Coffee, caffeine-related genes, and Parkinson's disease: A case-control study

Maurizio F. Facheris, Nicole K. Schneider, Timothy G. Lesnick, Mariza de Andrade, Julie M. Cunningham, Walter A. Rocca, Demetrius M. Maraganore

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

An inverse association between coffee and Parkinson's disease (PD) has been reported. However, it remains uncertain why some but not all coffee drinkers are less susceptible to PD. We considered the possibility of a pharmacogenetic effect. In our study, we included 1,208 subjects (446 case-unaffected sibling pairs and 158 case-unrelated control pairs) recruited from an ongoing study of the molecular epidemiology of PD in the Upper Midwest (USA). We collected information on lifetime coffee drinking and we studied two genes: ADORA2A, which encodes the major receptor activity of caffeine in the brain (variants rs5751876 and rs3032740), and CYP1A2, which encodes the major rate-limiting step of caffeine metabolism (variants rs35694136 and rs762551). We did not observe significant associations of coffee drinking or of the genetic variants with PD susceptibility, either independently or jointly, in the sample overall and in most strata. Our study neither supports the hypothesis that coffee protects against PD nor provides evidence for a pharmacogenetic effect.

Original languageEnglish (US)
Pages (from-to)2033-2040
Number of pages8
JournalMovement Disorders
Volume23
Issue number14
DOIs
StatePublished - Oct 30 2008

Keywords

  • Coffee
  • Genes
  • Parkinson's disease

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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