Abstract
We examined associations between cognitive reserve and late-life amyloid-β deposition using florbetapir positron emission tomography (PET). We used data from the Atherosclerosis Risk in Communities (ARIC) and ARIC-PET Study. 330 dementia-free participants underwent PET scans. Mean global cortical standardized uptake value ratio (SUVR) >1.2 was defined as elevated. Midlife cognition was significantly associated with late-life cognition, but not with late-life elevated SUVR; education was not associated with late-life SUVR, but was strongly associated with late-life cognition. Cognitive reserve may reduce dementia risk by mitigating the impact of Alzheimer's disease pathology on the clinical expression of dementia, rather than by altering its pathogenesis.
Original language | English (US) |
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Pages (from-to) | 517-521 |
Number of pages | 5 |
Journal | Journal of Alzheimer's Disease |
Volume | 68 |
Issue number | 2 |
DOIs | |
State | Published - 2019 |
Keywords
- Amyloid
- PET imaging
- cohort study
- education
- epidemiology
- human
ASJC Scopus subject areas
- General Neuroscience
- Clinical Psychology
- Geriatrics and Gerontology
- Psychiatry and Mental health