Combination of Salivary Gland Ultrasonography and Virtual Touch Quantification for Diagnosis of Sjögren's Syndrome: A Preliminary Study

Shaoqi Chen, Yukai Wang, Guohong Zhang, Shigao D Chen

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A total of 136 subjects (51 SS patients, 35 sicca syndrome patients without SS, and 50 healthy volunteers) were enrolled in this study. The mean SWV value for salivary glands of SS patients was statistically higher than that of controls (2.81 ± 0.66 m/s versus 1.85 ± 0.28 m/s for parotid glands and 2.29 ± 0.34 m/s versus 1.82 ± 0.25 m/s for submandibular glands, resp.). Combining SWV values of parotid and submandibular glands gives a sensitivity of 88.2% (95% CI: 76.1-95.6%) and specificity of 96.0% (95% CI: 86.3-99.5%) at the cutoff point of 2.19 m/s, with an AUROC of 0.954 (95% CI: 0.893-0.986). In addition, combining SGUS score and SWV value yields a sensitivity of 98.0% (95% CI: 89.6-100%), specificity of 90.0% (95% CI: 78.2-96.7%), and AUROC of 0.962 (95% CI: 0.904-0.990). Classification tree considering the sequential use of SGUS score and SWV value achieved 92.1% accuracy for diagnosis of SS. Similarly, the ROC curve of combined SGUS scores and SWV values yields an AUROC of 0.954 (95% CI: 0.885-0.987), sensitivity of 97.1% (95% CI: 85.1-99.9%), and specificity of 92.2% (95% CI: 81.1-97.8%) for separating sicca syndrome patients (without SS) from SS patients. Combining SGUS and VTQ provides a promising tool for diagnosis of SS.

Original languageEnglish (US)
Article number2793898
JournalBioMed Research International
Volume2016
DOIs
StatePublished - 2016

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Ultrasonography
Touch
Salivary Glands
Submandibular Gland
Sjogren's Syndrome
Parotid Gland
ROC Curve
Healthy Volunteers

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Combination of Salivary Gland Ultrasonography and Virtual Touch Quantification for Diagnosis of Sjögren's Syndrome : A Preliminary Study. / Chen, Shaoqi; Wang, Yukai; Zhang, Guohong; Chen, Shigao D.

In: BioMed Research International, Vol. 2016, 2793898, 2016.

Research output: Contribution to journalArticle

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title = "Combination of Salivary Gland Ultrasonography and Virtual Touch Quantification for Diagnosis of Sj{\"o}gren's Syndrome: A Preliminary Study",
abstract = "A total of 136 subjects (51 SS patients, 35 sicca syndrome patients without SS, and 50 healthy volunteers) were enrolled in this study. The mean SWV value for salivary glands of SS patients was statistically higher than that of controls (2.81 ± 0.66 m/s versus 1.85 ± 0.28 m/s for parotid glands and 2.29 ± 0.34 m/s versus 1.82 ± 0.25 m/s for submandibular glands, resp.). Combining SWV values of parotid and submandibular glands gives a sensitivity of 88.2{\%} (95{\%} CI: 76.1-95.6{\%}) and specificity of 96.0{\%} (95{\%} CI: 86.3-99.5{\%}) at the cutoff point of 2.19 m/s, with an AUROC of 0.954 (95{\%} CI: 0.893-0.986). In addition, combining SGUS score and SWV value yields a sensitivity of 98.0{\%} (95{\%} CI: 89.6-100{\%}), specificity of 90.0{\%} (95{\%} CI: 78.2-96.7{\%}), and AUROC of 0.962 (95{\%} CI: 0.904-0.990). Classification tree considering the sequential use of SGUS score and SWV value achieved 92.1{\%} accuracy for diagnosis of SS. Similarly, the ROC curve of combined SGUS scores and SWV values yields an AUROC of 0.954 (95{\%} CI: 0.885-0.987), sensitivity of 97.1{\%} (95{\%} CI: 85.1-99.9{\%}), and specificity of 92.2{\%} (95{\%} CI: 81.1-97.8{\%}) for separating sicca syndrome patients (without SS) from SS patients. Combining SGUS and VTQ provides a promising tool for diagnosis of SS.",
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AB - A total of 136 subjects (51 SS patients, 35 sicca syndrome patients without SS, and 50 healthy volunteers) were enrolled in this study. The mean SWV value for salivary glands of SS patients was statistically higher than that of controls (2.81 ± 0.66 m/s versus 1.85 ± 0.28 m/s for parotid glands and 2.29 ± 0.34 m/s versus 1.82 ± 0.25 m/s for submandibular glands, resp.). Combining SWV values of parotid and submandibular glands gives a sensitivity of 88.2% (95% CI: 76.1-95.6%) and specificity of 96.0% (95% CI: 86.3-99.5%) at the cutoff point of 2.19 m/s, with an AUROC of 0.954 (95% CI: 0.893-0.986). In addition, combining SGUS score and SWV value yields a sensitivity of 98.0% (95% CI: 89.6-100%), specificity of 90.0% (95% CI: 78.2-96.7%), and AUROC of 0.962 (95% CI: 0.904-0.990). Classification tree considering the sequential use of SGUS score and SWV value achieved 92.1% accuracy for diagnosis of SS. Similarly, the ROC curve of combined SGUS scores and SWV values yields an AUROC of 0.954 (95% CI: 0.885-0.987), sensitivity of 97.1% (95% CI: 85.1-99.9%), and specificity of 92.2% (95% CI: 81.1-97.8%) for separating sicca syndrome patients (without SS) from SS patients. Combining SGUS and VTQ provides a promising tool for diagnosis of SS.

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