Combined use of COSY and double quantum two-dimensional NMR spectroscopy for elucidation of spin systems in polymyxin B

Slobodan Macura, Narinder G. Kumar, Larry R. Brown

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Two-dimensional single quantum correlation NMR spectroscopy (COSY) and two-dimensional double quantum NMR spectroscopy (2QT) are used to study spin systems in the 1H NMR spectrum of polymyxin B. Because of different frequency relationships, the two types of two-dimensional NMR experiments are found to be highly complementary. This is demonstrated by combined use of COSY and 2QT spectroscopy to obtain a complete analysis of the complicated spectral overlap which occurs in the 1H NMR spectrum of polymyxin B.

Original languageEnglish (US)
Pages (from-to)486-492
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume117
Issue number2
DOIs
StatePublished - Dec 16 1983

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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