Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma

Robert S. McNeill, Demitra A. Canoutas, Timothy J. Stuhlmiller, Harshil D. Dhruv, David M. Irvin, Ryan E. Bash, Steven P. Angus, Laura E. Herring, Jeremy M. Simon, Kasey R. Skinner, Juanita C. Limas, Xin Chen, Ralf S. Schmid, Marni B. Siegel, Amanda E.D. Van Swearingen, Michael J. Hadler, Erik P. Sulman, Jann N. Sarkaria, Carey K. Anders, Lee M. GravesMichael E. Berens, Gary L. Johnson, C. Ryan Miller

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