Abstract
We report the occurrence of a primary pituitary fibrosarcoma causally unrelated to radiotherapy, admixed in association with a prolactin cell pituitary adenoma showing neuronal metaplasia. These unique findings were associated with multiple endocrine neoplasia type 1 (MEN 1). Primary fibrosarcoma involving the sella is a very rare tumor. The majority of cases have been associated with prior irradiation of either a pituitary adenoma or a craniopharyngioma. Pituitary adenoma with neuronal metaplasia is also rare and usually occurs in the setting of acromegaly. Despite the intimate association of both elements in our lesion, no transition of adenoma to sarcoma was demonstrable by immunohistochemistry or in situ hybridization studies.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 149-158 |
| Number of pages | 10 |
| Journal | Endocrine Pathology |
| Volume | 15 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 1 2004 |
Keywords
- Pituitary adenoma/neuronal choristoma (PANCH)
- Pituitary fibrosarcoma
- Prolactin cell adenoma with neuronal metaplasia
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Endocrinology, Diabetes and Metabolism
- Endocrinology
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Moro, M., Giannini, C., Scheithauer, B. W., Lloyd, R. V., Restall, P., Eagleton, C., Law, A. J., & Kovacs, K. (2004). Combined sellar fibrosarcorna and prolactinoma with neuronal metaplasia: Report of a case unassociated with radiotherapy. Endocrine Pathology, 15(2), 149-158. https://doi.org/10.1385/EP:15:2:149