Combined sellar fibrosarcorna and prolactinoma with neuronal metaplasia

Report of a case unassociated with radiotherapy

Mario Moro, Caterina Giannini, Bernd W. Scheithauer, Ricardo V. Lloyd, Paul Restall, Carl Eagleton, Andrew J. Law, Kalman Kovacs

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We report the occurrence of a primary pituitary fibrosarcoma causally unrelated to radiotherapy, admixed in association with a prolactin cell pituitary adenoma showing neuronal metaplasia. These unique findings were associated with multiple endocrine neoplasia type 1 (MEN 1). Primary fibrosarcoma involving the sella is a very rare tumor. The majority of cases have been associated with prior irradiation of either a pituitary adenoma or a craniopharyngioma. Pituitary adenoma with neuronal metaplasia is also rare and usually occurs in the setting of acromegaly. Despite the intimate association of both elements in our lesion, no transition of adenoma to sarcoma was demonstrable by immunohistochemistry or in situ hybridization studies.

Original languageEnglish (US)
Pages (from-to)149-158
Number of pages10
JournalEndocrine Pathology
Volume15
Issue number2
DOIs
StatePublished - Jun 2004

Fingerprint

Prolactinoma
Metaplasia
Pituitary Neoplasms
Radiotherapy
Fibrosarcoma
Multiple Endocrine Neoplasia Type 1
Craniopharyngioma
Acromegaly
Sarcoma
Prolactin
Adenoma
In Situ Hybridization
Immunohistochemistry
Neoplasms

Keywords

  • Pituitary adenoma/neuronal choristoma (PANCH)
  • Pituitary fibrosarcoma
  • Prolactin cell adenoma with neuronal metaplasia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Combined sellar fibrosarcorna and prolactinoma with neuronal metaplasia : Report of a case unassociated with radiotherapy. / Moro, Mario; Giannini, Caterina; Scheithauer, Bernd W.; Lloyd, Ricardo V.; Restall, Paul; Eagleton, Carl; Law, Andrew J.; Kovacs, Kalman.

In: Endocrine Pathology, Vol. 15, No. 2, 06.2004, p. 149-158.

Research output: Contribution to journalArticle

Moro, Mario ; Giannini, Caterina ; Scheithauer, Bernd W. ; Lloyd, Ricardo V. ; Restall, Paul ; Eagleton, Carl ; Law, Andrew J. ; Kovacs, Kalman. / Combined sellar fibrosarcorna and prolactinoma with neuronal metaplasia : Report of a case unassociated with radiotherapy. In: Endocrine Pathology. 2004 ; Vol. 15, No. 2. pp. 149-158.
@article{2061e5ec00244ea381b37d7bc9fd11a1,
title = "Combined sellar fibrosarcorna and prolactinoma with neuronal metaplasia: Report of a case unassociated with radiotherapy",
abstract = "We report the occurrence of a primary pituitary fibrosarcoma causally unrelated to radiotherapy, admixed in association with a prolactin cell pituitary adenoma showing neuronal metaplasia. These unique findings were associated with multiple endocrine neoplasia type 1 (MEN 1). Primary fibrosarcoma involving the sella is a very rare tumor. The majority of cases have been associated with prior irradiation of either a pituitary adenoma or a craniopharyngioma. Pituitary adenoma with neuronal metaplasia is also rare and usually occurs in the setting of acromegaly. Despite the intimate association of both elements in our lesion, no transition of adenoma to sarcoma was demonstrable by immunohistochemistry or in situ hybridization studies.",
keywords = "Pituitary adenoma/neuronal choristoma (PANCH), Pituitary fibrosarcoma, Prolactin cell adenoma with neuronal metaplasia",
author = "Mario Moro and Caterina Giannini and Scheithauer, {Bernd W.} and Lloyd, {Ricardo V.} and Paul Restall and Carl Eagleton and Law, {Andrew J.} and Kalman Kovacs",
year = "2004",
month = "6",
doi = "10.1385/EP:15:2:149",
language = "English (US)",
volume = "15",
pages = "149--158",
journal = "Endocrine Pathology",
issn = "1046-3976",
publisher = "Humana Press",
number = "2",

}

TY - JOUR

T1 - Combined sellar fibrosarcorna and prolactinoma with neuronal metaplasia

T2 - Report of a case unassociated with radiotherapy

AU - Moro, Mario

AU - Giannini, Caterina

AU - Scheithauer, Bernd W.

AU - Lloyd, Ricardo V.

AU - Restall, Paul

AU - Eagleton, Carl

AU - Law, Andrew J.

AU - Kovacs, Kalman

PY - 2004/6

Y1 - 2004/6

N2 - We report the occurrence of a primary pituitary fibrosarcoma causally unrelated to radiotherapy, admixed in association with a prolactin cell pituitary adenoma showing neuronal metaplasia. These unique findings were associated with multiple endocrine neoplasia type 1 (MEN 1). Primary fibrosarcoma involving the sella is a very rare tumor. The majority of cases have been associated with prior irradiation of either a pituitary adenoma or a craniopharyngioma. Pituitary adenoma with neuronal metaplasia is also rare and usually occurs in the setting of acromegaly. Despite the intimate association of both elements in our lesion, no transition of adenoma to sarcoma was demonstrable by immunohistochemistry or in situ hybridization studies.

AB - We report the occurrence of a primary pituitary fibrosarcoma causally unrelated to radiotherapy, admixed in association with a prolactin cell pituitary adenoma showing neuronal metaplasia. These unique findings were associated with multiple endocrine neoplasia type 1 (MEN 1). Primary fibrosarcoma involving the sella is a very rare tumor. The majority of cases have been associated with prior irradiation of either a pituitary adenoma or a craniopharyngioma. Pituitary adenoma with neuronal metaplasia is also rare and usually occurs in the setting of acromegaly. Despite the intimate association of both elements in our lesion, no transition of adenoma to sarcoma was demonstrable by immunohistochemistry or in situ hybridization studies.

KW - Pituitary adenoma/neuronal choristoma (PANCH)

KW - Pituitary fibrosarcoma

KW - Prolactin cell adenoma with neuronal metaplasia

UR - http://www.scopus.com/inward/record.url?scp=4444382356&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4444382356&partnerID=8YFLogxK

U2 - 10.1385/EP:15:2:149

DO - 10.1385/EP:15:2:149

M3 - Article

VL - 15

SP - 149

EP - 158

JO - Endocrine Pathology

JF - Endocrine Pathology

SN - 1046-3976

IS - 2

ER -