This chapter introduces the principles of comb‐push ultrasound shear elastography (CUSE), different configurations of CUSE with various ultrasound push beams, and several clinical applications using the CUSE technique. Initial clinical applications of CUSE are being conducted in breast cancer detection, thyroid nodule evaluation, and liver fibrosis staging. The chapter argues that unfocused‐CUSE (U‐CUSE) is suited for shallow shear wave imaging, focused‐CUSE (F‐CUSE) is suited for mid to deep range imaging, and marching‐CUSE (M‐CUSE) is suited for deep shear imaging. CUSE can be implemented on different types of ultrasound transducers. CUSE can be implemented on both software beamforming‐based ultrasound systems with plane wave imaging capability and hardware beamforming‐based systems with conventional a line‐by‐line scanning scheme. When combined with plane wave detection, CUSE only needs one shear wave push‐detect data acquisition to generate a full field‐of‐view (FOV) 2D shear wave speed map, which offers the highest theoretical shear wave imaging frame rate.
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