Cognitive Reserve in Midlife is not Associated with Amyloid-β Deposition in Late-Life

Andreea M. Rawlings, A. Richey Sharrett, Thomas H. Mosley, Dean F. Wong, David S Knopman, Rebecca F. Gottesman

Research output: Contribution to journalArticle

Abstract

We examined associations between cognitive reserve and late-life amyloid-β deposition using florbetapir positron emission tomography (PET). We used data from the Atherosclerosis Risk in Communities (ARIC) and ARIC-PET Study. 330 dementia-free participants underwent PET scans. Mean global cortical standardized uptake value ratio (SUVR) >1.2 was defined as elevated. Midlife cognition was significantly associated with late-life cognition, but not with late-life elevated SUVR; education was not associated with late-life SUVR, but was strongly associated with late-life cognition. Cognitive reserve may reduce dementia risk by mitigating the impact of Alzheimer's disease pathology on the clinical expression of dementia, rather than by altering its pathogenesis.

Original languageEnglish (US)
Pages (from-to)517-521
Number of pages5
JournalJournal of Alzheimer's Disease
Volume68
Issue number2
DOIs
StatePublished - Jan 1 2019
Externally publishedYes

Keywords

  • Amyloid
  • cohort study
  • education
  • epidemiology
  • human
  • PET imaging

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'Cognitive Reserve in Midlife is not Associated with Amyloid-β Deposition in Late-Life'. Together they form a unique fingerprint.

  • Cite this