Collagenous colitis: A clinocopathologic correlation

Kenneth Ke Ning Wang, J. Perrault, H. A. Carpenter

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Collagenous colitis is an unusual cause of chronic, watery diarrhea. To characterize this disease, we reviewed biopsy specimens and the clinical records of 17 patients (9 women and 8 men) with this diagnosis. Intermittent diarrhea with symptom-free intervals lasting years was found in 7 of the 17 patients. Two patients had incapacitating arthralgias, and nine had a mild weight loss. Collagen deposition beneath the surface epithelium formed a continuous layer in 11 but was discontinuous in 5 of the 16 patients who had undergone rectal or colonic biopsies at our institution. The thickness of the collagen band was variable (maximum, 93 μm). The symptoms of the patients did niot correlate with the thickness of the collagen layer. Variability in collagen thickness may be related to disease phase and increases the need to obtain multiple biopsy specimens from the sigmoid colon and rectum. The optimal treatment for collagenous colitis is difficult to determine because three of six patients treated only symptomatically in our study had resolution of their diarrhea.

Original languageEnglish (US)
Pages (from-to)665-671
Number of pages7
JournalMayo Clinic Proceedings
Volume62
Issue number8
StatePublished - 1987
Externally publishedYes

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Collagenous Colitis
Collagen
Diarrhea
Biopsy
Arthralgia
Sigmoid Colon
Rectum
Weight Loss
Epithelium

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Wang, K. K. N., Perrault, J., & Carpenter, H. A. (1987). Collagenous colitis: A clinocopathologic correlation. Mayo Clinic Proceedings, 62(8), 665-671.

Collagenous colitis : A clinocopathologic correlation. / Wang, Kenneth Ke Ning; Perrault, J.; Carpenter, H. A.

In: Mayo Clinic Proceedings, Vol. 62, No. 8, 1987, p. 665-671.

Research output: Contribution to journalArticle

Wang, KKN, Perrault, J & Carpenter, HA 1987, 'Collagenous colitis: A clinocopathologic correlation', Mayo Clinic Proceedings, vol. 62, no. 8, pp. 665-671.
Wang, Kenneth Ke Ning ; Perrault, J. ; Carpenter, H. A. / Collagenous colitis : A clinocopathologic correlation. In: Mayo Clinic Proceedings. 1987 ; Vol. 62, No. 8. pp. 665-671.
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