Colorectal clinical trials: What is on the horizon?

Daniel Ahn, Richard M. Goldberg

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Substantial progress has been made in the treatment of colorectal cancer, where more effective therapies have led to improved outcomes in patients with advanced disease. However, the 5-year overall survival rate remains poor. Genomic sequencing has allowed us to understand that colorectal cancer is a heterogeneous disease, where tumor-specific variants affect the prognosis and outcomes in patients. This has shaped the future directions of treatment and the development of clinical trials, including the incorporation of novel targeted therapies and investigations into the role of immunotherapy in colorectal cancer.

Original languageEnglish (US)
Pages (from-to)525-531
Number of pages7
JournalFuture Oncology
Volume12
Issue number4
DOIs
StatePublished - Feb 1 2016
Externally publishedYes

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Keywords

  • colorectal cancer
  • immunotherapy
  • next-generation sequencing
  • targeted therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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