Combined oligodendroglioma/ pleomorphic xanthoastrocytoma: A probable collision tumor: Case report

Arie Perry, Bernd W. Scheithauer, David M. Szczesniak, John L.D. Atkinson, John T. Wald, Julie E. Hammak

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

OBJECTIVE AND IMPORTANCE: We report the first case of combined oligodendroglioma and pleomorphic xanthoastrocytoma. CLINICAL PRESENTATION: A female college student and competitive cross-country runner presented to the Mayo Clinic at age 18 years with complaints of progressive headache and visual disturbances. Neuroimaging revealed a heavily calcified left parieto-occipital mass with focal enhancement and remodeling of the overlying calvarium. INTERVENTION: A histological examination of the nearly gross total resection specimen disclosed a low-grade oligodendroglioma discretely abutting a superficially situated focus of pleomorphic xanthoastrocytoma. Ten months thereafter, a recurrence was suspected on the basis of the detection of a new focus of nodular enhancement. This lesion stabilized after radiation therapy, and the patient is well, without apparent residual disease 2.8 years after surgery. CONCLUSION: This unique neoplasm is presumed to represent a collision tumor, its biological behavior being similar to that of oligodendroglioma alone. However, the possibility of an unusual, mixed oligoastrocytoma with pleomorphic xanthoastrocytoma as the astrocytic component cannot be excluded entirely. Potentially, both components have the capacity for recurrence and anaplastic transformation.

Original languageEnglish (US)
Pages (from-to)1358-1361
Number of pages4
JournalNeurosurgery
Volume48
Issue number6
StatePublished - Jun 2001

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Oligodendroglioma
Recurrence
Neoplasms
Astrocytoma
Skull
Neuroimaging
Headache
Radiotherapy
Students

Keywords

  • Brain neoplasm
  • Fluorescent in situ hybridization
  • Glioma
  • Oligodendroglioma
  • Pleomorphic xanthoastrocytoma

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Perry, A., Scheithauer, B. W., Szczesniak, D. M., Atkinson, J. L. D., Wald, J. T., & Hammak, J. E. (2001). Combined oligodendroglioma/ pleomorphic xanthoastrocytoma: A probable collision tumor: Case report. Neurosurgery, 48(6), 1358-1361.

Combined oligodendroglioma/ pleomorphic xanthoastrocytoma : A probable collision tumor: Case report. / Perry, Arie; Scheithauer, Bernd W.; Szczesniak, David M.; Atkinson, John L.D.; Wald, John T.; Hammak, Julie E.

In: Neurosurgery, Vol. 48, No. 6, 06.2001, p. 1358-1361.

Research output: Contribution to journalArticle

Perry, A, Scheithauer, BW, Szczesniak, DM, Atkinson, JLD, Wald, JT & Hammak, JE 2001, 'Combined oligodendroglioma/ pleomorphic xanthoastrocytoma: A probable collision tumor: Case report', Neurosurgery, vol. 48, no. 6, pp. 1358-1361.
Perry A, Scheithauer BW, Szczesniak DM, Atkinson JLD, Wald JT, Hammak JE. Combined oligodendroglioma/ pleomorphic xanthoastrocytoma: A probable collision tumor: Case report. Neurosurgery. 2001 Jun;48(6):1358-1361.
Perry, Arie ; Scheithauer, Bernd W. ; Szczesniak, David M. ; Atkinson, John L.D. ; Wald, John T. ; Hammak, Julie E. / Combined oligodendroglioma/ pleomorphic xanthoastrocytoma : A probable collision tumor: Case report. In: Neurosurgery. 2001 ; Vol. 48, No. 6. pp. 1358-1361.
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