Collapsibility of Lung Volume by Paired Inspiratory and Expiratory CT Scans. Correlations with Lung Function and Mean Lung Density

Tsuneo Yamashiro, Shin Matsuoka, Brian Jack Bartholmai, Raúl San José Estépar, James C. Ross, Alejandro Diaz, Sadayuki Murayama, Edwin K. Silverman, Hiroto Hatabu, George R. Washko

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Rationale and Objectives: To evaluate the relationship between measurements of lung volume (LV) on inspiratory/expiratory computed tomography (CT) scans, pulmonary function tests (PFT), and CT measurements of emphysema in individuals with chronic obstructive pulmonary disease. Materials and Methods: Forty-six smokers (20 females and 26 males; age range 46-81 years), enrolled in the Lung Tissue Research Consortium, underwent PFT and chest CT at full inspiration and expiration. Inspiratory and expiratory LV values were automatically measured by open-source software, and the expiratory/inspiratory (E/I) ratio of LV was calculated. Mean lung density (MLD) and low attenuation area percent (<-950 HU) were also measured. Correlations of LV measurements with lung function and other CT indices were evaluated by the Spearman rank correlation test. Results: LV E/I ratio significantly correlated with the following: the percentage of predicted value of forced expiratory volume in the first second (FEV1), the ratio of FEV1 to forced vital capacity (FVC), and the ratio of residual volume (RV) to total lung capacity (TLC) (FEV1%P, R = -0.56, P < .0001; FEV1/FVC, r = -0.59, P < .0001; RV/TLC, r = 0.57, P < .0001, respectively). A higher correlation coefficient was observed between expiratory LV and expiratory MLD (r = -0.73, P < .0001) than between inspiratory LV and inspiratory MLD (r = -0.46, P < .01). LV E/I ratio showed a very strong correlation to MLD E/I ratio (r = 0.95, P < .0001). Conclusions: LV E/I ratio can be considered to be equivalent to MLD E/I ratio and to reflect airflow limitation and air-trapping. Higher collapsibility of lung volume, observed by inspiratory/expiratory CT, indicates less severe conditions in chronic obstructive pulmonary disease.

Original languageEnglish (US)
Pages (from-to)489-495
Number of pages7
JournalAcademic Radiology
Volume17
Issue number4
DOIs
StatePublished - Apr 2010

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Tomography
Lung
Lung Volume Measurements
Total Lung Capacity
Residual Volume
Respiratory Function Tests
Vital Capacity
Chronic Obstructive Pulmonary Disease
Emphysema
Forced Expiratory Volume
Thorax
Software
Air

Keywords

  • airflow obstruction
  • chronic obstructive pulmonary disease
  • computed tomography
  • Lung volume
  • pulmonary emphysema

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Collapsibility of Lung Volume by Paired Inspiratory and Expiratory CT Scans. Correlations with Lung Function and Mean Lung Density. / Yamashiro, Tsuneo; Matsuoka, Shin; Bartholmai, Brian Jack; San José Estépar, Raúl; Ross, James C.; Diaz, Alejandro; Murayama, Sadayuki; Silverman, Edwin K.; Hatabu, Hiroto; Washko, George R.

In: Academic Radiology, Vol. 17, No. 4, 04.2010, p. 489-495.

Research output: Contribution to journalArticle

Yamashiro, T, Matsuoka, S, Bartholmai, BJ, San José Estépar, R, Ross, JC, Diaz, A, Murayama, S, Silverman, EK, Hatabu, H & Washko, GR 2010, 'Collapsibility of Lung Volume by Paired Inspiratory and Expiratory CT Scans. Correlations with Lung Function and Mean Lung Density', Academic Radiology, vol. 17, no. 4, pp. 489-495. https://doi.org/10.1016/j.acra.2009.11.004
Yamashiro, Tsuneo ; Matsuoka, Shin ; Bartholmai, Brian Jack ; San José Estépar, Raúl ; Ross, James C. ; Diaz, Alejandro ; Murayama, Sadayuki ; Silverman, Edwin K. ; Hatabu, Hiroto ; Washko, George R. / Collapsibility of Lung Volume by Paired Inspiratory and Expiratory CT Scans. Correlations with Lung Function and Mean Lung Density. In: Academic Radiology. 2010 ; Vol. 17, No. 4. pp. 489-495.
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abstract = "Rationale and Objectives: To evaluate the relationship between measurements of lung volume (LV) on inspiratory/expiratory computed tomography (CT) scans, pulmonary function tests (PFT), and CT measurements of emphysema in individuals with chronic obstructive pulmonary disease. Materials and Methods: Forty-six smokers (20 females and 26 males; age range 46-81 years), enrolled in the Lung Tissue Research Consortium, underwent PFT and chest CT at full inspiration and expiration. Inspiratory and expiratory LV values were automatically measured by open-source software, and the expiratory/inspiratory (E/I) ratio of LV was calculated. Mean lung density (MLD) and low attenuation area percent (<-950 HU) were also measured. Correlations of LV measurements with lung function and other CT indices were evaluated by the Spearman rank correlation test. Results: LV E/I ratio significantly correlated with the following: the percentage of predicted value of forced expiratory volume in the first second (FEV1), the ratio of FEV1 to forced vital capacity (FVC), and the ratio of residual volume (RV) to total lung capacity (TLC) (FEV1{\%}P, R = -0.56, P < .0001; FEV1/FVC, r = -0.59, P < .0001; RV/TLC, r = 0.57, P < .0001, respectively). A higher correlation coefficient was observed between expiratory LV and expiratory MLD (r = -0.73, P < .0001) than between inspiratory LV and inspiratory MLD (r = -0.46, P < .01). LV E/I ratio showed a very strong correlation to MLD E/I ratio (r = 0.95, P < .0001). Conclusions: LV E/I ratio can be considered to be equivalent to MLD E/I ratio and to reflect airflow limitation and air-trapping. Higher collapsibility of lung volume, observed by inspiratory/expiratory CT, indicates less severe conditions in chronic obstructive pulmonary disease.",
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AU - Yamashiro, Tsuneo

AU - Matsuoka, Shin

AU - Bartholmai, Brian Jack

AU - San José Estépar, Raúl

AU - Ross, James C.

AU - Diaz, Alejandro

AU - Murayama, Sadayuki

AU - Silverman, Edwin K.

AU - Hatabu, Hiroto

AU - Washko, George R.

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N2 - Rationale and Objectives: To evaluate the relationship between measurements of lung volume (LV) on inspiratory/expiratory computed tomography (CT) scans, pulmonary function tests (PFT), and CT measurements of emphysema in individuals with chronic obstructive pulmonary disease. Materials and Methods: Forty-six smokers (20 females and 26 males; age range 46-81 years), enrolled in the Lung Tissue Research Consortium, underwent PFT and chest CT at full inspiration and expiration. Inspiratory and expiratory LV values were automatically measured by open-source software, and the expiratory/inspiratory (E/I) ratio of LV was calculated. Mean lung density (MLD) and low attenuation area percent (<-950 HU) were also measured. Correlations of LV measurements with lung function and other CT indices were evaluated by the Spearman rank correlation test. Results: LV E/I ratio significantly correlated with the following: the percentage of predicted value of forced expiratory volume in the first second (FEV1), the ratio of FEV1 to forced vital capacity (FVC), and the ratio of residual volume (RV) to total lung capacity (TLC) (FEV1%P, R = -0.56, P < .0001; FEV1/FVC, r = -0.59, P < .0001; RV/TLC, r = 0.57, P < .0001, respectively). A higher correlation coefficient was observed between expiratory LV and expiratory MLD (r = -0.73, P < .0001) than between inspiratory LV and inspiratory MLD (r = -0.46, P < .01). LV E/I ratio showed a very strong correlation to MLD E/I ratio (r = 0.95, P < .0001). Conclusions: LV E/I ratio can be considered to be equivalent to MLD E/I ratio and to reflect airflow limitation and air-trapping. Higher collapsibility of lung volume, observed by inspiratory/expiratory CT, indicates less severe conditions in chronic obstructive pulmonary disease.

AB - Rationale and Objectives: To evaluate the relationship between measurements of lung volume (LV) on inspiratory/expiratory computed tomography (CT) scans, pulmonary function tests (PFT), and CT measurements of emphysema in individuals with chronic obstructive pulmonary disease. Materials and Methods: Forty-six smokers (20 females and 26 males; age range 46-81 years), enrolled in the Lung Tissue Research Consortium, underwent PFT and chest CT at full inspiration and expiration. Inspiratory and expiratory LV values were automatically measured by open-source software, and the expiratory/inspiratory (E/I) ratio of LV was calculated. Mean lung density (MLD) and low attenuation area percent (<-950 HU) were also measured. Correlations of LV measurements with lung function and other CT indices were evaluated by the Spearman rank correlation test. Results: LV E/I ratio significantly correlated with the following: the percentage of predicted value of forced expiratory volume in the first second (FEV1), the ratio of FEV1 to forced vital capacity (FVC), and the ratio of residual volume (RV) to total lung capacity (TLC) (FEV1%P, R = -0.56, P < .0001; FEV1/FVC, r = -0.59, P < .0001; RV/TLC, r = 0.57, P < .0001, respectively). A higher correlation coefficient was observed between expiratory LV and expiratory MLD (r = -0.73, P < .0001) than between inspiratory LV and inspiratory MLD (r = -0.46, P < .01). LV E/I ratio showed a very strong correlation to MLD E/I ratio (r = 0.95, P < .0001). Conclusions: LV E/I ratio can be considered to be equivalent to MLD E/I ratio and to reflect airflow limitation and air-trapping. Higher collapsibility of lung volume, observed by inspiratory/expiratory CT, indicates less severe conditions in chronic obstructive pulmonary disease.

KW - airflow obstruction

KW - chronic obstructive pulmonary disease

KW - computed tomography

KW - Lung volume

KW - pulmonary emphysema

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