Coexistence of myasthenia gravis and serological markers of neurological autoimmunity in neuromyelitis optica

Andrew Mckeon; Vanda A. Lennon; Anu Jacob; Marcelo Matiello; Claudia F. Lucchinetti; Nilufer Kale; Koon H. Chan; Brian G. Weinshenker; Metha Apiwattinakul; Dean M. Wingerchuk; Sean J. Pittock

doi:10.1002/mus.21197

Coexistence of myasthenia gravis and serological markers of neurological autoimmunity in neuromyelitis optica

Andrew Mckeon, Vanda A. Lennon, Anu Jacob, Marcelo Matiello, Claudia F. Lucchinetti, Nilufer Kale, Koon H. Chan, Brian G. Weinshenker, Metha Apiwattinakul, Dean M. Wingerchuk, Sean J. Pittock

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103 Scopus citations

Abstract

We systematically evaluated the frequency of neurological disorders and muscle and neural autoantibodies in 177 patients with neuromyelitis optica (NMO) and in 250 control subjects (173 healthy; 77 multiple sclerosis, MS, patients). An excess of myasthenia gravis (MG, 2%), and muscle-type acetylcholine receptor antibody (11%) was detected among NMO patients. The presence of neural or muscle autoantibodies was more common in NMO patients (34%) than in MS patients or healthy controls (7%), P < 0.0001. The coexistence of NMO and MG should be considered in atypical or refractory presentations of either disorder.

Original language	English (US)
Pages (from-to)	87-90
Number of pages	4
Journal	Muscle and Nerve
Volume	39
Issue number	1
DOIs	https://doi.org/10.1002/mus.21197
State	Published - Jan 2009

Keywords

Acetylcholine receptor
Aquaporin-4
Autoantibodies
Multiple sclerosis
Muscle
Myasthenia gravis
Neural
Neuromyelitis optica
Water channel

ASJC Scopus subject areas

Physiology
Clinical Neurology
Cellular and Molecular Neuroscience
Physiology (medical)

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title = "Coexistence of myasthenia gravis and serological markers of neurological autoimmunity in neuromyelitis optica",

abstract = "We systematically evaluated the frequency of neurological disorders and muscle and neural autoantibodies in 177 patients with neuromyelitis optica (NMO) and in 250 control subjects (173 healthy; 77 multiple sclerosis, MS, patients). An excess of myasthenia gravis (MG, 2%), and muscle-type acetylcholine receptor antibody (11%) was detected among NMO patients. The presence of neural or muscle autoantibodies was more common in NMO patients (34%) than in MS patients or healthy controls (7%), P < 0.0001. The coexistence of NMO and MG should be considered in atypical or refractory presentations of either disorder.",

keywords = "Acetylcholine receptor, Aquaporin-4, Autoantibodies, Multiple sclerosis, Muscle, Myasthenia gravis, Neural, Neuromyelitis optica, Water channel",

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AU - Matiello, Marcelo

AU - Lucchinetti, Claudia F.

AU - Kale, Nilufer

AU - Chan, Koon H.

AU - Weinshenker, Brian G.

AU - Apiwattinakul, Metha

AU - Wingerchuk, Dean M.

AU - Pittock, Sean J.

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KW - Acetylcholine receptor

KW - Aquaporin-4

KW - Autoantibodies

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KW - Water channel

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Coexistence of myasthenia gravis and serological markers of neurological autoimmunity in neuromyelitis optica

Abstract

Keywords

ASJC Scopus subject areas

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