Abstract
We report the occurrence of a primary pituitary fibrosarcoma causally unrelated to radiotherapy, admixed in association with a prolactin cell pituitary adenoma showing neuronal metaplasia. These unique findings were associated with multiple endocrine neoplasia type 1 (MEN 1). Primary fibrosarcoma involving the sella is a very rare tumor. The majority of cases have been associated with prior irradiation of either a pituitary adenoma or a craniopharyngioma. Pituitary adenoma with neuronal metaplasia is also rare and usually occurs in the setting of acromegaly. Despite the intimate association of both elements in our lesion, no transition of adenoma to sarcoma was demonstrable by immunohistochemistry or in situ hybridization studies.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 149-158 |
| Number of pages | 10 |
| Journal | Endocrine Pathology |
| Volume | 15 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 2004 |
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Keywords
- Pituitary adenoma/neuronal choristoma (PANCH)
- Pituitary fibrosarcoma
- Prolactin cell adenoma with neuronal metaplasia
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Endocrinology
- Endocrinology, Diabetes and Metabolism
Cite this
Combined sellar fibrosarcorna and prolactinoma with neuronal metaplasia : Report of a case unassociated with radiotherapy. / Moro, Mario; Giannini, Caterina; Scheithauer, Bernd W.; Lloyd, Ricardo V.; Restall, Paul; Eagleton, Carl; Law, Andrew J.; Kovacs, Kalman.
In: Endocrine Pathology, Vol. 15, No. 2, 06.2004, p. 149-158.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Combined sellar fibrosarcorna and prolactinoma with neuronal metaplasia
T2 - Report of a case unassociated with radiotherapy
AU - Moro, Mario
AU - Giannini, Caterina
AU - Scheithauer, Bernd W.
AU - Lloyd, Ricardo V.
AU - Restall, Paul
AU - Eagleton, Carl
AU - Law, Andrew J.
AU - Kovacs, Kalman
PY - 2004/6
Y1 - 2004/6
N2 - We report the occurrence of a primary pituitary fibrosarcoma causally unrelated to radiotherapy, admixed in association with a prolactin cell pituitary adenoma showing neuronal metaplasia. These unique findings were associated with multiple endocrine neoplasia type 1 (MEN 1). Primary fibrosarcoma involving the sella is a very rare tumor. The majority of cases have been associated with prior irradiation of either a pituitary adenoma or a craniopharyngioma. Pituitary adenoma with neuronal metaplasia is also rare and usually occurs in the setting of acromegaly. Despite the intimate association of both elements in our lesion, no transition of adenoma to sarcoma was demonstrable by immunohistochemistry or in situ hybridization studies.
AB - We report the occurrence of a primary pituitary fibrosarcoma causally unrelated to radiotherapy, admixed in association with a prolactin cell pituitary adenoma showing neuronal metaplasia. These unique findings were associated with multiple endocrine neoplasia type 1 (MEN 1). Primary fibrosarcoma involving the sella is a very rare tumor. The majority of cases have been associated with prior irradiation of either a pituitary adenoma or a craniopharyngioma. Pituitary adenoma with neuronal metaplasia is also rare and usually occurs in the setting of acromegaly. Despite the intimate association of both elements in our lesion, no transition of adenoma to sarcoma was demonstrable by immunohistochemistry or in situ hybridization studies.
KW - Pituitary adenoma/neuronal choristoma (PANCH)
KW - Pituitary fibrosarcoma
KW - Prolactin cell adenoma with neuronal metaplasia
UR - http://www.scopus.com/inward/record.url?scp=4444382356&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=4444382356&partnerID=8YFLogxK
U2 - 10.1385/EP:15:2:149
DO - 10.1385/EP:15:2:149
M3 - Article
VL - 15
SP - 149
EP - 158
JO - Endocrine Pathology
JF - Endocrine Pathology
SN - 1046-3976
IS - 2
ER -