Coexistence of myasthenia gravis and serological markers of neurological autoimmunity in neuromyelitis optica

Andrew B McKeon, Vanda A Lennon, Anu Jacob, Marcelo Matiello, Claudia F Lucchinetti, Nilufer Kale, Koon H. Chan, Brian G Weinshenker, Metha Apiwattinakul, Dean Marko Wingerchuk, Sean J Pittock

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

We systematically evaluated the frequency of neurological disorders and muscle and neural autoantibodies in 177 patients with neuromyelitis optica (NMO) and in 250 control subjects (173 healthy; 77 multiple sclerosis, MS, patients). An excess of myasthenia gravis (MG, 2%), and muscle-type acetylcholine receptor antibody (11%) was detected among NMO patients. The presence of neural or muscle autoantibodies was more common in NMO patients (34%) than in MS patients or healthy controls (7%), P < 0.0001. The coexistence of NMO and MG should be considered in atypical or refractory presentations of either disorder.

Original languageEnglish (US)
Pages (from-to)87-90
Number of pages4
JournalMuscle and Nerve
Volume39
Issue number1
DOIs
StatePublished - Jan 2009

Fingerprint

Neuromyelitis Optica
Myasthenia Gravis
Autoimmunity
Muscles
Autoantibodies
Cholinergic Receptors
Nervous System Diseases
Multiple Sclerosis
Healthy Volunteers
Antibodies

Keywords

  • Acetylcholine receptor
  • Aquaporin-4
  • Autoantibodies
  • Multiple sclerosis
  • Muscle
  • Myasthenia gravis
  • Neural
  • Neuromyelitis optica
  • Water channel

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)
  • Physiology

Cite this

Coexistence of myasthenia gravis and serological markers of neurological autoimmunity in neuromyelitis optica. / McKeon, Andrew B; Lennon, Vanda A; Jacob, Anu; Matiello, Marcelo; Lucchinetti, Claudia F; Kale, Nilufer; Chan, Koon H.; Weinshenker, Brian G; Apiwattinakul, Metha; Wingerchuk, Dean Marko; Pittock, Sean J.

In: Muscle and Nerve, Vol. 39, No. 1, 01.2009, p. 87-90.

Research output: Contribution to journalArticle

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