Coccidioidomycosis in patients with hematologic malignancies

Janis E. Blair, Jerry D. Smilack, Sean M. Caples

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Background: An endemic fungal infection of the desert southwestern United States, coccidioidomycosis is generally a self-limited illness in healthy persons. Immunosuppressed persons who contract coccidioidomycosis, however, are at increased risk for disseminated infection. Methods: We conducted a retrospective review of patients with coccidioidomycosis and hematologic malignancy or bone marrow disease. Results: Fifty-five patients were identified. The most common underlying malignancies were non-Hodgkin lymphoma and chronic lymphocytic leukemia. Extrathoracic (or disseminated) infection was observed in 12 patients (22%). Fifteen patients (27%) died with active coccidioidomycosis. Treatment of the hematologic disease with corticosteroids or antineoplastic chemotherapy increased the risk of death. Conclusion: To date, this is the largest case series of patients with hematologic malignancy and coccidioidomycosis. In persons with hematologic malignancy, coccidioidomycosis can be a severe illness with a high risk for disseminated infection and death.

Original languageEnglish (US)
Pages (from-to)113-117
Number of pages5
JournalArchives of Internal Medicine
Volume165
Issue number1
DOIs
StatePublished - Jan 10 2005

Fingerprint

Coccidioidomycosis
Hematologic Neoplasms
Infection
Bone Marrow Diseases
Southwestern United States
Mycoses
Hematologic Diseases
B-Cell Chronic Lymphocytic Leukemia
Antineoplastic Agents
Non-Hodgkin's Lymphoma
Adrenal Cortex Hormones
Drug Therapy
Neoplasms

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Coccidioidomycosis in patients with hematologic malignancies. / Blair, Janis E.; Smilack, Jerry D.; Caples, Sean M.

In: Archives of Internal Medicine, Vol. 165, No. 1, 10.01.2005, p. 113-117.

Research output: Contribution to journalArticle

Blair, Janis E. ; Smilack, Jerry D. ; Caples, Sean M. / Coccidioidomycosis in patients with hematologic malignancies. In: Archives of Internal Medicine. 2005 ; Vol. 165, No. 1. pp. 113-117.
@article{eb83a71f959d429993be4f420f950065,
title = "Coccidioidomycosis in patients with hematologic malignancies",
abstract = "Background: An endemic fungal infection of the desert southwestern United States, coccidioidomycosis is generally a self-limited illness in healthy persons. Immunosuppressed persons who contract coccidioidomycosis, however, are at increased risk for disseminated infection. Methods: We conducted a retrospective review of patients with coccidioidomycosis and hematologic malignancy or bone marrow disease. Results: Fifty-five patients were identified. The most common underlying malignancies were non-Hodgkin lymphoma and chronic lymphocytic leukemia. Extrathoracic (or disseminated) infection was observed in 12 patients (22{\%}). Fifteen patients (27{\%}) died with active coccidioidomycosis. Treatment of the hematologic disease with corticosteroids or antineoplastic chemotherapy increased the risk of death. Conclusion: To date, this is the largest case series of patients with hematologic malignancy and coccidioidomycosis. In persons with hematologic malignancy, coccidioidomycosis can be a severe illness with a high risk for disseminated infection and death.",
author = "Blair, {Janis E.} and Smilack, {Jerry D.} and Caples, {Sean M.}",
year = "2005",
month = "1",
day = "10",
doi = "10.1001/archinte.165.1.113",
language = "English (US)",
volume = "165",
pages = "113--117",
journal = "JAMA Internal Medicine",
issn = "2168-6106",
publisher = "American Medical Association",
number = "1",

}

TY - JOUR

T1 - Coccidioidomycosis in patients with hematologic malignancies

AU - Blair, Janis E.

AU - Smilack, Jerry D.

AU - Caples, Sean M.

PY - 2005/1/10

Y1 - 2005/1/10

N2 - Background: An endemic fungal infection of the desert southwestern United States, coccidioidomycosis is generally a self-limited illness in healthy persons. Immunosuppressed persons who contract coccidioidomycosis, however, are at increased risk for disseminated infection. Methods: We conducted a retrospective review of patients with coccidioidomycosis and hematologic malignancy or bone marrow disease. Results: Fifty-five patients were identified. The most common underlying malignancies were non-Hodgkin lymphoma and chronic lymphocytic leukemia. Extrathoracic (or disseminated) infection was observed in 12 patients (22%). Fifteen patients (27%) died with active coccidioidomycosis. Treatment of the hematologic disease with corticosteroids or antineoplastic chemotherapy increased the risk of death. Conclusion: To date, this is the largest case series of patients with hematologic malignancy and coccidioidomycosis. In persons with hematologic malignancy, coccidioidomycosis can be a severe illness with a high risk for disseminated infection and death.

AB - Background: An endemic fungal infection of the desert southwestern United States, coccidioidomycosis is generally a self-limited illness in healthy persons. Immunosuppressed persons who contract coccidioidomycosis, however, are at increased risk for disseminated infection. Methods: We conducted a retrospective review of patients with coccidioidomycosis and hematologic malignancy or bone marrow disease. Results: Fifty-five patients were identified. The most common underlying malignancies were non-Hodgkin lymphoma and chronic lymphocytic leukemia. Extrathoracic (or disseminated) infection was observed in 12 patients (22%). Fifteen patients (27%) died with active coccidioidomycosis. Treatment of the hematologic disease with corticosteroids or antineoplastic chemotherapy increased the risk of death. Conclusion: To date, this is the largest case series of patients with hematologic malignancy and coccidioidomycosis. In persons with hematologic malignancy, coccidioidomycosis can be a severe illness with a high risk for disseminated infection and death.

UR - http://www.scopus.com/inward/record.url?scp=11844262594&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=11844262594&partnerID=8YFLogxK

U2 - 10.1001/archinte.165.1.113

DO - 10.1001/archinte.165.1.113

M3 - Article

C2 - 15642886

AN - SCOPUS:11844262594

VL - 165

SP - 113

EP - 117

JO - JAMA Internal Medicine

JF - JAMA Internal Medicine

SN - 2168-6106

IS - 1

ER -