Combined single neuron unit activity and local field potential oscillations in a human visual recognition memory task

Michal T. Kucewicz, B. Michael Berry, Mark R. Bower, Jan Cimbalnik, Vojtech Svehlik, Squire Matthew Stead, Gregory Alan Worrell

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Goal: Activities of neuronal networks range from action potential firing of individual neurons, coordinated oscillations of local neuronal assemblies, and distributed neural populations. Here, we describe recordings using hybrid electrodes, containing both micro- and clinical macroelectrodes, to simultaneously sample both large-scale network oscillations and single neuron spiking activity in the medial temporal lobe structures of human subjects during a visual recognition memory task. We quantify and compare single neuron unit activity (SUA) with high-frequency macrofield oscillations (HFOs) for decoding visual images. Results: SUA and HFOs were recorded using hybrid electrodes containing both micro and macroelectrode contacts, implanted in patients with focal epilepsy. Decoding of image properties in different task trials was performed, analyzing SUA and HFO as point processes to capture the dynamics of neurons and their assemblies at different spatiotemporal scales, ranging from submillisecond discharges of single units to fast oscillations across large neuronal populations. Results highlight the limitations and potential complementary use of SUA and HFOs for decoding of general image properties. Conclusion: The dynamics of SUA and HFOs can be used to explore a wide range of neuronal assembly activities engaged in human memory processing. Significance: Hybrid electrodes provide a technological bridge for exploring multiscale activity, spanning individual neurons, their assemblies, and large-scale population activity reflected in local field potentials. Analysis of SUA and HFO dynamics as point processes provides a potentially useful signal processing method for exploring the neuronal correlates operating at different spatial scales.

Original languageEnglish (US)
Article number2451596
Pages (from-to)67-75
Number of pages9
JournalIEEE Transactions on Biomedical Engineering
Volume63
Issue number1
DOIs
StatePublished - Jan 1 2016

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Neurons
Data storage equipment
Decoding
Electrodes
Signal processing
Processing

Keywords

  • Cognition
  • Cognitive processing
  • Gamma oscillations
  • High-frequency oscillations
  • Hybrid electrodes
  • Intracranial recordings
  • Large-scale electrophysiology
  • Neuronal assemblies
  • Ripple oscillations

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Combined single neuron unit activity and local field potential oscillations in a human visual recognition memory task. / Kucewicz, Michal T.; Berry, B. Michael; Bower, Mark R.; Cimbalnik, Jan; Svehlik, Vojtech; Stead, Squire Matthew; Worrell, Gregory Alan.

In: IEEE Transactions on Biomedical Engineering, Vol. 63, No. 1, 2451596, 01.01.2016, p. 67-75.

Research output: Contribution to journalArticle

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