TY - JOUR
T1 - Colorectal cancer with residual polyp of origin
T2 - A model of malignant transformation
AU - Druliner, Brooke R.
AU - Rashtak, Shahrooz
AU - Ruan, Xiaoyang
AU - Bae, Taejeong
AU - Vasmatzis, Nikolaos
AU - O’Brien, Daniel
AU - Johnson, Ruth
AU - Felmlee-Devine, Donna
AU - Washechek-Aletto, Jill
AU - Basu, Nivedita
AU - Liu, Hongfang
AU - Smyrk, Thomas
AU - Abyzov, Alexej
AU - Boardman, Lisa A.
N1 - Publisher Copyright:
© 2016 The Authors.
PY - 2016/8
Y1 - 2016/8
N2 - The majority of colorectal cancers (CRCs) arise from adenomatous polyps. In this study, we sought to present the underrecognized CRC with the residual polyp of origin (CRC RPO+) as an entity to be utilized as a model to study colorectal carcinogenesis. We identified all subjects with biopsy-proven CRC RPO+ that were evaluated over 10 years at Mayo Clinic, Rochester, MN, and compared their clinical and pathologic characteristics to CRC without remnant polyps (CRC RPO−). Overall survival and disease-free survival overlap with an equivalent hazard ratio between CRC RPO+ and RPO− cases when age, stage, and grade are adjusted. The somatic genomic profile obtained by whole genome sequencing and the gene expression profiles by RNA-seq for CRC RPO+ tumors were compared with that of age -and gender-matched CRC RPO− evaluated by The Cancer Genome Atlas. CRC RPO+ cases were more commonly found with lower-grade, earlier-stage disease than CRC RPO−. However, within the same disease stage and grade, their clinical course is very similar to that of CRC RPO−. The mutation frequencies of commonly mutated genes in CRC are similar between CRC RPO+ and RPO− cases. Likewise, gene expression patterns are indistinguishable between the RPO+ and RPO− cases. We have confirmed that CRC RPO+ is clinically and biologically similar to CRC RPO− and may be utilized as a model of the adenoma to carcinoma transition.
AB - The majority of colorectal cancers (CRCs) arise from adenomatous polyps. In this study, we sought to present the underrecognized CRC with the residual polyp of origin (CRC RPO+) as an entity to be utilized as a model to study colorectal carcinogenesis. We identified all subjects with biopsy-proven CRC RPO+ that were evaluated over 10 years at Mayo Clinic, Rochester, MN, and compared their clinical and pathologic characteristics to CRC without remnant polyps (CRC RPO−). Overall survival and disease-free survival overlap with an equivalent hazard ratio between CRC RPO+ and RPO− cases when age, stage, and grade are adjusted. The somatic genomic profile obtained by whole genome sequencing and the gene expression profiles by RNA-seq for CRC RPO+ tumors were compared with that of age -and gender-matched CRC RPO− evaluated by The Cancer Genome Atlas. CRC RPO+ cases were more commonly found with lower-grade, earlier-stage disease than CRC RPO−. However, within the same disease stage and grade, their clinical course is very similar to that of CRC RPO−. The mutation frequencies of commonly mutated genes in CRC are similar between CRC RPO+ and RPO− cases. Likewise, gene expression patterns are indistinguishable between the RPO+ and RPO− cases. We have confirmed that CRC RPO+ is clinically and biologically similar to CRC RPO− and may be utilized as a model of the adenoma to carcinoma transition.
UR - http://www.scopus.com/inward/record.url?scp=84983382754&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84983382754&partnerID=8YFLogxK
U2 - 10.1016/j.tranon.2016.06.002
DO - 10.1016/j.tranon.2016.06.002
M3 - Article
AN - SCOPUS:84983382754
SN - 1944-7124
VL - 9
SP - 280
EP - 286
JO - Translational Oncology
JF - Translational Oncology
IS - 4
ER -