Abstract
Aquaporin-4 (AQP4) neuromyelitis optica spectrum disorder (NMOSD) has been demonstrated to be associated with non-organ and organ-specific autoantibodies (antinuclear antibody, extractable nuclear antibody, double-stranded DNA, muscle acetylcholine receptor antibody) and systemic autoimmune diseases. In this study, we evaluated whether a similar association with non-organ and organ-specifc autoantibodies occurs in patients with MOG-IgG1-associated disorders. We determined that MOG-IgG1 was not strongly associated with these organ and non-organ-specific autoantibodies. Systemic lupus erythematous (SLE) was significantly associated with AQP4-IgG+ NMOSD and not with MOGAD (p = 0.037). These findings suggest differences in co-existing systemic and organ-specific autoimmunity between MOGAD and AQP4-IgG+ NMOSD.
Original language | English (US) |
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Pages (from-to) | 630-635 |
Number of pages | 6 |
Journal | Multiple Sclerosis Journal |
Volume | 27 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2021 |
Keywords
- AQP4-IgG neuromyelitis optica spectrum disorder
- MOG-IgG-associated disorders
- autoimmunity
- humoral immunity
- systemic lupus erythematous
ASJC Scopus subject areas
- Neurology
- Clinical Neurology