TY - JOUR
T1 - Colorectal cancer screening and surveillance in Crohn's colitis
AU - Basseri, Robert J.
AU - Basseri, Benjamin
AU - Vassilaki, Maria E.
AU - Melmed, Gil Y.
AU - Ippoliti, Andrew
AU - Vasiliauskas, Eric A.
AU - Fleshner, Philip R.
AU - Lechago, Juan
AU - Hu, Bing
AU - Berel, Dror
AU - Targan, Stephan R.
AU - Papadakis, Konstantinos A.
PY - 2012/9
Y1 - 2012/9
N2 - Aims: To assess colonoscopic screening and surveillance for detecting neoplasia in patients with long-standing colonic Crohn's disease (CD). Patients and Methods: Colonoscopy and biopsy records from patients with colonic CD were evaluated at the Cedars-Sinai Inflammatory Bowel Disease Center during a 17-year period (1992-2009). Results: Overall, 904 screening and surveillance examinations were performed on 411 patients with Crohn's colitis (mean 2.2 examinations per patient). The screening and surveillance examinations detected neoplasia in 5.6% of the patient population; 2.7% had low-grade dysplasia (LGD) (n = 11), 0.7% had high-grade dysplasia (HGD) (n = 3), and 2.2% had carcinoma (anal carcinoma n = 3; rectal carcinoma n = 6). Mean age of CD diagnosis was 25.6 ± 0.8 years in those with normal examinations, compared to 17.7±2.7 years (p < 0.001) in those with HGD, 36.85 ± 1.43 in those with LGD (p = 0.021) and 28.32 ± 3.24 years in those with any dysplasia/cancer (p = 0.034). Disease duration in patients with normal examinations was 19.1 ± 0.5 years, compared to 36.8±4.4 years (p < 0.001) in HGD, 16.88 ± 2.59 in those with LGD (p = 0.253) and 30.68 ± 4.03 years in those with any dysplasia/cancer (p = 0.152). The mean interval between examinations was higher in HGD (31.5 ± 9.4 months) compared to those with normal colonoscopies (12.92 ± 1.250 months; p = 0.002). Conclusions: We detected cancer or dysplasia in 5.6% of patients with long-standing Crohn's colitis enrolled in a screening and surveillance program. Younger age at diagnosis of CD, longer disease course, and greater interval between exams were risk factors for the development of dysplasia.
AB - Aims: To assess colonoscopic screening and surveillance for detecting neoplasia in patients with long-standing colonic Crohn's disease (CD). Patients and Methods: Colonoscopy and biopsy records from patients with colonic CD were evaluated at the Cedars-Sinai Inflammatory Bowel Disease Center during a 17-year period (1992-2009). Results: Overall, 904 screening and surveillance examinations were performed on 411 patients with Crohn's colitis (mean 2.2 examinations per patient). The screening and surveillance examinations detected neoplasia in 5.6% of the patient population; 2.7% had low-grade dysplasia (LGD) (n = 11), 0.7% had high-grade dysplasia (HGD) (n = 3), and 2.2% had carcinoma (anal carcinoma n = 3; rectal carcinoma n = 6). Mean age of CD diagnosis was 25.6 ± 0.8 years in those with normal examinations, compared to 17.7±2.7 years (p < 0.001) in those with HGD, 36.85 ± 1.43 in those with LGD (p = 0.021) and 28.32 ± 3.24 years in those with any dysplasia/cancer (p = 0.034). Disease duration in patients with normal examinations was 19.1 ± 0.5 years, compared to 36.8±4.4 years (p < 0.001) in HGD, 16.88 ± 2.59 in those with LGD (p = 0.253) and 30.68 ± 4.03 years in those with any dysplasia/cancer (p = 0.152). The mean interval between examinations was higher in HGD (31.5 ± 9.4 months) compared to those with normal colonoscopies (12.92 ± 1.250 months; p = 0.002). Conclusions: We detected cancer or dysplasia in 5.6% of patients with long-standing Crohn's colitis enrolled in a screening and surveillance program. Younger age at diagnosis of CD, longer disease course, and greater interval between exams were risk factors for the development of dysplasia.
KW - Colorectal cancer
KW - Crohn's disease
KW - Dysplasia
KW - Inflammatory bowel disease (IBD)
KW - Screening
KW - Surveillance
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U2 - 10.1016/j.crohns.2012.01.005
DO - 10.1016/j.crohns.2012.01.005
M3 - Article
C2 - 22398087
AN - SCOPUS:84864608949
SN - 1873-9946
VL - 6
SP - 824
EP - 829
JO - Journal of Crohn's and Colitis
JF - Journal of Crohn's and Colitis
IS - 8
ER -