Colorectal cancer with residual polyp of origin: A model of malignant transformation

Brooke R. Druliner, Shahrooz Rashtak, Xiaoyang Ruan, Taejeong Bae, Nikolaos Vasmatzis, Daniel O’Brien, Ruth Johnson, Donna Felmlee-Devine, Jill Washechek-Aletto, Nivedita Basu, Hongfang Liu, Thomas Smyrk, Alexej Abyzov, Lisa A. Boardman

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The majority of colorectal cancers (CRCs) arise from adenomatous polyps. In this study, we sought to present the underrecognized CRC with the residual polyp of origin (CRC RPO+) as an entity to be utilized as a model to study colorectal carcinogenesis. We identified all subjects with biopsy-proven CRC RPO+ that were evaluated over 10 years at Mayo Clinic, Rochester, MN, and compared their clinical and pathologic characteristics to CRC without remnant polyps (CRC RPO−). Overall survival and disease-free survival overlap with an equivalent hazard ratio between CRC RPO+ and RPO− cases when age, stage, and grade are adjusted. The somatic genomic profile obtained by whole genome sequencing and the gene expression profiles by RNA-seq for CRC RPO+ tumors were compared with that of age -and gender-matched CRC RPO− evaluated by The Cancer Genome Atlas. CRC RPO+ cases were more commonly found with lower-grade, earlier-stage disease than CRC RPO−. However, within the same disease stage and grade, their clinical course is very similar to that of CRC RPO−. The mutation frequencies of commonly mutated genes in CRC are similar between CRC RPO+ and RPO− cases. Likewise, gene expression patterns are indistinguishable between the RPO+ and RPO− cases. We have confirmed that CRC RPO+ is clinically and biologically similar to CRC RPO− and may be utilized as a model of the adenoma to carcinoma transition.

Original languageEnglish (US)
Pages (from-to)280-286
Number of pages7
JournalTranslational Oncology
Volume9
Issue number4
DOIs
StatePublished - Aug 2016

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Druliner, B. R., Rashtak, S., Ruan, X., Bae, T., Vasmatzis, N., O’Brien, D., Johnson, R., Felmlee-Devine, D., Washechek-Aletto, J., Basu, N., Liu, H., Smyrk, T., Abyzov, A., & Boardman, L. A. (2016). Colorectal cancer with residual polyp of origin: A model of malignant transformation. Translational Oncology, 9(4), 280-286. https://doi.org/10.1016/j.tranon.2016.06.002