Colorectal cancer prognosis among patients with inflammatory bowel disease

Thierry Delaunoit, Paul John Limburg, Richard M. Goldberg, James F. Lymp, Edward Vincent Loftus, Jr

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

Background & Aims: Inflammatory bowel disease (IBD) is associated with an increased risk for colorectal cancer (CRC). However, the genetic, endoscopic, and histologic features of IBD-associated CRC differ from cancers that arise sporadically. The objectives of this study were to describe the clinicopathologic features of IBD-associated CRC and to compare survival rates between patients with IBD-associated CRC and patients with sporadic CRC. Methods: There were 290 patients with IBD-associated CRC (241 with chronic ulcerative colitis [CUC] and 49 with Crohn's disease) and an equal number of age- and sex-matched sporadic CRC patients who were evaluated at the Mayo Clinic between 1976 and 1996. Medical records were reviewed retrospectively for demographic features, endoscopic and histologic characteristics, and vital status at the time of the last follow-up evaluation. The actuarial survival of each group was calculated by the Kaplan-Meier method. The influence of clinical features on survival was assessed using Cox proportional hazards regression modeling. Results: The median age at diagnosis of IBD-related CRC was 48 years. Fifty-five percent of IBD-related tumors were distal to the splenic flexure compared with 78% of sporadic tumors. During a median follow-up period of 5 years, 163 IBD-associated CRC patients died (56%), compared with 164 sporadic CRC patients (57%). The 5-year survival rates were 54% in the IBD-CRC subgroup vs 53% in the sporadic CRC subgroup (P = .94, log-rank). Conclusions: CUC-related CRC is diagnosed at a relatively young age, and IBD-related tumors tend to be distributed more evenly across the colorectum than sporadic tumors. The survival rates for IBD-associated and sporadic CRC were similar.

Original languageEnglish (US)
Pages (from-to)335-342
Number of pages8
JournalClinical Gastroenterology and Hepatology
Volume4
Issue number3
DOIs
StatePublished - Mar 2006

Fingerprint

Inflammatory Bowel Diseases
Colorectal Neoplasms
Survival Rate
Neoplasms
Ulcerative Colitis
Transverse Colon
Survival
Crohn Disease
Medical Records
Demography

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Colorectal cancer prognosis among patients with inflammatory bowel disease. / Delaunoit, Thierry; Limburg, Paul John; Goldberg, Richard M.; Lymp, James F.; Loftus, Jr, Edward Vincent.

In: Clinical Gastroenterology and Hepatology, Vol. 4, No. 3, 03.2006, p. 335-342.

Research output: Contribution to journalArticle

@article{b8033d65b2ae4135822f783f8d74c6f6,
title = "Colorectal cancer prognosis among patients with inflammatory bowel disease",
abstract = "Background & Aims: Inflammatory bowel disease (IBD) is associated with an increased risk for colorectal cancer (CRC). However, the genetic, endoscopic, and histologic features of IBD-associated CRC differ from cancers that arise sporadically. The objectives of this study were to describe the clinicopathologic features of IBD-associated CRC and to compare survival rates between patients with IBD-associated CRC and patients with sporadic CRC. Methods: There were 290 patients with IBD-associated CRC (241 with chronic ulcerative colitis [CUC] and 49 with Crohn's disease) and an equal number of age- and sex-matched sporadic CRC patients who were evaluated at the Mayo Clinic between 1976 and 1996. Medical records were reviewed retrospectively for demographic features, endoscopic and histologic characteristics, and vital status at the time of the last follow-up evaluation. The actuarial survival of each group was calculated by the Kaplan-Meier method. The influence of clinical features on survival was assessed using Cox proportional hazards regression modeling. Results: The median age at diagnosis of IBD-related CRC was 48 years. Fifty-five percent of IBD-related tumors were distal to the splenic flexure compared with 78{\%} of sporadic tumors. During a median follow-up period of 5 years, 163 IBD-associated CRC patients died (56{\%}), compared with 164 sporadic CRC patients (57{\%}). The 5-year survival rates were 54{\%} in the IBD-CRC subgroup vs 53{\%} in the sporadic CRC subgroup (P = .94, log-rank). Conclusions: CUC-related CRC is diagnosed at a relatively young age, and IBD-related tumors tend to be distributed more evenly across the colorectum than sporadic tumors. The survival rates for IBD-associated and sporadic CRC were similar.",
author = "Thierry Delaunoit and Limburg, {Paul John} and Goldberg, {Richard M.} and Lymp, {James F.} and {Loftus, Jr}, {Edward Vincent}",
year = "2006",
month = "3",
doi = "10.1016/j.cgh.2005.12.035",
language = "English (US)",
volume = "4",
pages = "335--342",
journal = "Clinical Gastroenterology and Hepatology",
issn = "1542-3565",
publisher = "W.B. Saunders Ltd",
number = "3",

}

TY - JOUR

T1 - Colorectal cancer prognosis among patients with inflammatory bowel disease

AU - Delaunoit, Thierry

AU - Limburg, Paul John

AU - Goldberg, Richard M.

AU - Lymp, James F.

AU - Loftus, Jr, Edward Vincent

PY - 2006/3

Y1 - 2006/3

N2 - Background & Aims: Inflammatory bowel disease (IBD) is associated with an increased risk for colorectal cancer (CRC). However, the genetic, endoscopic, and histologic features of IBD-associated CRC differ from cancers that arise sporadically. The objectives of this study were to describe the clinicopathologic features of IBD-associated CRC and to compare survival rates between patients with IBD-associated CRC and patients with sporadic CRC. Methods: There were 290 patients with IBD-associated CRC (241 with chronic ulcerative colitis [CUC] and 49 with Crohn's disease) and an equal number of age- and sex-matched sporadic CRC patients who were evaluated at the Mayo Clinic between 1976 and 1996. Medical records were reviewed retrospectively for demographic features, endoscopic and histologic characteristics, and vital status at the time of the last follow-up evaluation. The actuarial survival of each group was calculated by the Kaplan-Meier method. The influence of clinical features on survival was assessed using Cox proportional hazards regression modeling. Results: The median age at diagnosis of IBD-related CRC was 48 years. Fifty-five percent of IBD-related tumors were distal to the splenic flexure compared with 78% of sporadic tumors. During a median follow-up period of 5 years, 163 IBD-associated CRC patients died (56%), compared with 164 sporadic CRC patients (57%). The 5-year survival rates were 54% in the IBD-CRC subgroup vs 53% in the sporadic CRC subgroup (P = .94, log-rank). Conclusions: CUC-related CRC is diagnosed at a relatively young age, and IBD-related tumors tend to be distributed more evenly across the colorectum than sporadic tumors. The survival rates for IBD-associated and sporadic CRC were similar.

AB - Background & Aims: Inflammatory bowel disease (IBD) is associated with an increased risk for colorectal cancer (CRC). However, the genetic, endoscopic, and histologic features of IBD-associated CRC differ from cancers that arise sporadically. The objectives of this study were to describe the clinicopathologic features of IBD-associated CRC and to compare survival rates between patients with IBD-associated CRC and patients with sporadic CRC. Methods: There were 290 patients with IBD-associated CRC (241 with chronic ulcerative colitis [CUC] and 49 with Crohn's disease) and an equal number of age- and sex-matched sporadic CRC patients who were evaluated at the Mayo Clinic between 1976 and 1996. Medical records were reviewed retrospectively for demographic features, endoscopic and histologic characteristics, and vital status at the time of the last follow-up evaluation. The actuarial survival of each group was calculated by the Kaplan-Meier method. The influence of clinical features on survival was assessed using Cox proportional hazards regression modeling. Results: The median age at diagnosis of IBD-related CRC was 48 years. Fifty-five percent of IBD-related tumors were distal to the splenic flexure compared with 78% of sporadic tumors. During a median follow-up period of 5 years, 163 IBD-associated CRC patients died (56%), compared with 164 sporadic CRC patients (57%). The 5-year survival rates were 54% in the IBD-CRC subgroup vs 53% in the sporadic CRC subgroup (P = .94, log-rank). Conclusions: CUC-related CRC is diagnosed at a relatively young age, and IBD-related tumors tend to be distributed more evenly across the colorectum than sporadic tumors. The survival rates for IBD-associated and sporadic CRC were similar.

UR - http://www.scopus.com/inward/record.url?scp=33644774339&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33644774339&partnerID=8YFLogxK

U2 - 10.1016/j.cgh.2005.12.035

DO - 10.1016/j.cgh.2005.12.035

M3 - Article

C2 - 16527697

AN - SCOPUS:33644774339

VL - 4

SP - 335

EP - 342

JO - Clinical Gastroenterology and Hepatology

JF - Clinical Gastroenterology and Hepatology

SN - 1542-3565

IS - 3

ER -