@article{84b1844dbc2846948ab715d76b209bfc,
title = "Cognitive function after surgery with regional or general anesthesia: A population-based study",
abstract = "Introduction: Our aim was to examine whether surgery with regional anesthesia (RA) is associated with accelerated long-term cognitive decline comparable with that previously reported after general anesthesia (GA). Methods: Longitudinal cognitive function was analyzed in a cohort of 1819 older adults. Models assessed the rate of change in global and domain-specific cognition over time in participants exposed to RA or GA. Results: When compared with those unexposed to anesthesia, the postoperative rate of change of the cognitive global z-score was greater in those exposed to both RA (difference in annual decline of −0.041, P = .011) and GA (−0.061, P < .001); these rates did not differ. In analysis of the domain-specific scores, an accelerated decline in memory was observed after GA (−0.065, P < .001) but not RA (−0.011, P = .565). Conclusions: Older adults undergoing surgery with RA experience decline of global cognition similar to those receiving GA; however, memory was not affected.",
keywords = "Anesthesia: regional, Attention/executive function, Cognitive aging, Cognitive z-scores, Domains: memory, General, Global cognitive scores, Language, Mayo Clinic Study of Aging, Older adults, Surgery, Visuospatial skills",
author = "Juraj Sprung and Schulte, {Phillip J.} and Knopman, {David S.} and Mielke, {Michelle M.} and Petersen, {Ronald C.} and Weingarten, {Toby N.} and Martin, {David P.} and Hanson, {Andrew C.} and Schroeder, {Darrell R.} and Warner, {David O.}",
note = "Funding Information: This study was supported by the NIH grants P50 AG016574 and U01 AG006786 (Petersen), by the Robert H. and Clarice Smith and Abigail van Buren Alzheimer's Disease Research Program , the Rochester Epidemiology Project (R01 AG034676, Principal Investigators: Walter A. Rocca, MD, and Jennifer St. Sauver, PhD) and the Mayo Clinic Center for Translational Sciences Activities (CTSA), grant number UL1 TR000135 from the National Center for Advancing Translational Sciences (NCATS). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Financial support for statistical analyses was provided by the Department of Anesthesiology and Perioperative Medicine, Mayo Clinic . Funding Information: Disclosures: D.S.K. previously served as deputy editor for the journal Neurology , and he serves on a Data Safety Monitoring Board for Lundbeck and for the Dominantly Inherited Alzheimer Network Trials Unit. He is an investigator in clinical trials sponsored by Biogen , Eli Lilly and Co , and TauRx Therapeutics Limited and receives research support from the NIH . M.M.M. has served as a consultant for Eli Lilly and has received unrestricted research grants from Biogen and Lundbeck . R.C.P. is the chair of Data Monitoring Committees for Pfizer Inc and Janssen Alzheimer Immunotherapy, LLC, and has served as a consultant for F. Hoffmann-La Roche Ltd; Merck and Co, Inc; and Genentech Inc. He receives royalties from sales of the book Mild Cognitive Impairment (Oxford University Press). J.S., T.N.W., P.J.S., A.C.H., D.P.M., D.R.S., and D.O.W. have nothing to disclose. ",
year = "2019",
month = oct,
doi = "10.1016/j.jalz.2019.06.4949",
language = "English (US)",
volume = "15",
pages = "1243--1252",
journal = "Alzheimer's and Dementia",
issn = "1552-5260",
publisher = "Elsevier Inc.",
number = "10",
}