Coeliac disease

Katri Lindfors, Carolina Ciacci, Kalle Kurppa, Knut E.A. Lundin, Govind K. Makharia, M. Luisa Mearin, Joseph A Murray, Elena F. Verdu, Katri Kaukinen

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Coeliac disease is an immune-mediated enteropathy against dietary gluten present in wheat, rye and barley and is one of the most common lifelong food-related disorders worldwide. Coeliac disease is also considered to be a systemic disorder characterized by a variable combination of gluten-related signs and symptoms and disease-specific antibodies in addition to enteropathy. The ingestion of gluten leads to the generation of harmful gluten peptides, which, in predisposed individuals, can induce adaptive and innate immune responses. The clinical presentation is extremely variable; patients may have severe gastrointestinal symptoms and malabsorption, extraintestinal symptoms or have no symptoms at all. Owing to the multifaceted clinical presentation, diagnosis remains a challenge and coeliac disease is heavily underdiagnosed. The diagnosis of coeliac disease is achieved by combining coeliac disease serology and small intestinal mucosal histology during a gluten-containing diet. Currently, the only effective treatment for coeliac disease is a lifelong strict gluten-free diet; however, the diet is restrictive and gluten is difficult to avoid. Optimizing diagnosis and care in coeliac disease requires continuous research and education of both patients and health-care professionals.

Original languageEnglish (US)
Article number3
JournalNature Reviews Disease Primers
Volume5
Issue number1
DOIs
StatePublished - Dec 1 2019

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Celiac Disease
Glutens
Diet
Gluten-Free Diet
Adaptive Immunity
Patient Education
Serology
Hordeum
Innate Immunity
Triticum
Signs and Symptoms
Histology
Patient Care
Eating
Delivery of Health Care
Food
Peptides
Antibodies
Research

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lindfors, K., Ciacci, C., Kurppa, K., Lundin, K. E. A., Makharia, G. K., Mearin, M. L., ... Kaukinen, K. (2019). Coeliac disease. Nature Reviews Disease Primers, 5(1), [3]. https://doi.org/10.1038/s41572-018-0054-z

Coeliac disease. / Lindfors, Katri; Ciacci, Carolina; Kurppa, Kalle; Lundin, Knut E.A.; Makharia, Govind K.; Mearin, M. Luisa; Murray, Joseph A; Verdu, Elena F.; Kaukinen, Katri.

In: Nature Reviews Disease Primers, Vol. 5, No. 1, 3, 01.12.2019.

Research output: Contribution to journalReview article

Lindfors, K, Ciacci, C, Kurppa, K, Lundin, KEA, Makharia, GK, Mearin, ML, Murray, JA, Verdu, EF & Kaukinen, K 2019, 'Coeliac disease', Nature Reviews Disease Primers, vol. 5, no. 1, 3. https://doi.org/10.1038/s41572-018-0054-z
Lindfors K, Ciacci C, Kurppa K, Lundin KEA, Makharia GK, Mearin ML et al. Coeliac disease. Nature Reviews Disease Primers. 2019 Dec 1;5(1). 3. https://doi.org/10.1038/s41572-018-0054-z
Lindfors, Katri ; Ciacci, Carolina ; Kurppa, Kalle ; Lundin, Knut E.A. ; Makharia, Govind K. ; Mearin, M. Luisa ; Murray, Joseph A ; Verdu, Elena F. ; Kaukinen, Katri. / Coeliac disease. In: Nature Reviews Disease Primers. 2019 ; Vol. 5, No. 1.
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