Combined liver transplantation and gastric sleeve resection for patients with medically complicated obesity and end-stage liver disease

J. K. Heimbach, K. D.S. Watt, J. J. Poterucha, N. Francisco Ziller, S. D. Cecco, M. R. Charlton, J. E. Hay, R. H. Wiesner, W. Sanchez, C. B. Rosen, J. M. Swain

Research output: Contribution to journalArticlepeer-review

140 Scopus citations

Abstract

Obesity is increasingly common before and after liver transplantation (LT), yet optimal management remains unclear. Our aim was to analyze the effectiveness of a multidisciplinary protocol for obese patients requiring LT, including a noninvasive pretransplant weight loss program, and a combined LT plus sleeve gastrectomy (SG) for obese patients who failed to lose weight prior to LT. Since 2006, all patients referred LT with a BMI > 35 were enrolled. There were 37 patients who achieved weight loss and underwent LT alone, and 7 who underwent LT combined with SG. In those who received LT alone, weight gain to BMI > 35 was seen in 21/34, post-LT diabetes (DM) in 12/34, steatosis in 7/34, with 3 deaths plus 3 grafts losses. In patients undergoing the combined procedure, there were no deaths or graft losses. One patient developed a leak from the gastric staple line, and one had excess weight loss. No patients developed post-LT DM or steatosis, and all had substantial weight loss (mean BMI = 29). Noninvasive pretransplant weight loss was achieved by a majority, though weight gain post-LT was common. Combined LT plus SG resulted in effective weight loss and was associated with fewer post-LT metabolic complications. Long-term follow-up is needed. With a mean follow-up of 17 months, liver transplantation with simultaneous sleeve gastrectomy provided effective weight loss and reduced posttransplant metabolic complications.

Original languageEnglish (US)
Pages (from-to)363-368
Number of pages6
JournalAmerican Journal of Transplantation
Volume13
Issue number2
DOIs
StatePublished - Feb 2013

Keywords

  • Bariatric surgery
  • liver transplantation
  • metabolic syndrome
  • obesity
  • sleeve gastrectomy
  • weight gain

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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