are an aggressive subtype of breast cancer with poor survival, but there remains little known about the etiologic factors that promote its initiation and development. Commonly inherited breast cancer risk factors identified through genome-wide association studies display heterogeneity of effect among breast cancer subtypes as defined by the status of estrogen and progesterone receptors. In the Triple Negative Breast Cancer Consortium (TNBCC), 22 common breast cancer susceptibility variants were investigated in 2,980 Caucasian women with triple-negative breast cancer and 4,978 healthy controls. We identified six singlenucleotide polymorphisms, including rs2046210 (ESR1), rs12662670 (ESR1), rs3803662 (TOX3), rs999737 (RAD51L1), rs8170 (19p13.1), and rs8100241 (19p13.1), significantly associated with the risk of triple-negative breast cancer. Together, our results provide convincing evidence of genetic susceptibility for triple-negative breast cancer.",
author = "Stevens, {Kristen N.} and Vachon, {Celine M} and Lee, {Adam M.} and Slager, {Susan L} and Timothy Lesnick and Curtis Olswold and Fasching, {Peter A.} and Penelope Miron and Diana Eccles and Carpenter, {Jane E.} and Godwin, {Andrew K.} and Christine Ambrosone and Robert Winqvist and Hiltrud Brauch and Schmidt, {Marjanka K.} and Angela Cox and Cross, {Simon S.} and Elinor Sawyer and Arndt Hartmann and Beckmann, {Matthias W.} and Rud̈iger Schulz-Wendtland and Ekici, {Arif B.} and Tapper, {William J.} and Gerty, {Susan M.} and Lorraine Durcan and Nikki Graham and Rebecca Hein and Stephan Nickels and Dieter Flesch-Janys and Judith Heinz and Sinn, {Hans Peter} and Irene Konstantopoulou and Florentia Fostira and Dimitrios Pectasides and Dimopoulos, {Athanasios M.} and George Fountzilas and Clarke, {Christine L.} and Rosemary Balleine and Olson, {Janet E} and Zachary Fredericksen and Diasio, {Robert B} and Harsh Pathak and Eric Ross and JoEllen Weaver and Thomas R{\"u}diger and Asta F{\"o}rsti and Thomas D{\"u}nnebier and Foluso Ademuyiwa and Swati Kulkarni and Katri Pylk{\"a}s and Arja Jukkola-Vuorinen and Ko, {Yon Dschun} and {Van Limbergen}, Erik and Hilde Janssen and Julian Peto and Olivia Fletcher and Giles, {Graham G.} and Laura Baglietto and Senno Verhoef and Ian Tomlinson and Kosma, {Veli Matti} and Jonathan Beesley and Dario Greco and Carl Blomqvist and Astrid Irwanto and Jianjun Liu and Blows, {Fiona M.} and Dawson, {Sarah Jane} and Sara Margolin and Arto Mannermaa and Martin, {Nicholas G.} and Montgomery, {Grant W.} and Diether Lambrechts and {Dos Santos Silva}, Isabel and Gianluca Severi and Ute Hamann and Paul Pharoah and Easton, {Douglas F.} and Jenny Chang-Claude and Drakoulis Yannoukakos and Heli Nevanlinna and Xianshu Wang and Couch, {Fergus J}",
year = "2011",
month = "10",
day = "1",
doi = "10.1158/0008-5472.CAN-11-1266",
language = "English (US)",
volume = "71",
pages = "6240--6249",
journal = "Journal of Cancer Research",
issn = "0099-7013",
publisher = "American Association for Cancer Research Inc.",
number = "19",

}

TY - JOUR

T1 - Common breast cancer susceptibility loci are associated with triple-negative breast cancer

AU - Stevens, Kristen N.

AU - Vachon, Celine M

AU - Lee, Adam M.

AU - Slager, Susan L

AU - Lesnick, Timothy

AU - Olswold, Curtis

AU - Fasching, Peter A.

AU - Miron, Penelope

AU - Eccles, Diana

AU - Carpenter, Jane E.

AU - Godwin, Andrew K.

AU - Ambrosone, Christine

AU - Winqvist, Robert

AU - Brauch, Hiltrud

AU - Schmidt, Marjanka K.

AU - Cox, Angela

AU - Cross, Simon S.

AU - Sawyer, Elinor

AU - Hartmann, Arndt

AU - Beckmann, Matthias W.

AU - Schulz-Wendtland, Rud̈iger

AU - Ekici, Arif B.

AU - Tapper, William J.

AU - Gerty, Susan M.

AU - Durcan, Lorraine

AU - Graham, Nikki

AU - Hein, Rebecca

AU - Nickels, Stephan

AU - Flesch-Janys, Dieter

AU - Heinz, Judith

AU - Sinn, Hans Peter

AU - Konstantopoulou, Irene

AU - Fostira, Florentia

AU - Pectasides, Dimitrios

AU - Dimopoulos, Athanasios M.

AU - Fountzilas, George

AU - Clarke, Christine L.

AU - Balleine, Rosemary

AU - Olson, Janet E

AU - Fredericksen, Zachary

AU - Diasio, Robert B

AU - Pathak, Harsh

AU - Ross, Eric

AU - Weaver, JoEllen

AU - Rüdiger, Thomas

AU - Försti, Asta

AU - Dünnebier, Thomas

AU - Ademuyiwa, Foluso

AU - Kulkarni, Swati

AU - Pylkäs, Katri

AU - Jukkola-Vuorinen, Arja

AU - Ko, Yon Dschun

AU - Van Limbergen, Erik

AU - Janssen, Hilde

AU - Peto, Julian

AU - Fletcher, Olivia

AU - Giles, Graham G.

AU - Baglietto, Laura

AU - Verhoef, Senno

AU - Tomlinson, Ian

AU - Kosma, Veli Matti

AU - Beesley, Jonathan

AU - Greco, Dario

AU - Blomqvist, Carl

AU - Irwanto, Astrid

AU - Liu, Jianjun

AU - Blows, Fiona M.

AU - Dawson, Sarah Jane

AU - Margolin, Sara

AU - Mannermaa, Arto

AU - Martin, Nicholas G.

AU - Montgomery, Grant W.

AU - Lambrechts, Diether

AU - Dos Santos Silva, Isabel

AU - Severi, Gianluca

AU - Hamann, Ute

AU - Pharoah, Paul

AU - Easton, Douglas F.

AU - Chang-Claude, Jenny

AU - Yannoukakos, Drakoulis

AU - Nevanlinna, Heli

AU - Wang, Xianshu

AU - Couch, Fergus J

PY - 2011/10/1

Y1 - 2011/10/1

N2 - Triple-negative breast cancers are an aggressive subtype of breast cancer with poor survival, but there remains little known about the etiologic factors that promote its initiation and development. Commonly inherited breast cancer risk factors identified through genome-wide association studies display heterogeneity of effect among breast cancer subtypes as defined by the status of estrogen and progesterone receptors. In the Triple Negative Breast Cancer Consortium (TNBCC), 22 common breast cancer susceptibility variants were investigated in 2,980 Caucasian women with triple-negative breast cancer and 4,978 healthy controls. We identified six singlenucleotide polymorphisms, including rs2046210 (ESR1), rs12662670 (ESR1), rs3803662 (TOX3), rs999737 (RAD51L1), rs8170 (19p13.1), and rs8100241 (19p13.1), significantly associated with the risk of triple-negative breast cancer. Together, our results provide convincing evidence of genetic susceptibility for triple-negative breast cancer.

AB - Triple-negative breast cancers are an aggressive subtype of breast cancer with poor survival, but there remains little known about the etiologic factors that promote its initiation and development. Commonly inherited breast cancer risk factors identified through genome-wide association studies display heterogeneity of effect among breast cancer subtypes as defined by the status of estrogen and progesterone receptors. In the Triple Negative Breast Cancer Consortium (TNBCC), 22 common breast cancer susceptibility variants were investigated in 2,980 Caucasian women with triple-negative breast cancer and 4,978 healthy controls. We identified six singlenucleotide polymorphisms, including rs2046210 (ESR1), rs12662670 (ESR1), rs3803662 (TOX3), rs999737 (RAD51L1), rs8170 (19p13.1), and rs8100241 (19p13.1), significantly associated with the risk of triple-negative breast cancer. Together, our results provide convincing evidence of genetic susceptibility for triple-negative breast cancer.

UR - http://www.scopus.com/inward/record.url?scp=80053375835&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80053375835&partnerID=8YFLogxK

U2 - 10.1158/0008-5472.CAN-11-1266

DO - 10.1158/0008-5472.CAN-11-1266

M3 - Article

C2 - 21844186

AN - SCOPUS:80053375835

VL - 71

SP - 6240

EP - 6249

JO - Journal of Cancer Research

JF - Journal of Cancer Research

SN - 0099-7013

IS - 19

ER -