Combined influence of inspiratory loading and locomotor subsystolic cuff inflation on cardiovascular responses during submaximal exercise

Joshua R. Smith, Eric J. Bruhn, Jessica D. Berg, Amran A. Nur, Nicolas Villarraga, Thomas P. Olson

Research output: Contribution to journalArticlepeer-review

Abstract

It is unknown if simultaneous stimulation of the respiratory and locomotor muscle afferents via inspiratory loading (IL) and locomotor subsystolic cuff inflation (CUFF) influences the cardiovascular responses during exercise. We hypothesized that combined IL and CUFF (IL + CUFF) will result in greater increases in blood pressure (MAP) and systemic vascular resistance (SVR) than IL and CUFF alone during exercise. Eight adults (6 males/2 females) were enrolled and performed four 10-min bouts of constant-load cycling eliciting 40% maximal oxygen uptake on a single day. For each exercise bout, the first 5 min consisted of spontaneous breathing. The second 5 min consisted of voluntary hyperventilation (i.e., breathing frequency of 40 breaths/ min) with IL (30% maximum inspiratory pressure), CUFF (80 mmHg), IL + CUFF, or no intervention (CTL) in randomized order. During exercise, cardiac output and MAP were determined via open-circuit acetylene wash-in and manual sphygmomanometry, respectively, and SVR was calculated. Across CTL, IL, CUFF, and IL + CUFF, MAP was greater with each condition (CTL: 97 ∓ 14; IL: 106 ∓ 13; CUFF: 114 ∓ 14; IL + CUFF: 119 ∓ 15 mmHg, all P ≺ 0.02). Furthermore, SVR was greater with IL + CUFF compared with IL, CUFF, and CTL (CTL: 6.6 ∓ 1.1; IL: 7.5 ∓ 1.4; CUFF: 7.5 ∓ 1.3; IL + CUFF: 8.2 ∓ 1.4 mmHg·L-1·min-1, all P ≺ 0.02). Cardiac output was not different across conditions (CTL: 15.2 ∓ 3.8; IL: 14.8 ∓ 3.7; CUFF: 15.6 ∓ 3.5; IL + CUFF: 14.7 ∓ 4.3 L/min, all P ≻ 0.05). These data demonstrate that simultaneous stimulation of respiratory and locomotor muscle afferent feedback results in additive MAP and SVR responses than IL and CUFF alone during submaximal exercise. These findings have important clinical implications for populations with exaggerated locomotor and respiratory muscle reflex feedbacks.

Original languageEnglish (US)
Pages (from-to)1338-1345
Number of pages8
JournalJournal of applied physiology
Volume128
Issue number5
DOIs
StatePublished - May 2020

Keywords

  • Blood pressure
  • Cardiac output
  • Exercise pressor reflex
  • Respiratory muscle metaboreflex
  • Venous distention

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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