Abstract
Introduction: Our aim was to examine whether surgery with regional anesthesia (RA) is associated with accelerated long-term cognitive decline comparable with that previously reported after general anesthesia (GA). Methods: Longitudinal cognitive function was analyzed in a cohort of 1819 older adults. Models assessed the rate of change in global and domain-specific cognition over time in participants exposed to RA or GA. Results: When compared with those unexposed to anesthesia, the postoperative rate of change of the cognitive global z-score was greater in those exposed to both RA (difference in annual decline of −0.041, P = .011) and GA (−0.061, P < .001); these rates did not differ. In analysis of the domain-specific scores, an accelerated decline in memory was observed after GA (−0.065, P < .001) but not RA (−0.011, P = .565). Conclusions: Older adults undergoing surgery with RA experience decline of global cognition similar to those receiving GA; however, memory was not affected.
| Original language | English (US) |
|---|---|
| Journal | Alzheimer's and Dementia |
| DOIs | |
| State | Accepted/In press - Jan 1 2019 |
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Keywords
- Anesthesia: regional
- Attention/executive function
- Cognitive aging
- Cognitive z-scores
- Domains: memory
- General
- Global cognitive scores
- Language
- Mayo Clinic Study of Aging
- Older adults
- Surgery
- Visuospatial skills
ASJC Scopus subject areas
- Epidemiology
- Health Policy
- Developmental Neuroscience
- Clinical Neurology
- Geriatrics and Gerontology
- Cellular and Molecular Neuroscience
- Psychiatry and Mental health
Cite this
Cognitive function after surgery with regional or general anesthesia : A population-based study. / Sprung, Juraj; Schulte, Phillip; Knopman, David S; Mielke, Michelle M; Petersen, Ronald Carl; Weingarten, Toby N.; Martin, David P.; Hanson, Andrew C.; Schroeder, Darrell R.; Warner, David Oman.
In: Alzheimer's and Dementia, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cognitive function after surgery with regional or general anesthesia
T2 - A population-based study
AU - Sprung, Juraj
AU - Schulte, Phillip
AU - Knopman, David S
AU - Mielke, Michelle M
AU - Petersen, Ronald Carl
AU - Weingarten, Toby N.
AU - Martin, David P.
AU - Hanson, Andrew C.
AU - Schroeder, Darrell R.
AU - Warner, David Oman
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Introduction: Our aim was to examine whether surgery with regional anesthesia (RA) is associated with accelerated long-term cognitive decline comparable with that previously reported after general anesthesia (GA). Methods: Longitudinal cognitive function was analyzed in a cohort of 1819 older adults. Models assessed the rate of change in global and domain-specific cognition over time in participants exposed to RA or GA. Results: When compared with those unexposed to anesthesia, the postoperative rate of change of the cognitive global z-score was greater in those exposed to both RA (difference in annual decline of −0.041, P = .011) and GA (−0.061, P < .001); these rates did not differ. In analysis of the domain-specific scores, an accelerated decline in memory was observed after GA (−0.065, P < .001) but not RA (−0.011, P = .565). Conclusions: Older adults undergoing surgery with RA experience decline of global cognition similar to those receiving GA; however, memory was not affected.
AB - Introduction: Our aim was to examine whether surgery with regional anesthesia (RA) is associated with accelerated long-term cognitive decline comparable with that previously reported after general anesthesia (GA). Methods: Longitudinal cognitive function was analyzed in a cohort of 1819 older adults. Models assessed the rate of change in global and domain-specific cognition over time in participants exposed to RA or GA. Results: When compared with those unexposed to anesthesia, the postoperative rate of change of the cognitive global z-score was greater in those exposed to both RA (difference in annual decline of −0.041, P = .011) and GA (−0.061, P < .001); these rates did not differ. In analysis of the domain-specific scores, an accelerated decline in memory was observed after GA (−0.065, P < .001) but not RA (−0.011, P = .565). Conclusions: Older adults undergoing surgery with RA experience decline of global cognition similar to those receiving GA; however, memory was not affected.
KW - Anesthesia: regional
KW - Attention/executive function
KW - Cognitive aging
KW - Cognitive z-scores
KW - Domains: memory
KW - General
KW - Global cognitive scores
KW - Language
KW - Mayo Clinic Study of Aging
KW - Older adults
KW - Surgery
KW - Visuospatial skills
UR - http://www.scopus.com/inward/record.url?scp=85071727420&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85071727420&partnerID=8YFLogxK
U2 - 10.1016/j.jalz.2019.06.4949
DO - 10.1016/j.jalz.2019.06.4949
M3 - Article
C2 - 31495602
AN - SCOPUS:85071727420
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
SN - 1552-5260
ER -