Cognitive asymmetries associated with apolipoprotein E genotype in patients with Alzheimer's disease

Michael J. Finton, John A. Lucas, Julie D. Rippeth, Daryl L. Bohac, Glenn E. Smith, Robert J. Ivnik, Ronald C. Petersen, Neill R. Graff-Radford

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

The relationship between apolipoprotein E (apoE) genotype and cognitive performance was examined in 200 patients with probable Alzheimer's disease (AD). Differences between composite measures of verbal and nonverbal functioning were used to define asymmetric patterns of cognition. Patients who were homozygous for apoE ε4 demonstrated relatively worse nonverbal as compared to verbal cognitive ability. In contrast, participants who were heterozygous for apoE ε4 or who possessed no ε4 allele demonstrated relatively equivalent verbal and nonverbal cognitive abilities. Although age and dementia severity also contributed to these patterns, apoE genotype appears to have a significant unique contribution to cognitive performance in these individuals. The ε4 allele may thus be associated with a specific neurocognitive phenotype among patients with AD, with the overall pattern of cognitive asymmetry dependent upon ε4 dose.

Original languageEnglish (US)
Pages (from-to)751-759
Number of pages9
JournalJournal of the International Neuropsychological Society
Volume9
Issue number5
DOIs
StatePublished - Jul 2003

Keywords

  • Alzheimer's disease
  • Apolipoprotein E
  • Cognitive asymmetry

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Clinical Neurology
  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'Cognitive asymmetries associated with apolipoprotein E genotype in patients with Alzheimer's disease'. Together they form a unique fingerprint.

  • Cite this