Combined radical radiation therapy and chemotherapy for primary squamous cell carcinoma of the anal canal

B. J. Cummings, W. D. Rider, A. R. Harwood, T. J. Keane, G. M. Thomas, C. Erlichman, S. Fine

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Radical radiation therapy (5000 rads in 20 fractions in 4 weeks) combined with iv mitomycin (10 mg/m2) and 5-FU (1000 mg/m2/24 hours for 4 days) was used to treat 13 patients with locally advanced but operable squamous cell carcinoma of the anal canal. All patients achieved local control and retained anal continence, and none developed metastases. The patients were followed from 4 to 34 months (median, 12). Severe acute gastrointestinal toxic effects were seen in three patients; the same patients had significant thrombocytopenia or leukopenia. Treatment with this combined program may allow conservative management of squamous cell carcinoma of the anal canal and should be considered as an alternative to abdominoperineal resection.

Original languageEnglish (US)
Pages (from-to)489-492
Number of pages4
JournalCancer Treatment Reports
Volume66
Issue number3
StatePublished - Sep 20 1982

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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