Combined sellar fibrosarcorna and prolactinoma with neuronal metaplasia: Report of a case unassociated with radiotherapy

Mario Moro; Caterina Giannini; Bernd W. Scheithauer; Ricardo V. Lloyd; Paul Restall; Carl Eagleton; Andrew J. Law; Kalman Kovacs

doi:10.1385/EP:15:2:149

Combined sellar fibrosarcorna and prolactinoma with neuronal metaplasia: Report of a case unassociated with radiotherapy

Mario Moro, Caterina Giannini, Bernd W. Scheithauer, Ricardo V. Lloyd, Paul Restall, Carl Eagleton, Andrew J. Law, Kalman Kovacs

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

We report the occurrence of a primary pituitary fibrosarcoma causally unrelated to radiotherapy, admixed in association with a prolactin cell pituitary adenoma showing neuronal metaplasia. These unique findings were associated with multiple endocrine neoplasia type 1 (MEN 1). Primary fibrosarcoma involving the sella is a very rare tumor. The majority of cases have been associated with prior irradiation of either a pituitary adenoma or a craniopharyngioma. Pituitary adenoma with neuronal metaplasia is also rare and usually occurs in the setting of acromegaly. Despite the intimate association of both elements in our lesion, no transition of adenoma to sarcoma was demonstrable by immunohistochemistry or in situ hybridization studies.

Original language	English (US)
Pages (from-to)	149-158
Number of pages	10
Journal	Endocrine Pathology
Volume	15
Issue number	2
DOIs	https://doi.org/10.1385/EP:15:2:149
State	Published - Jun 2004

Keywords

Pituitary adenoma/neuronal choristoma (PANCH)
Pituitary fibrosarcoma
Prolactin cell adenoma with neuronal metaplasia

ASJC Scopus subject areas

Pathology and Forensic Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

Access to Document

10.1385/EP:15:2:149

Fingerprint Dive into the research topics of 'Combined sellar fibrosarcorna and prolactinoma with neuronal metaplasia: Report of a case unassociated with radiotherapy'. Together they form a unique fingerprint.

Cite this

Combined sellar fibrosarcorna and prolactinoma with neuronal metaplasia : Report of a case unassociated with radiotherapy. / Moro, Mario; Giannini, Caterina; Scheithauer, Bernd W.; Lloyd, Ricardo V.; Restall, Paul; Eagleton, Carl; Law, Andrew J.; Kovacs, Kalman.

In: Endocrine Pathology, Vol. 15, No. 2, 06.2004, p. 149-158.

Research output: Contribution to journal › Article › peer-review

@article{2061e5ec00244ea381b37d7bc9fd11a1,

title = "Combined sellar fibrosarcorna and prolactinoma with neuronal metaplasia: Report of a case unassociated with radiotherapy",

abstract = "We report the occurrence of a primary pituitary fibrosarcoma causally unrelated to radiotherapy, admixed in association with a prolactin cell pituitary adenoma showing neuronal metaplasia. These unique findings were associated with multiple endocrine neoplasia type 1 (MEN 1). Primary fibrosarcoma involving the sella is a very rare tumor. The majority of cases have been associated with prior irradiation of either a pituitary adenoma or a craniopharyngioma. Pituitary adenoma with neuronal metaplasia is also rare and usually occurs in the setting of acromegaly. Despite the intimate association of both elements in our lesion, no transition of adenoma to sarcoma was demonstrable by immunohistochemistry or in situ hybridization studies.",

keywords = "Pituitary adenoma/neuronal choristoma (PANCH), Pituitary fibrosarcoma, Prolactin cell adenoma with neuronal metaplasia",

author = "Mario Moro and Caterina Giannini and Scheithauer, {Bernd W.} and Lloyd, {Ricardo V.} and Paul Restall and Carl Eagleton and Law, {Andrew J.} and Kalman Kovacs",

year = "2004",

month = jun,

doi = "10.1385/EP:15:2:149",

language = "English (US)",

volume = "15",

pages = "149--158",

journal = "Endocrine Pathology",

issn = "1046-3976",

publisher = "Humana Press",

number = "2",

}

TY - JOUR

T1 - Combined sellar fibrosarcorna and prolactinoma with neuronal metaplasia

T2 - Report of a case unassociated with radiotherapy

AU - Moro, Mario

AU - Giannini, Caterina

AU - Scheithauer, Bernd W.

AU - Lloyd, Ricardo V.

AU - Restall, Paul

AU - Eagleton, Carl

AU - Law, Andrew J.

AU - Kovacs, Kalman

PY - 2004/6

Y1 - 2004/6

N2 - We report the occurrence of a primary pituitary fibrosarcoma causally unrelated to radiotherapy, admixed in association with a prolactin cell pituitary adenoma showing neuronal metaplasia. These unique findings were associated with multiple endocrine neoplasia type 1 (MEN 1). Primary fibrosarcoma involving the sella is a very rare tumor. The majority of cases have been associated with prior irradiation of either a pituitary adenoma or a craniopharyngioma. Pituitary adenoma with neuronal metaplasia is also rare and usually occurs in the setting of acromegaly. Despite the intimate association of both elements in our lesion, no transition of adenoma to sarcoma was demonstrable by immunohistochemistry or in situ hybridization studies.

AB - We report the occurrence of a primary pituitary fibrosarcoma causally unrelated to radiotherapy, admixed in association with a prolactin cell pituitary adenoma showing neuronal metaplasia. These unique findings were associated with multiple endocrine neoplasia type 1 (MEN 1). Primary fibrosarcoma involving the sella is a very rare tumor. The majority of cases have been associated with prior irradiation of either a pituitary adenoma or a craniopharyngioma. Pituitary adenoma with neuronal metaplasia is also rare and usually occurs in the setting of acromegaly. Despite the intimate association of both elements in our lesion, no transition of adenoma to sarcoma was demonstrable by immunohistochemistry or in situ hybridization studies.

KW - Pituitary adenoma/neuronal choristoma (PANCH)

KW - Pituitary fibrosarcoma

KW - Prolactin cell adenoma with neuronal metaplasia

UR - http://www.scopus.com/inward/record.url?scp=4444382356&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4444382356&partnerID=8YFLogxK

U2 - 10.1385/EP:15:2:149

DO - 10.1385/EP:15:2:149

M3 - Article

C2 - 15299201

AN - SCOPUS:4444382356

VL - 15

SP - 149

EP - 158

JO - Endocrine Pathology

JF - Endocrine Pathology

SN - 1046-3976

IS - 2

ER -

Combined sellar fibrosarcorna and prolactinoma with neuronal metaplasia: Report of a case unassociated with radiotherapy

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this