Combination chemotherapy with cisplatin, vinblastine, and bleomycin for endodermal sinus tumor of the ovary

Thomas E. Davis, Charles Lawrence Loprinzi, Dolores A. Buchler

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Four consecutive patients with endodermal sinus tumor of the ovary were treated following surgery with intensive combination chemotherapy consisting of cisplatin, vinblastine, and bleomycin. All four of these patients remain continuously free of recurrent disease from 22 to 43 months following their original diagnosis. Two patients developed severe pulmonary toxicity related to the administration of bleomycin. Both of these patients also experienced Raynaud's phenomenon. The two patients whose initial surgery consisted of unilateral salpingo-oophorectomy have regular, spontaneous menstrual cycles, and one of them has become pregnant twice following the completion of chemotherapy.

Original languageEnglish (US)
Pages (from-to)46-52
Number of pages7
JournalGynecologic Oncology
Volume19
Issue number1
DOIs
StatePublished - 1984
Externally publishedYes

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Endodermal Sinus Tumor
Vinblastine
Bleomycin
Combination Drug Therapy
Cisplatin
Ovary
Raynaud Disease
Ovariectomy
Menstrual Cycle
Drug Therapy
Lung

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology

Cite this

Combination chemotherapy with cisplatin, vinblastine, and bleomycin for endodermal sinus tumor of the ovary. / Davis, Thomas E.; Loprinzi, Charles Lawrence; Buchler, Dolores A.

In: Gynecologic Oncology, Vol. 19, No. 1, 1984, p. 46-52.

Research output: Contribution to journalArticle

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