Coexisting systemic and organ-specific autoimmunity in MOG-IgG1-associated disorders versus AQP4-IgG+ NMOSD

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1 Scopus citations

Abstract

Aquaporin-4 (AQP4) neuromyelitis optica spectrum disorder (NMOSD) has been demonstrated to be associated with non-organ and organ-specific autoantibodies (antinuclear antibody, extractable nuclear antibody, double-stranded DNA, muscle acetylcholine receptor antibody) and systemic autoimmune diseases. In this study, we evaluated whether a similar association with non-organ and organ-specifc autoantibodies occurs in patients with MOG-IgG1-associated disorders. We determined that MOG-IgG1 was not strongly associated with these organ and non-organ-specific autoantibodies. Systemic lupus erythematous (SLE) was significantly associated with AQP4-IgG+ NMOSD and not with MOGAD (p = 0.037). These findings suggest differences in co-existing systemic and organ-specific autoimmunity between MOGAD and AQP4-IgG+ NMOSD.

Original languageEnglish (US)
Pages (from-to)630-635
Number of pages6
JournalMultiple Sclerosis Journal
Volume27
Issue number4
DOIs
StatePublished - Apr 2021

Keywords

  • AQP4-IgG neuromyelitis optica spectrum disorder
  • MOG-IgG-associated disorders
  • autoimmunity
  • humoral immunity
  • systemic lupus erythematous

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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